DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and igfals

DIOPT Version :9

Sequence 1:NP_001286416.1 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:XP_003198203.1 Gene:igfals / 570758 ZFINID:ZDB-GENE-061009-25 Length:614 Species:Danio rerio


Alignment Length:753 Identity:182/753 - (24%)
Similarity:290/753 - (38%) Gaps:262/753 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 TKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIG 310
            |:..|  :..|..|.|..|.|.:.:.|:.|:|..:.:..|||::|||:..|..|.|..|.|..:.
Zfish    84 TRSLW--LDGNLFSNLPAGAFEKLTNLEFLNLQSSLLVSLDAHAFRGLNSLAHLHLERNNLRSLS 146

  Fly   311 RGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHN 375
            ...|...:.:.|:.|..|::.:|:.::|..|:::.||:|..|.::.:.:..|:|:        |.
Zfish   147 GLVFQGTSNLATLSLNNNQMFRIDDRLFAGMSHMWLLNLGWNLLSVLPETGFQDL--------HG 203

  Fly   376 ALELIETAAFENCVNITVLDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLK 440
            ..|||               |:.||||              |.|                     
Zfish   204 LRELI---------------LAGNRLA--------------YLQ--------------------- 218

  Fly   441 VLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTF 505
                             |:|                    ||.|..|:.:||:.|.::.||::.|
Zfish   219 -----------------PQL--------------------FQGLNELKELDLTGNYLKVIKANVF 246

  Fly   506 GTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPS 570
            ..||.|.::.|..|::|:|...:...:.|||                                  
Zfish   247 LKLPKLQKLYLGQNQIVTVAPRAFVGMKSLR---------------------------------- 277

  Fly   571 GTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLEN 635
                      :||||.|:| ..|:.|:|.||                        .:|..|.|.|
Zfish   278 ----------WLDLSRNRL-TVLHDETFIGL------------------------QSLHVLRLSN 307

  Fly   636 NNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQ------------- 687
            |:|.:|....|..|..|.||.||.||::.:..|.||||..|..|||.:|.:|             
Zfish   308 NSINSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHL 372

  Fly   688 -----------TLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISFVT 741
                       :|.:.:|.||..|.::.|..:.|||:.:::   ...|..|..|.|.||.||.|.
Zfish   373 AVMKLTGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQS---FSGLTGLRRLFLQHNNISLVE 434

  Fly   742 KKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSL 806
            :::|...|    .|:.|:|.:|.:..:|.:..:|.|                        :|..|
Zfish   435 RQSFVELQ----RLQQLDLRFNKLTTITSNTFYGLK------------------------NLDYL 471

  Fly   807 DMSYNELSNLKSEEHIFDLP-QNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLEDVPASI 870
            .:|.|.|.||.:|..   || |:|||||||.||:..:..|.:..:..|:|::|.:|.|.::|.||
Zfish   472 LLSGNLLHNLPAEAL---LPLQHLSWLDLSGNKLELILNATIYMLPRLRYLNLKDNILVNLPVSI 533

  Fly   871 VGSMRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLH 935
            ..|:   .|:.|:||...|.|:|:|.:.|:||:                    .|::.|..|.|.
Zfish   534 PESL---DQLWLSGNNWKCDCSAKPFRDFILQK--------------------PQVVPLQVEMLG 575

  Fly   936 CAEDEQEMY--------------KGIDYEQLTDVRFRE 959
            ..|:...:.              .|:|...:....||:
Zfish   576 EGEEPHTLITVYNNVTCASPSSASGLDLRNIAAEHFRD 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_001286416.1 leucine-rich repeat 125..148 CDD:275380
leucine-rich repeat 150..175 CDD:275380
leucine-rich repeat 176..199 CDD:275380
LRR_8 198..258 CDD:290566 3/11 (27%)
leucine-rich repeat 200..223 CDD:275380
LRR_RI 201..545 CDD:238064 67/298 (22%)
leucine-rich repeat 224..271 CDD:275380 7/24 (29%)
LRR_8 245..306 CDD:290566 20/59 (34%)
leucine-rich repeat 272..295 CDD:275380 9/22 (41%)
LRR_8 296..354 CDD:290566 16/57 (28%)
leucine-rich repeat 296..319 CDD:275380 6/22 (27%)
LRR_8 322..401 CDD:290566 18/78 (23%)
leucine-rich repeat 322..343 CDD:275380 6/20 (30%)
leucine-rich repeat 344..367 CDD:275380 6/22 (27%)
leucine-rich repeat 371..390 CDD:275380 4/18 (22%)
leucine-rich repeat 391..414 CDD:275380 5/22 (23%)
leucine-rich repeat 416..438 CDD:275380 2/21 (10%)
LRR_8 437..495 CDD:290566 8/57 (14%)
leucine-rich repeat 439..462 CDD:275380 2/22 (9%)
leucine-rich repeat 463..486 CDD:275380 3/22 (14%)
LRR_RI 486..738 CDD:238064 70/275 (25%)
LRR_8 486..545 CDD:290566 17/58 (29%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
leucine-rich repeat 535..554 CDD:275380 2/18 (11%)
LRR_8 554..614 CDD:290566 11/59 (19%)
leucine-rich repeat 555..578 CDD:275380 0/22 (0%)
leucine-rich repeat 579..603 CDD:275380 11/23 (48%)
leucine-rich repeat 604..627 CDD:275380 0/22 (0%)
LRR_8 626..710 CDD:290566 33/107 (31%)
leucine-rich repeat 628..649 CDD:275380 8/20 (40%)
leucine-rich repeat 652..672 CDD:275380 9/19 (47%)
LRR_8 698..765 CDD:290566 20/66 (30%)
leucine-rich repeat 700..726 CDD:275380 6/25 (24%)
leucine-rich repeat 727..745 CDD:275380 8/17 (47%)
LRR_8 777..839 CDD:290566 20/62 (32%)
leucine-rich repeat 779..802 CDD:275380 0/22 (0%)
leucine-rich repeat 829..852 CDD:275380 10/22 (45%)
igfalsXP_003198203.1 LRRNT 48..81 CDD:279764
leucine-rich repeat 65..83 CDD:275380
leucine-rich repeat 84..107 CDD:275380 7/24 (29%)
LRR_8 85..142 CDD:290566 19/58 (33%)
leucine-rich repeat 108..131 CDD:275380 9/22 (41%)
LRR_8 131..214 CDD:290566 24/105 (23%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
leucine-rich repeat 156..203 CDD:275380 12/54 (22%)
leucine-rich repeat 204..227 CDD:275380 15/109 (14%)
LRR_RI <219..456 CDD:238064 84/332 (25%)
LRR_8 227..286 CDD:290566 22/102 (22%)
leucine-rich repeat 228..251 CDD:275380 8/22 (36%)
leucine-rich repeat 252..275 CDD:275380 5/22 (23%)
LRR_8 274..334 CDD:290566 29/128 (23%)
leucine-rich repeat 276..299 CDD:275380 13/91 (14%)
leucine-rich repeat 300..323 CDD:275380 9/22 (41%)
leucine-rich repeat 324..347 CDD:275380 12/22 (55%)
leucine-rich repeat 348..369 CDD:275380 6/20 (30%)
LRR_8 371..430 CDD:290566 15/61 (25%)
leucine-rich repeat 396..419 CDD:275380 6/25 (24%)
LRR_8 418..478 CDD:290566 21/87 (24%)
leucine-rich repeat 420..443 CDD:275380 10/26 (38%)
leucine-rich repeat 444..467 CDD:275380 7/46 (15%)
LRR_8 466..524 CDD:290566 25/84 (30%)
leucine-rich repeat 468..486 CDD:275380 8/17 (47%)
leucine-rich repeat 492..515 CDD:275380 10/22 (45%)
leucine-rich repeat 516..540 CDD:275380 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4879
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.940

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