DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and TLR8

DIOPT Version :9

Sequence 1:NP_001286416.1 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1029 Identity:237/1029 - (23%)
Similarity:403/1029 - (39%) Gaps:214/1029 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 GVNNTLEQLHLLRTNLSHVGLLGFGILGKAKELVIDGHAFQQLPKDLFAGQEIANSLGIIRVTNG 184
            |.....|.:.|..:.|:.:.||   |.|.. ||..:.:..:..|.|    ::..|...|...:|.
Human    14 GKETKKENMFLQSSMLTCIFLL---ISGSC-ELCAEENFSRSYPCD----EKKQNDSVIAECSNR 70

  Fly   185 NLSDLPIETFQPLRKLKT-LDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLEAQHIADLTKL 248
            .|.::|    |.:.|..| |||..|.:.::....|:.|:.|..::::||.    ..||     :.
Human    71 RLQEVP----QTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNP----NVQH-----QN 122

  Fly   249 GWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGM-RFLRRLFLSDNVLTDIGRG 312
            |...:..|.|: ::.|.|.....|:.|.|..||:.::.:    |: ..|..|.|..|.:.:|.:.
Human   123 GNPGIQSNGLN-ITDGAFLNLKNLRELLLEDNQLPQIPS----GLPESLTELSLIQNNIYNITKE 182

  Fly   313 TFGSIARIGTIDLARN-------RLKKIEFQMFTQMNYVELLDLAENNITKIE---KNSFKDIYQ 367
            ....:..:..:.||.|       ....||..:|..:..:|||.|:.|:::.:.   .:|.:.:: 
Human   183 GISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF- 246

  Fly   368 AIINVSHNALELIETAAFENCVNITVLDLSHN-----------------RLANFSRRSFDETTFA 415
                :|:..::.|....|:..:|:|:||||.|                 ...|..|.:|...|..
Human   247 ----LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQL 307

  Fly   416 TYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNSIT-EIPKNCF-PKLYELHTIDVSHNNISSIF- 477
            .|..||..:|..:.....:||..||||:..:|.:. ||....| ..|..|..:|:|.|.|...: 
Human   308 RYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYP 372

  Fly   478 -----NGVFQTLFSLRSIDLSHNSMREIKSSTFG---TLPTLLEMDLSHNELVSVVRGSLAKLTS 534
                 :..|..|.|||::.|.....:|::...|.   .||.|..::|..|.:..:........::
Human   373 QHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSN 437

  Fly   535 LRQLYLNNNQLEKL-------------FQ------------------------------------ 550
            |..:||:.|::..|             ||                                    
Human   438 LEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGK 502

  Fly   551 -LPISLNELYF-SHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNG 613
             |.:|||.::| ..|:..|:|        .:..|:||.|.....|:|..|:.:..|:.|.|.||.
Human   503 ALDLSLNSIFFIGPNQFENLP--------DIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 559

  Fly   614 ISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLT 678
            :......|:..:|.|:.|.|..|:      ..|....|...|....|            ...|..
Human   560 LDFDNASALTELSDLEVLDLSYNS------HYFRIAGVTHHLEFIQN------------FTNLKV 606

  Fly   679 LNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKL----DNKTNGVLDDLLSLETLDLSHNRISF 739
            ||||.|.|.||.:...:...||..|..|.|.|..|    ||:...:...|.:|..||||.||:..
Human   607 LNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKH 671

  Fly   740 VTKKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQ 804
            :..:.|.:   :|.:|..|:::.|::....:.:                        :..|..|:
Human   672 IPNEAFLN---LPASLTELHINDNMLKFFNWTL------------------------LQQFPRLE 709

  Fly   805 SLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLEDVPAS 869
            .||:..|:|  |...:.:.|...:|..|.||||:|.|||...|.:|.|||::||::|.|:.:..|
Human   710 LLDLRGNKL--LFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 772

  Fly   870 IVGSMRNG--SQVLLAGNPLHCGCNARPLKYFMLQQ-TIAGEDLKSIYCGTPALIKDKQLISLDD 931
            .:.:....  |.:.|.|||..|.|:....:.:|.:. .:....|..:.|.:|...:.|.::||  
Human   773 ALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL-- 835

  Fly   932 EYLHCAEDEQEMYKGIDYEQLTDV---RFREVKTNKAGMLTLC--------WYVSGFSDVSDFHV 985
            |...|..|            :|.|   .|....|....:..|.        |::.... ::....
Human   836 ELTTCVSD------------VTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVC-LAKVKG 887

  Fly   986 YIRSSSNDVLHQSDYAYNNRTAQIP---VEELS-TLGEEKLRGAEICIVSRDSD 1035
            |...|::...:.:..:|:.:.|.:.   :.||. .|.|.:.:...:|:..||.|
Human   888 YRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWD 941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_001286416.1 leucine-rich repeat 125..148 CDD:275380 6/22 (27%)
leucine-rich repeat 150..175 CDD:275380 4/24 (17%)
leucine-rich repeat 176..199 CDD:275380 5/22 (23%)
LRR_8 198..258 CDD:290566 15/60 (25%)
leucine-rich repeat 200..223 CDD:275380 7/23 (30%)
LRR_RI 201..545 CDD:238064 91/383 (24%)
leucine-rich repeat 224..271 CDD:275380 10/46 (22%)
LRR_8 245..306 CDD:290566 15/61 (25%)
leucine-rich repeat 272..295 CDD:275380 6/23 (26%)
LRR_8 296..354 CDD:290566 16/64 (25%)
leucine-rich repeat 296..319 CDD:275380 5/22 (23%)
LRR_8 322..401 CDD:290566 22/105 (21%)
leucine-rich repeat 322..343 CDD:275380 6/27 (22%)
leucine-rich repeat 344..367 CDD:275380 6/25 (24%)
leucine-rich repeat 371..390 CDD:275380 3/18 (17%)
leucine-rich repeat 391..414 CDD:275380 9/39 (23%)
leucine-rich repeat 416..438 CDD:275380 6/21 (29%)
LRR_8 437..495 CDD:290566 20/65 (31%)
leucine-rich repeat 439..462 CDD:275380 9/24 (38%)
leucine-rich repeat 463..486 CDD:275380 7/28 (25%)
LRR_RI 486..738 CDD:238064 74/309 (24%)
LRR_8 486..545 CDD:290566 15/61 (25%)
leucine-rich repeat 487..510 CDD:275380 6/25 (24%)
leucine-rich repeat 511..534 CDD:275380 3/22 (14%)
leucine-rich repeat 535..554 CDD:275380 8/68 (12%)
LRR_8 554..614 CDD:290566 19/60 (32%)
leucine-rich repeat 555..578 CDD:275380 6/23 (26%)
leucine-rich repeat 579..603 CDD:275380 7/23 (30%)
leucine-rich repeat 604..627 CDD:275380 6/22 (27%)
LRR_8 626..710 CDD:290566 23/83 (28%)
leucine-rich repeat 628..649 CDD:275380 5/20 (25%)
leucine-rich repeat 652..672 CDD:275380 2/19 (11%)
LRR_8 698..765 CDD:290566 22/70 (31%)
leucine-rich repeat 700..726 CDD:275380 9/29 (31%)
leucine-rich repeat 727..745 CDD:275380 7/17 (41%)
LRR_8 777..839 CDD:290566 14/61 (23%)
leucine-rich repeat 779..802 CDD:275380 1/22 (5%)
leucine-rich repeat 829..852 CDD:275380 12/22 (55%)
TLR8NP_057694.2 LRR_8 83..155 CDD:290566 21/81 (26%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
leucine-rich repeat 107..144 CDD:275380 10/46 (22%)
leucine-rich repeat 145..165 CDD:275380 6/23 (26%)
leucine-rich repeat 166..189 CDD:275380 5/22 (23%)
leucine-rich repeat 190..220 CDD:275380 6/29 (21%)
leucine-rich repeat 221..241 CDD:275380 5/19 (26%)
LRR_8 240..317 CDD:290566 18/81 (22%)
leucine-rich repeat 242..265 CDD:275380 3/27 (11%)
leucine-rich repeat 266..306 CDD:275380 9/39 (23%)
LRR_8 305..367 CDD:290566 20/61 (33%)
leucine-rich repeat 307..330 CDD:275380 6/22 (27%)
leucine-rich repeat 331..356 CDD:275380 9/24 (38%)
leucine-rich repeat 387..413 CDD:275380 6/25 (24%)
LRR_8 412..>449 CDD:290566 8/36 (22%)
leucine-rich repeat 414..437 CDD:275380 3/22 (14%)
LRR_8 502..560 CDD:290566 20/65 (31%)
LRR_RI <504..719 CDD:238064 67/269 (25%)
leucine-rich repeat 504..524 CDD:275380 8/27 (30%)
leucine-rich repeat 525..549 CDD:275380 7/23 (30%)
LRR_8 548..614 CDD:290566 21/83 (25%)
leucine-rich repeat 550..573 CDD:275380 6/22 (27%)
leucine-rich repeat 574..603 CDD:275380 8/46 (17%)
leucine-rich repeat 604..658 CDD:275380 19/53 (36%)
LRR_8 657..718 CDD:290566 17/87 (20%)
leucine-rich repeat 659..683 CDD:275380 9/26 (35%)
leucine-rich repeat 684..707 CDD:275380 4/46 (9%)
LRR_8 706..766 CDD:290566 25/61 (41%)
leucine-rich repeat 708..730 CDD:275380 7/23 (30%)
leucine-rich repeat 732..755 CDD:275380 12/22 (55%)
leucine-rich repeat 756..775 CDD:275380 7/18 (39%)
LRRCT 790..835 CDD:214507 9/44 (20%)
TIR 898..1040 CDD:214587 10/44 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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