DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Tlr11

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001138251.2	Gene:	Tlr11 / 498491	RGDID:	1564460	Length:	932	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	188/820 - (22%)
Similarity:	314/820 - (38%)	Gaps:	207/820 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 ELLDLAENNITKIEKNSFKDIYQA-----------IINVSHNALELIETAAFEN----CVNITVL 394
            |:|.| :..:..:..|:|...|..           |.:.:...|:.::...||:    |:::.:.
  Rat    89 EVLCL-QGMVPTLPANAFDGFYSLQLLRLQLGTTNITSRTFQGLDQLQYLFFEHHAPCCLSLFLP 152

  Fly   395 DLSHNRLANFSRRSFDETTFATYFQLSYNNL----TNLAQIPIQN--MTGLKVLNASYNSI---- 449
            ..|...|.:.|..||..      :.|:|::.    |.|..:.::|  :|.|:.|...:..:
  Rat   153 PDSLESLRSLSSLSFQG------YCLTYSHSIYLPTTLRHLTMRNSCLTKLQELQRLFPDLLLGA 211

  Fly   450 TEIPKNCFPKLYELHTIDVSHN------NISSIFNGVFQTLF----SLRSIDLSHNSMREIK-SS 503
            :..| |..|:...|..:|:|:|      .|..::.....:|.    .||::||:.:.:..:. .|
  Rat   212 SSTP-NTKPRTPFLEVLDLSYNLQLKQAGIRDLYGLTLHSLILDGTPLRALDLTSSGLLHLHFLS 275

  Fly   504 TFGT----LPT-------LLEMDLSHNELVSVV-RGSLAKLTSLRQLYLNNNQLEKLFQLPI--- 553
            ..||    ||.       |..:||..|::.::: .|.:..|.:|:.|.|::|.|:   .||:
  Rat   276 LVGTGIEKLPASVTGFSELCALDLGKNQIQNILGNGDILGLKALKFLSLHDNHLQ---SLPVRFL 337

  Fly   554 ----SLNELYFSHNRL---TNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQN 611
                .|.:|..|.|:|   ..:|.|.:  ..:|..||||||||.:...| :|:.|..:|.|.|..
  Rat   338 RTLPQLQKLNLSMNKLGPILELPEGLF--STNLTVLDLSHNQLCEIPRG-NFSFLSQLQELWLSG 399

  Fly   612 NGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQL 676
            |.||....:::..:..|:.|.|..|.|..|:......||.|..|||.|..::.||....:|...|
  Rat   400 NNISSLSNESLQGLRWLRTLDLSWNQIKVLKPGWLSHLPALTTLNLLGTYLEHISGTQLQGPKML 464

  Fly   677 LTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVL-------DDLLSLETLDLSH 734
            ..|.|.|             .|:|....|.|..|..|:.:....:       :..|.||.|.|..
  Rat   465 RHLQLGS-------------FPTLEIYRLWFPMLLSLEIQAETYIQFMVPSGEPFLFLENLTLET 516

  Fly   735 NRISFVTKKT---FPSHQYIPYNLRNLNL-SYNL--------------MPILTYDITFGTKKLVR 781
            :.:....|.|   |||       ||.|.| .|::              :|:|.|...: .:....
  Rat   517 SNLLLEPKTTTIHFPS-------LRRLTLRGYSIFLSTSQLQSFFPPQLPLLEYFFVW-CRNDDA 573

  Fly   782 LDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFAN 846
            :|:...::..||      ...|.:|:..| |.|.:|.|..:.::|| |..|.|||..:.:|..::
  Rat   574 VDLHLFEMPRLR------VLELGNLNFFY-ESSTVKLEMLLNEVPQ-LQVLALSHLNLKNLSVSS 630

  Fly   847 LVKVKSLKYVDL-TNNSLEDVPASIVGSMRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIAGEDL 910
            ...::|||.:.| :..:||         |.:..|.|:...|.:.        ||. ..|.|.:
  Rat   631 FKGLQSLKLLLLNSERALE---------MNSNLQELIPQIPQYV--------YFS-DVTFACQ-- 675

  Fly   911 KSIYCGTPALIKDKQLISLDDEYLHCAEDEQEMYKGIDYEQLTDVRFREVKTNKA------GMLT 969
                |.|..|  :.......:.:::..|....|....||.:  .:.|..:.||..      |.||
  Rat   676 ----CETSWL--ESWATRAPNTFVYGLEKPICMANASDYSK--TLLFSFLATNCPHGTEFWGFLT 732

  Fly   970 ------------------------------LCWYVSG---FSDVSDFHVYIRSSSNDVLHQSDYA 1001
                                          .||:..|   .....::.|:|.....|    .|:.
  Rat   733 SFSLLLLLIILPLISCHKWSWLHHLWTLFHTCWWKLGGHRLRGQFNYDVFISYCEED----QDWV 793

  Fly  1002 YNNRTAQIPV-EELSTLGEEKLRGAEICIVSRD-SDGNTR 1039
            ...   .:|| |:....||    |..:|:.:|| ..||.|
  Rat   794 LEE---LVPVLEKAPPEGE----GLRLCLPARDFGIGNDR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	52/247 (21%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566	3/8 (38%)
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566	12/70 (17%)
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380	5/21 (24%)
		leucine-rich repeat	371..390	CDD:275380	4/22 (18%)
		leucine-rich repeat	391..414	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..438	CDD:275380	5/27 (19%)
		LRR_8	437..495	CDD:290566	16/71 (23%)
		leucine-rich repeat	439..462	CDD:275380	5/26 (19%)
		leucine-rich repeat	463..486	CDD:275380	6/32 (19%)
		LRR_RI	486..738	CDD:238064	78/281 (28%)
		LRR_8	486..545	CDD:290566	19/71 (27%)
		leucine-rich repeat	487..510	CDD:275380	8/27 (30%)
		leucine-rich repeat	511..534	CDD:275380	6/23 (26%)
		leucine-rich repeat	535..554	CDD:275380	7/25 (28%)
		LRR_8	554..614	CDD:290566	23/62 (37%)
		leucine-rich repeat	555..578	CDD:275380	7/25 (28%)
		leucine-rich repeat	579..603	CDD:275380	12/23 (52%)
		leucine-rich repeat	604..627	CDD:275380	6/22 (27%)
		LRR_8	626..710	CDD:290566	24/83 (29%)
		leucine-rich repeat	628..649	CDD:275380	6/20 (30%)
		leucine-rich repeat	652..672	CDD:275380	7/19 (37%)
		LRR_8	698..765	CDD:290566	21/91 (23%)
		leucine-rich repeat	700..726	CDD:275380	5/32 (16%)
		leucine-rich repeat	727..745	CDD:275380	6/20 (30%)
		LRR_8	777..839	CDD:290566	17/61 (28%)
		leucine-rich repeat	779..802	CDD:275380	3/22 (14%)
		leucine-rich repeat	829..852	CDD:275380	6/22 (27%)
Tlr11	NP_001138251.2	leucine-rich repeat	111..133	CDD:275380	2/21 (10%)
		LRR_RI	<179..427	CDD:238064	66/254 (26%)
		leucine-rich repeat	224..246	CDD:275380	5/21 (24%)
		leucine-rich repeat	248..270	CDD:275380	5/21 (24%)
		LRR_8	270..329	CDD:290566	15/58 (26%)
		leucine-rich repeat	271..293	CDD:275380	5/21 (24%)
		leucine-rich repeat	294..318	CDD:275380	6/23 (26%)
		LRR_8	319..378	CDD:290566	21/63 (33%)
		leucine-rich repeat	319..342	CDD:275380	7/25 (28%)
		leucine-rich repeat	343..367	CDD:275380	7/25 (28%)
		LRR_8	366..426	CDD:290566	22/60 (37%)
		leucine-rich repeat	368..391	CDD:275380	12/23 (52%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		LRR_8	416..471	CDD:290566	19/54 (35%)
		leucine-rich repeat	416..437	CDD:275380	6/20 (30%)
		leucine-rich repeat	440..463	CDD:275380	8/22 (36%)
		leucine-rich repeat	533..583	CDD:275380	9/50 (18%)
		leucine-rich repeat	584..612	CDD:275380	9/34 (26%)
		leucine-rich repeat	613..633	CDD:275380	6/19 (32%)
		TIR_2	781..>861	CDD:290400	16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000