DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and TLR7

DIOPT Version :9

Sequence 1:NP_001286416.1 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:963 Identity:230/963 - (23%)
Similarity:388/963 - (40%) Gaps:251/963 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   237 LEAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQ-IARLD--ANSFRGMRFLRR 298
            |...||.|::...:..:.|  |.|:.   |..|.|...|...:|. |.||.  ..||.|:.:|:.
Human    72 LTINHIPDISPASFHRLDH--LVEID---FRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKS 131

  Fly   299 LFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLDLAENNITKIEKNSFK 363
            |:|..|.|.:|.:|...|:.   .:.|..|.:..|..:..|::..:|:|.|.:|           
Human   132 LYLDGNQLLEIPQGLPPSLQ---LLSLEANNIFSIRKENLTELANIEILYLGQN----------- 182

  Fly   364 DIYQAIINVSHNALELIETAAFENCVNITVLDLSHNRLANFSRRSFDETTFATYFQL-SYNNL-- 425
            ..|:....||::    ||..||.|...:.||.|..|.:.     :......:|..:| .|||:  
Human   183 CYYRNPCYVSYS----IEKDAFLNLTKLKVLSLKDNNVT-----AVPTVLPSTLTELYLYNNMIA 238

  Fly   426 -------TNLAQIPIQNMTG--LKVLNASY-------NSITEIPKNCFPKLYELHTIDVSHNNIS 474
                   .||.|:.|.:::|  .:..||.:       ||..:||.|.|..|.||..:.:..|::.
Human   239 KIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303

  Fly   475 SIFNGVFQTLFSLRSIDLSHNSM-REIKSSTF-GTLPTLLEMDLSHNELVSVVRGS--------- 528
            .:....|:.:..|:.:|||.|.: :||..:.| ..||:|:::|||.|..:.|.|.|         
Human   304 HVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSS 368

  Fly   529 ------------------------LAKLTSLRQLYLNNN-----------QLEKLFQLPISLN-- 556
                                    |..|.:|..|.|..|           |.::|..:.:|:|  
Human   369 LKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKI 433

  Fly   557 -------ELYFSHNRLTNIPSGTWPVMNSLIY--------------------------------L 582
                   |:.|..|..|::.|....|:..|.|                                |
Human   434 SPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTL 498

  Fly   583 DLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDA-VAVMSTLQYLHLENNNITTLERSAF 646
            |||.|.: ..:....|..|..::.|.|..|.|||....: ...::.|:||...||.:..|..:||
Human   499 DLSKNSI-FFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAF 562

  Fly   647 GKLPVLFELNLYGNQVKDISKRAF----EGL------------LQLLTLN---LSSNGIQTLQND 692
            .:|..|        :|.|||..:.    ||:            ||.|.:|   :||:..:|::::
Human   563 EELHKL--------EVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESE 619

  Fly   693 IFVGLPSLRNLDLSFNSLTKL----DNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPY 753
                  |||.|:...|.|..|    ||:...:..:||.||.||:|.|.:||:....|..   :|.
Human   620 ------SLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDG---MPP 675

  Fly   754 NLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKS 818
            ||:||:|:.|.:.      :|..|||..|                  .:|::||:|:|:|:.:  
Human   676 NLKNLSLAKNGLK------SFSWKKLQCL------------------KNLETLDLSHNQLTTV-- 714

  Fly   819 EEHIFDLPQNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLEDV-----PASIVGSMRNGS 878
            .|.:.:..::|..|.|.:|:|..|....|.....|:|:||::|.::.:     |.:::.:::   
Human   715 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLK--- 776

  Fly   879 QVLLAGNPLHCGCNARPLKYFMLQQTIAGEDLKS-IYCGTPALIKDKQLISLDDEYLHCAEDEQE 942
            .:||..|...|.|:|....:::....:....|.: :.|..|...|.:.:||||   |:..|    
Human   777 MLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLD---LYTCE---- 834

  Fly   943 MYKGIDYEQLTDVRFREVKTNKAGMLTL-----------CWYVSGFSDVSDFHVYIRSSSNDVLH 996
                :|   ||::....:..:.:..|.:           .||:..|.. :....|.|..|.|..:
Human   835 ----LD---LTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCK-AKIKGYQRLISPDCCY 891

  Fly   997 QSDYAYNNR----TAQIPVEELSTLGEEKLRGAEICIVSRDSDGNTRKWFSGQ 1045
            .:...|:.:    |..:..|.::.|.:.:.:...:|:..||       |..||
Human   892 DAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERD-------WLPGQ 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_001286416.1 leucine-rich repeat 125..148 CDD:275380
leucine-rich repeat 150..175 CDD:275380
leucine-rich repeat 176..199 CDD:275380
LRR_8 198..258 CDD:290566 5/20 (25%)
leucine-rich repeat 200..223 CDD:275380
LRR_RI 201..545 CDD:238064 93/375 (25%)
leucine-rich repeat 224..271 CDD:275380 9/33 (27%)
LRR_8 245..306 CDD:290566 18/63 (29%)
leucine-rich repeat 272..295 CDD:275380 8/25 (32%)
LRR_8 296..354 CDD:290566 16/57 (28%)
leucine-rich repeat 296..319 CDD:275380 8/22 (36%)
LRR_8 322..401 CDD:290566 20/78 (26%)
leucine-rich repeat 322..343 CDD:275380 4/20 (20%)
leucine-rich repeat 344..367 CDD:275380 4/22 (18%)
leucine-rich repeat 371..390 CDD:275380 7/18 (39%)
leucine-rich repeat 391..414 CDD:275380 4/22 (18%)
leucine-rich repeat 416..438 CDD:275380 9/31 (29%)
LRR_8 437..495 CDD:290566 18/66 (27%)
leucine-rich repeat 439..462 CDD:275380 9/29 (31%)
leucine-rich repeat 463..486 CDD:275380 3/22 (14%)
LRR_RI 486..738 CDD:238064 89/362 (25%)
LRR_8 486..545 CDD:290566 24/104 (23%)
leucine-rich repeat 487..510 CDD:275380 9/24 (38%)
leucine-rich repeat 511..534 CDD:275380 10/55 (18%)
leucine-rich repeat 535..554 CDD:275380 6/29 (21%)
LRR_8 554..614 CDD:290566 20/100 (20%)
leucine-rich repeat 555..578 CDD:275380 7/31 (23%)
leucine-rich repeat 579..603 CDD:275380 9/55 (16%)
leucine-rich repeat 604..627 CDD:275380 6/23 (26%)
LRR_8 626..710 CDD:290566 28/102 (27%)
leucine-rich repeat 628..649 CDD:275380 8/20 (40%)
leucine-rich repeat 652..672 CDD:275380 5/23 (22%)
LRR_8 698..765 CDD:290566 27/70 (39%)
leucine-rich repeat 700..726 CDD:275380 9/29 (31%)
leucine-rich repeat 727..745 CDD:275380 8/17 (47%)
LRR_8 777..839 CDD:290566 15/61 (25%)
leucine-rich repeat 779..802 CDD:275380 2/22 (9%)
leucine-rich repeat 829..852 CDD:275380 7/22 (32%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 17/58 (29%)
LRR 21 619..644 9/30 (30%)
leucine-rich repeat 621..643 CDD:275380 8/21 (38%)
LRR 22 649..672 11/22 (50%)
leucine-rich repeat 652..676 CDD:275380 10/26 (38%)
LRR 23 674..697 11/28 (39%)
leucine-rich repeat 677..700 CDD:275380 10/46 (22%)
LRR 24 698..721 8/42 (19%)
leucine-rich repeat 701..724 CDD:275380 7/24 (29%)
LRR 25 723..745 7/21 (33%)
leucine-rich repeat 725..748 CDD:275380 7/22 (32%)
LRR 26 746..769 5/22 (23%)
leucine-rich repeat 749..767 CDD:275380 5/17 (29%)
PCC 753..>837 CDD:188093 21/100 (21%)
LRR 27 772..795 6/25 (24%)
TIR 890..>993 CDD:214587 10/55 (18%)
LRR 1 43..64
leucine-rich repeat 48..69 CDD:275380
LRR 2 65..87 4/14 (29%)
LRR_8 75..139 CDD:404697 21/68 (31%)
leucine-rich repeat 91..128 CDD:275380 13/39 (33%)
LRR 3 110..126 6/15 (40%)
LRR 4 127..149 7/21 (33%)
leucine-rich repeat 129..173 CDD:275380 12/46 (26%)
LRR 5 151..170 3/21 (14%)
LRR 6 171..195 7/38 (18%)
PLN00113 191..>711 CDD:215061 143/570 (25%)
LRR 7 203..226 4/27 (15%)
leucine-rich repeat 206..225 CDD:275380 4/23 (17%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
LRR 8 228..247 4/18 (22%)
LRR 9 248..275 6/26 (23%)
leucine-rich repeat 251..291 CDD:275380 11/39 (28%)
LRR 10 289..312 5/22 (23%)
leucine-rich repeat 292..315 CDD:275380 3/22 (14%)
LRR 11 314..337 8/22 (36%)
leucine-rich repeat 316..341 CDD:275380 9/24 (38%)
LRR 12 339..368 10/28 (36%)
leucine-rich repeat 342..371 CDD:275380 8/28 (29%)
LRR 13 369..392 0/22 (0%)
leucine-rich repeat 372..398 CDD:275380 2/25 (8%)
LRR 14 396..419 5/22 (23%)
leucine-rich repeat 399..422 CDD:275380 5/22 (23%)
LRR 15 421..443 4/21 (19%)
LRR <488..775 CDD:227223 88/330 (27%)
LRR 16 492..515 6/23 (26%)
leucine-rich repeat 496..518 CDD:275380 7/22 (32%)
LRR 17 516..540 7/23 (30%)
leucine-rich repeat 519..543 CDD:275380 6/23 (26%)
LRR 18 541..564 8/22 (36%)
leucine-rich repeat 544..567 CDD:275380 9/22 (41%)
LRR 19 566..588 7/29 (24%)
leucine-rich repeat 568..597 CDD:275380 7/36 (19%)
LRR 20 595..618 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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