Protein Alignment Ih and kcnh8

DIOPT Version :10

• Sequence 1: NP_001033948.1
• Gene: Ih / 36589
• FlyBaseID: FBgn0263397
• Length: 1327
• Species: Drosophila melanogaster
• Sequence 2: XP_073787754.1
• Gene: kcnh8 / 100002967
• ZFINID: ZDB-GENE-060503-204
• Length: 1021
• Species: Danio rerio
• Alignment Length: 651
• Identity: 141/651 - (21%)
• Similarity: 265/651 - (40%)
• Gaps: 146/651 - (22%)

  Fly   700 VSANFLKSQLQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSSFRFYWDLCMLLLL 764
            :|.:....|.||..     :|...:||...||.:.::.......:::...|:|:..||..:||..
Zfish   174 ISGHLHNRQKQSKI-----KLNKNVFGDPPALPEYKVADAKKSKFILLHFSTFKAGWDWLILLAT 233

  Fly   765 VANLIILPVAISFFND-DLSTRWIAFNCLSDTIFLIDIVVNFRTGIMQQDNAEQVILDPKLIAKH 828
            ....:.:|..:.|..| ||:......:...:.:|:||||.:|||..:.:..  |||.|.:.|..|
Zfish   234 FYVAVTVPYNVCFIGDQDLTRSTTVTDIAVEILFIIDIVFSFRTTYVSKSG--QVIFDARQICIH 296

  Fly   829 YLRTWFFLDLISSIPLDYIFLIFNQIMKLQDFSDSFQILHAGRALRILRLAKLLSLVRLLRLSRL 893
            |:.|||.:||::::|.|.::              :|::       .::.:..||..||||||.||
Zfish   297 YMTTWFIIDLVAALPFDLLY--------------AFKV-------SVVSVVHLLKTVRLLRLLRL 340

  Fly   894 VRYVSQWEEVYILQNLQKKSADRRGRMNRKDKDGLTKSNLILKFLNMASVFMRIFNLICMMLLIG 958
            ::.:.::.:                           .|.::|..            |:.|..|:.
Zfish   341 LQKMDRYSQ---------------------------HSTVVLTL------------LMSMFALLA 366

  Fly   959 HWSGCLQFLVPMLQGFPSN--SWVSINELQESYWLEQ--------------------------YS 995
            ||..|:.:::...: ..||  :|       :..||.:                          |.
Zfish   367 HWMACIWYIIGKKE-VESNADTW-------DIGWLHELGKRLESPYEGVANRTLSSGPSLRSIYI 423

  Fly   996 WALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKV 1060
            .||:..:|.:..:|:|.....:..:...::.:|:.||..:||..|:.|.:||.:.|....|..:.
Zfish   424 AALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSSYHTRT 488

  Fly  1061 KQVEEYMAYRKLPRDMRQRITEYFEHRYQ-GKFFDEELILGELSEKLREDV-INYNCRSLVASVP 1123
            |.:::::....||:.::||:.|||:..:. ....|...:|.:..::||.|: ::.|...|..||
Zfish   489 KDLKDFIRVHHLPQSLKQRMLEYFQTTWSVNNGIDSNELLRDFPDELRSDIAMHLNKEILELSV- 552

  Fly  1124 FFANADSNFVSDVVTKLKYEVFQPGDIIIKEGTIGTKMYFIQEGVVDIVMANGEVATSLSDGSYF 1188
             |::.....:..:...:|.....||:.::::|.....::|:..|.::::..| .|...|..|...
Zfish   553 -FSSLSRGCLRSLSLHIKTSFCAPGEYLLRQGDALQALFFVCSGSMEVLKDN-MVLAILGKGDLI 615

  Fly  1189 ------GEICLLTNARRVASVRAETYCNLFSLSVDHFNCVLDQYP----------------LMRK 1231
                  |:..:.||    |.|:|.|||:|..:::.....|||.||                .:|:
Zfish   616 GANMSVGDRVIKTN----ADVKALTYCDLQCINLRGLYEVLDLYPEYSHRFVQDITHDLTYNLRE 676

  Fly  1232 TMETVAAERLNKIGKNPNIMHQKDEQLSNPESNTITAVVNALAA---EADDCKDDDMDLKENLLH 1293
            ..|:....|::.        ...|.|:....:.........:|.   |.||..|||.|.:...|.
Zfish   677 GQESHVISRMSS--------KSMDTQMEGRGNGDAIQCYPPIAEHHNEEDDDDDDDEDDQIQYLS 733

  Fly  1294 G 1294
            |
Zfish   734 G 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ih	NP_001033948.1	Ion_trans_N	709..751	CDD:400630	7/41 (17%)
		PLN03192	741..>1214	CDD:215625	112/509 (22%)
kcnh8	XP_073787754.1	None