Protein Alignment conv and LRRTM4

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_001317299.1
• Gene: LRRTM4 / 80059
• HGNCID: 19411
• Length: 591
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 110/527 - (20%)
• Similarity: 205/527 - (38%)
• Gaps: 174/527 - (33%)

  Fly   150 KELVIDGHAFQQLPKDLFAGQEIANSLGIIRVTNGNLSDLPIETFQPLRKLKTLDLHGNQLENLK 214
            |.:..:.|||..:|:::..|.:                              .|.|..|.::.||
Human    44 KIVYCESHAFADIPENISGGSQ------------------------------GLSLRFNSIQKLK 78

  Fly   215 RNQFKNLRELEVLDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSH 279
            .|||                        |.|.:|.|                        |:|.|
Human    79 SNQF------------------------AGLNQLIW------------------------LYLDH 95

  Fly   280 NQIARLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYV 344
            |.|:.:|.::|:|:|.|:.|.||.|.:|.:...||..:..:..:||:.|:|:.::.:.|
Human    96 NYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQF------ 154

  Fly   345 ELLDLAENNITKIEKNSFKDIYQAIINVSHNALELIETAAFENCVNITVLDLSHNRLANFSRRSF 409
                   ..:.|:          .|:::..|:|:.:....|::|.|:..|||.:|||.:.||.:|
Human   155 -------KGLRKL----------IILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAF 202

  Fly   410 DETTFATYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNSITEIPKNCFPKLYELHTIDVSHNNIS 474
                                    ..:..||.|:..:|..::|....||:|:.|.:|.:..|.|.
Human   203 ------------------------AGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIR 243

  Fly   475 SIFNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLY 539
            ||..|:..|..||.::|||.|.::.|:..||..||.|.:::|..|:|.::.:.::....||..:.
Human   244 SISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISIT 308

  Fly   540 LNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVV 604
            |:.|    :::...|:..|::            | :.|               ..|...:.::..
Human   309 LSGN----MWECSRSICPLFY------------W-LKN---------------FKGNKESTMICA 341

  Fly   605 QRLKLQNNGISQPPKDAVA---VMSTLQYLHLENNNIT--TLERSAFGKLPVLFELNLYGNQVKD 664
            ....:|...:|    |||.   :.|.:|.::.|.:::.  |.::......|.:|:        .|
Human   342 GPKHIQGEKVS----DAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRPTIFK--------PD 394

  Fly   665 ISKRAFE 671
            :::..||
Human   395 VTQSTFE 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380	6/24 (25%)
		leucine-rich repeat	176..199	CDD:275380	0/22 (0%)
		PPP1R42	191..359	CDD:455733	35/167 (21%)
		LRR_8	198..258	CDD:404697	12/59 (20%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..271	CDD:275380	4/46 (9%)
		leucine-rich repeat	272..295	CDD:275380	8/22 (36%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		leucine-rich repeat	322..343	CDD:275380	5/20 (25%)
		leucine-rich repeat	344..367	CDD:275380	1/22 (5%)
		LRR	346..718	CDD:443914	70/331 (21%)
		leucine-rich repeat	371..390	CDD:275380	4/18 (22%)
		leucine-rich repeat	391..414	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..438	CDD:275380	0/21 (0%)
		leucine-rich repeat	439..462	CDD:275380	8/22 (36%)
		leucine-rich repeat	463..486	CDD:275380	8/22 (36%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		leucine-rich repeat	535..554	CDD:275380	3/18 (17%)
		leucine-rich repeat	555..578	CDD:275380	2/22 (9%)
		leucine-rich repeat	579..603	CDD:275380	1/23 (4%)
		leucine-rich repeat	604..627	CDD:275380	5/25 (20%)
		leucine-rich repeat	628..649	CDD:275380	3/22 (14%)
		PPP1R42	631..849	CDD:455733	7/43 (16%)
		leucine-rich repeat	652..672	CDD:275380	4/20 (20%)
		leucine-rich repeat	700..726	CDD:275380
		leucine-rich repeat	727..745	CDD:275380
		leucine-rich repeat	779..802	CDD:275380
		leucine-rich repeat	829..852	CDD:275380
LRRTM4	NP_001317299.1	leucine-rich repeat	44..62	CDD:275380	5/17 (29%)
		leucine-rich repeat	65..87	CDD:275380	10/75 (13%)
		LRR	67..>312	CDD:443914	84/339 (25%)
		leucine-rich repeat	88..111	CDD:275380	10/46 (22%)
		leucine-rich repeat	112..135	CDD:275380	8/22 (36%)
		leucine-rich repeat	136..159	CDD:275380	5/35 (14%)
		leucine-rich repeat	160..183	CDD:275380	5/32 (16%)
		leucine-rich repeat	184..207	CDD:275380	9/46 (20%)
		leucine-rich repeat	208..231	CDD:275380	8/22 (36%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	256..279	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..316	CDD:275378	3/15 (20%)