DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ih and kcnh3

DIOPT Version :9

Sequence 1:	NP_001033948.1	Gene:	Ih / 36589	FlyBaseID:	FBgn0263397	Length:	1327	Species:	Drosophila melanogaster
Sequence 2:	XP_001919436.3	Gene:	kcnh3 / 100006614	ZFINID:	ZDB-GENE-070912-23	Length:	1192	Species:	Danio rerio

Alignment Length:	732	Identity:	157/732 - (21%)
Similarity:	279/732 - (38%)	Gaps:	206/732 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   708 QLQSWFQPTDN---RLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLLVANLI 769
            ||....|..|.   ::...:||.:..:.:.::.......:::....:|:..||..:||......:
Zfish   178 QLSGHLQKQDKSKLKINNNMFGEKPPIPEYKVAAIQKSRFILLHYGTFKAGWDWLILLATFYVAV 242

  Fly   770 ILPVAISFF----NDDLSTRW---IAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAK 827
            .:|..:.|.    .|:.||..   ...:.|.:.:|::|||:||||..:  ..:.||:.|.:.|..
Zfish   243 TVPYNVCFTVVGGRDEASTPRSPPSVSDILVEILFMLDIVLNFRTTFV--STSGQVVYDARSICV 305

  Fly   828 HYLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQI-LHAGRALRILRLAKLLSLVRLLRLS 891
            ||:.||.|:|||:::|.|.::              :|.: ::.|        ..||..||||||.
Zfish   306 HYVTTWLFVDLIAALPFDLLY--------------AFNVSVYFG--------VHLLKTVRLLRLL 348

  Fly   892 RLVRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLL 956
            ||            ||.|::.|                         ..::|.:.:  |:.|..|
Zfish   349 RL------------LQKLERYS-------------------------QYSAVVLTL--LMSMFAL 374

  Fly   957 IGHWSGCL--------------------------------QFLVPMLQGFP-------------- 975
            :.||..|:                                .||.|:....|
Zfish   375 LAHWMACVWYIIGRSEIENNSPGSWDIGWLHELGKRLGTPYFLSPLASLIPDSLRPTILDGLVVN 439

  Fly   976 SNSWVSINEL-QESYW-------------------------------LEQYSWALFKAMSHMLCI 1008
            |:.|...:.: .|..|                               ...|..:|:.|:|.:..:
Zfish   440 SSQWNGSDLVAHEPVWNSSQLNSTGTAPAAPSNAGQTGAVLGGGPSIRSSYVTSLYFALSSLTSV 504

  Fly  1009 GYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKVKQVEEYMAYRKLP 1073
            |:|.....:.::...::.:|:.||..:|...|:.|.:||.:.|.|..|..:.|.:::::...:||
Zfish   505 GFGNVSANTDSEKIFSICTMLIGALMHAAVFGNVTAIIQRMYSRRSLYHTRTKDLKDFIRVHRLP 569

  Fly  1074 RDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVV 1137
            :.:.||:.|.|:..:. ....|...:|.:..::||.|:..:..:.|: .:|.|.:|....:..:.
Zfish   570 KALAQRMLECFQTTWSVNNGIDVSELLKDFPDELRADIAMHLNKELL-QLPLFESASRGCLRSLS 633

  Fly  1138 TKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYFG------EICLLTN 1196
            ..:|.....||:.:|::|.....:||:..|.::::..| .|...|..|...|      |..:.||
Zfish   634 LIIKTSFCAPGEFLIRQGDALQAIYFVCSGSMEVLKDN-TVLAILGKGDLIGSDSLTKEQVIKTN 697

  Fly  1197 ARRVASVRAETYCNLFSLSVDHFNCVLDQYPLMRKTMETVAAERLNKIGKNPNIMHQKDEQLSNP 1261
                |:|:|.|||:|..:|:.....||..||           |...|...  .|.|.....|...
Zfish   698 ----ANVKALTYCDLQYISLKGLREVLRLYP-----------EYAQKFVS--EIQHDLTYNLREG 745

  Fly  1262 -------ESNTITAVVNALAAEADDCKDDDMDLKENLLHGSESS-------IAEPVQTIREGL-- 1310
                   |||  ..:|..|.|..:|.::|:   ::|.:..:..|       ::.|   :|..|
Zfish   746 SGADLDWESN--GGLVKKLPAIREDEENDE---EQNSVSRAPRSPLRLTRALSSP---LRSPLLP 802

  Fly  1311 PRPRSGEFRALFEGNTP 1327
            |||    |||..|...|
Zfish   803 PRP----FRAPSESMRP 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:285597	5/44 (11%)
		Ion_trans	771..1054	CDD:278921	74/368 (20%)
		Crp	1118..>1241	CDD:223736	33/128 (26%)
		CAP_ED	1124..1233	CDD:237999	30/114 (26%)
kcnh3	XP_001919436.3	PAS	42..133	CDD:238075
		PAS_3	42..130	CDD:285623
		PLN03192	180..>684	CDD:215625	113/568 (20%)
		Ion_trans_2	<489..544	CDD:285168	13/54 (24%)
		CAP_ED	620..731	CDD:237999	32/126 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910