Protein Alignment conv and tlr3

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_001013287.2
• Gene: tlr3 / 403126
• ZFINID: ZDB-GENE-040219-7
• Length: 903
• Species: Danio rerio
• Alignment Length: 729
• Identity: 179/729 - (24%)
• Similarity: 296/729 - (40%)
• Gaps: 153/729 - (20%)

  Fly   224 LEVLDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDAN 288
            :..||:|||::|.|.:.|:  .|.|...:.|:|:|:.:.:........|:.|::.|||:..:...
Zfish    56 ITTLDVSHNRLKTLSSLHM--YTNLVNIDASYNSLAGIEKDLCLSLPHLQFLNVQHNQVYLISEK 118

  Fly   289 SFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLDLAENN 353
            :.:....|.:|.||||.|...|. .|..:..:..:|::||:|...:.....|:..:..|.|:.||
Zfish   119 NLKNCFHLTQLDLSDNKLKLQGE-PFSLLKNLTWLDVSRNKLTSAKLGTEPQLPNLVTLVLSGNN 182

  Fly   354 ITKIEKNSFKDIYQA----IINVSHNALELIETAAFENCVNITVLDLSHNRL-ANFSRRSFDETT 413
            |..:::|.|..:..:    ::.:|...|:.:|...|:....::.|.|..::| :.|:...|:|..
Zfish   183 INILQENDFSFLSNSSSFRVLILSSLILKKVENGCFKAIDTLSDLVLDSSKLTSQFTTSLFEELA 247

  Fly   414 FATYFQLSYNNLTNLAQIPIQNMT--GLKVLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSI 476
            ......||   |.:..|:.:.|.|  ||:..                   ::..:|:|.|.||.|
Zfish   248 DTALRNLS---LKSTEQVTLSNTTFQGLEKT-------------------KITVLDLSENRISKI 290

  Fly   477 FNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDL------SHNELVSVVRGSLAKLTSL 535
            .:|.||.|..|..:.|.||::|.:.:.:|..|..|.:::|      ||..|..:...|...|..|
Zfish   291 VDGAFQWLPQLEFLSLEHNTIRHLTNDSFSGLGNLRQLNLRKALIKSHASLPVIDDFSFQHLVQL 355

  Fly   536 RQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTG 600
            ..|.:.|....:|.:                .|.||    :.:|..||||.          |.||
Zfish   356 EYLCMANTAFRELTE----------------QIFSG----LRNLKTLDLSW----------SITG 390

  Fly   601 LLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDI 665
            :..|                             .|.....|:.|     |:|..|||.|..:..:
Zfish   391 IKTV-----------------------------TNKTFAGLQES-----PLLQTLNLTGMGINKL 421

  Fly   666 SKRAFEGLLQLLTLNLSSNGI-QTLQNDIFVGLPSLRNLDLSFN----SLT-------------K 712
            ...||..|..|..|.:|.|.| |.||.:.|.||.:::.:|:|.|    |||             |
Zfish   422 EPGAFSSLGNLSNLLMSRNFINQQLQGNEFKGLSNIKEIDMSINQQSISLTNASFVHVSTLRTLK 486

  Fly   713 LDNKTNGVLD-------DLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLM----- 765
            |.....|.||       .|::|..||||:|.|:.:.......    .|||:.:.:.:|.:
Zfish   487 LGRALKGTLDMEPSPFRPLVNLTILDLSNNNIANINADLLEG----LYNLKVVKMQHNNLARLWK 547

  Fly   766 ------PIL-TYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIF 823
                  |:| ..|.|    .|..|::.:|.|:::.......|:.|..|.:..|.|..|.:.  :|
Zfish   548 MANPGGPVLFLKDAT----NLSYLNLDYNGIDEIPPNAFRGFSELHELSLRGNLLDQLHAS--VF 606

  Fly   824 DLPQNLSWLDLSHNKIYHLPFANL-VKVKSLKYVDLTNNSLEDVPASIV--GSMRNGSQVLLAGN 885
            |...:|.:|.|..|.|..:..|.. |.:..||.:::.:|..:....||:  ....|.:...:.|.
Zfish   607 DDLNSLKYLHLQKNLITSVQRATFGVPLSKLKELNMDHNPFDCTCESILWFSEWLNSTNTSVPGF 671

  Fly   886 PLHCGCNARPLKYF 899
            |....||. |..||
Zfish   672 PQSYICNT-PNAYF 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		PPP1R42	191..359	CDD:455733	37/134 (28%)
		LRR_8	198..258	CDD:404697	12/33 (36%)
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	224..271	CDD:275380	13/46 (28%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		leucine-rich repeat	296..319	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..343	CDD:275380	5/20 (25%)
		leucine-rich repeat	344..367	CDD:275380	7/22 (32%)
		LRR	346..718	CDD:443914	96/402 (24%)
		leucine-rich repeat	371..390	CDD:275380	4/18 (22%)
		leucine-rich repeat	391..414	CDD:275380	6/23 (26%)
		leucine-rich repeat	416..438	CDD:275380	6/23 (26%)
		leucine-rich repeat	439..462	CDD:275380	1/22 (5%)
		leucine-rich repeat	463..486	CDD:275380	10/22 (45%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	7/28 (25%)
		leucine-rich repeat	535..554	CDD:275380	4/18 (22%)
		leucine-rich repeat	555..578	CDD:275380	3/22 (14%)
		leucine-rich repeat	579..603	CDD:275380	8/23 (35%)
		leucine-rich repeat	604..627	CDD:275380	1/22 (5%)
		leucine-rich repeat	628..649	CDD:275380	3/20 (15%)
		PPP1R42	631..849	CDD:455733	68/255 (27%)
		leucine-rich repeat	652..672	CDD:275380	7/19 (37%)
		leucine-rich repeat	700..726	CDD:275380	12/49 (24%)
		leucine-rich repeat	727..745	CDD:275380	7/17 (41%)
		leucine-rich repeat	779..802	CDD:275380	5/22 (23%)
		leucine-rich repeat	829..852	CDD:275380	7/23 (30%)
tlr3	NP_001013287.2	LRR	<54..436	CDD:443914	110/468 (24%)
		leucine-rich repeat	57..77	CDD:275380	8/21 (38%)
		leucine-rich repeat	78..101	CDD:275380	4/22 (18%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		leucine-rich repeat	126..148	CDD:275380	9/22 (41%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..276	CDD:275380	25/124 (20%)
		leucine-rich repeat	278..300	CDD:275380	10/21 (48%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..354	CDD:275380	7/28 (25%)
		leucine-rich repeat	355..378	CDD:275380	7/42 (17%)
		LRR	368..>666	CDD:443914	88/371 (24%)
		leucine-rich repeat	379..404	CDD:275380	11/63 (17%)
		leucine-rich repeat	408..431	CDD:275380	8/22 (36%)
		leucine-rich repeat	432..456	CDD:275380	11/23 (48%)
		leucine-rich repeat	457..507	CDD:275380	12/49 (24%)
		leucine-rich repeat	482..498	CDD:275380	5/15 (33%)
		leucine-rich repeat	508..531	CDD:275380	7/26 (27%)
		leucine-rich repeat	532..563	CDD:275380	6/34 (18%)
		leucine-rich repeat	564..587	CDD:275380	5/22 (23%)
		leucine-rich repeat	588..611	CDD:275380	7/24 (29%)
		leucine-rich repeat	612..630	CDD:275380	6/17 (35%)
		Tlr3_TMD	698..730	CDD:465595
		TIR	756..898	CDD:214587