DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Tlr5

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	XP_017177186.1	Gene:	Tlr5 / 53791	MGIID:	1858171	Length:	873	Species:	Mus musculus

Alignment Length:	795	Identity:	193/795 - (24%)
Similarity:	307/795 - (38%)	Gaps:	214/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 NLAQIP-IQNMTGLKVLNASYNSITEIPKNCFPKLYELHTIDV--SHNNISSIFNGVFQTLFSLR 488
            ||.||| |.|.|..::| .|:|.|:.:....||.|..|..:::  .:.|: :|..|.|:.|.:||
Mouse    51 NLTQIPWILNTTTERLL-LSFNYISMVVATSFPLLERLQLLELGTQYANL-TIGPGAFRNLPNLR 113

  Fly   489 SIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVV--RGSLAKLTSLRQLYLNNNQLEKL--- 548
            .:||..:.:..:....|..||.|||:.|....|.|.|  .|....|.||.:|.|:.||:..|
Mouse   114 ILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQIHSLRLH 178

  Fly   549 --FQLPISLNELYFSHNRLTNI--------------------------PSGTWPVMNS------L 579
              |:...||:::.|:.|::..|                          .|..|....:      |
Mouse   179 SSFRELNSLSDVNFAFNQIFTICEDELEPLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRL 243

  Fly   580 IYLDLSHN--------QLGDTLNGESFTGLLVVQRLK-----LQNNGISQPPKDAVAVM--STLQ 629
            ..||||.|        ...:.:.|...:.|::...:.     .||  |..|.:...|.:  |::.
Mouse   244 ETLDLSENGWTVDITRNFSNIIQGSQISSLILKHHIMGPGFGFQN--IRDPDQSTFASLARSSVL 306

  Fly   630 YLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIF 694
            .|.|.:..|.:|....||.|..|..|||..|::..|.:.||.||..|..||||.|.:..|.|..|
Mouse   307 QLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNF 371

  Fly   695 VGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLET------------------------------ 729
            .|||.:..:||..|.:..:.::|..:|..|.:|:.
Mouse   372 YGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPHI 436

  Fly   730 ------LDLSHNRISFVTKKTF----PSHQYIPYN------------------LRNLNLSYNLMP 766
                  |:||.||:..::...|    |..|::..|                  |..|.|:.|::.
Mouse   437 HFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQLFLTENMLQ 501

  Fly   767 I-----LTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLP 826
            :     |.:|:..|..:|..|.:|:|.:|.|..|:.::..:|:.|.:|.|:|:.|...    .||
Mouse   502 LAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSPG----SLP 562

  Fly   827 QNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLE-DVPASIVGSMRNGSQVLLAGNPLHCG 890
            .||..||:|.|:::. |...|  ..||:.:|:|:|... :...|...|..|.:.|.|.|:|
Mouse   563 ANLEILDISRNQLFS-PDPAL--FSSLRVLDITHNEFVCNCELSTFISWLNQTNVTLFGSP---- 620

  Fly   891 CNARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLHCAEDEQEMYKGIDYE----- 950
                                ..:||..|..:....|.::..|  .|  ||:|..:.:.:.
Mouse   621 --------------------ADVYCMYPNSLLGGSLYNISTE--DC--DEEEAMRSLKFSLFILC 661

  Fly   951 ----------QLTDVRFREVKTNKAGMLTLCWYVSG---FSD--------VSDFHVYIRSSSND- 993
                      .|..::||       |:..||:....   |.|        ...:..|...||.|
Mouse   662 TVTLTLFLVITLVVIKFR-------GICFLCYKTIQKLVFKDKVWSLEPGAYRYDAYFCFSSKDF 719

  Fly   994 ------VLHQSDYAYNNRT-AQIPVEELSTL-GEEKLRGAE---------ICIVSRD--SDGNTR 1039
                  :|...|..|::|. .::..||...: ||..:...:         :|:|||.  .||...
Mouse   720 EWAQNALLKHLDAHYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCL 784

  Fly  1040 KWFS-GQCQQLPSLK 1053
            :.|. .|.:.|..||
Mouse   785 EAFRYAQSRSLSDLK 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	42/122 (34%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380
		leucine-rich repeat	416..438	CDD:275380	7/11 (64%)
		LRR_8	437..495	CDD:290566	18/59 (31%)
		leucine-rich repeat	439..462	CDD:275380	7/22 (32%)
		leucine-rich repeat	463..486	CDD:275380	6/24 (25%)
		LRR_RI	486..738	CDD:238064	86/341 (25%)
		LRR_8	486..545	CDD:290566	21/60 (35%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	9/24 (38%)
		leucine-rich repeat	535..554	CDD:275380	7/23 (30%)
		LRR_8	554..614	CDD:290566	17/104 (16%)
		leucine-rich repeat	555..578	CDD:275380	6/48 (13%)
		leucine-rich repeat	579..603	CDD:275380	8/31 (26%)
		leucine-rich repeat	604..627	CDD:275380	5/29 (17%)
		LRR_8	626..710	CDD:290566	33/83 (40%)
		leucine-rich repeat	628..649	CDD:275380	6/20 (30%)
		leucine-rich repeat	652..672	CDD:275380	8/19 (42%)
		LRR_8	698..765	CDD:290566	21/124 (17%)
		leucine-rich repeat	700..726	CDD:275380	6/25 (24%)
		leucine-rich repeat	727..745	CDD:275380	6/53 (11%)
		LRR_8	777..839	CDD:290566	21/61 (34%)
		leucine-rich repeat	779..802	CDD:275380	7/22 (32%)
		leucine-rich repeat	829..852	CDD:275380	7/22 (32%)
Tlr5	XP_017177186.1	leucine-rich repeat	63..93	CDD:275380	8/30 (27%)
		LRR_8	<101..146	CDD:338972	15/44 (34%)
		leucine-rich repeat	112..135	CDD:275380	6/22 (27%)
		leucine-rich repeat	136..161	CDD:275380	9/24 (38%)
		leucine-rich repeat	162..186	CDD:275380	7/23 (30%)
		leucine-rich repeat	187..242	CDD:275380	6/54 (11%)
		leucine-rich repeat	243..304	CDD:275380	13/62 (21%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		LRR_8	308..363	CDD:338972	23/54 (43%)
		leucine-rich repeat	329..352	CDD:275380	10/22 (45%)
		LRR_8	352..411	CDD:338972	19/58 (33%)
		leucine-rich repeat	353..376	CDD:275380	11/22 (50%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		PRK15370	<397..>597	CDD:185268	47/206 (23%)
		leucine-rich repeat	401..429	CDD:275380	2/27 (7%)
		leucine-rich repeat	430..464	CDD:275380	6/33 (18%)
		leucine-rich repeat	465..489	CDD:275380	2/23 (9%)
		leucine-rich repeat	490..518	CDD:275380	7/27 (26%)
		leucine-rich repeat	519..542	CDD:275380	7/22 (32%)
		leucine-rich repeat	543..561	CDD:275380	6/21 (29%)
		leucine-rich repeat	565..585	CDD:275380	7/22 (32%)
		PCC	569..>647	CDD:188093	24/108 (22%)
		TIR	708..858	CDD:366714	23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910