DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Toll-6

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	243/1002 - (24%)
Similarity:	412/1002 - (41%)	Gaps:	186/1002 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 HAFQQLPKDLFAGQEIANS---LGIIRVTNGNLSDLPIETFQPLRKLKTL--------------- 203
            |..:.|.......|::::|   :|...|:|..|    ::...|.|.|:.|
  Fly    19 HTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQL----MQPSTPARTLRPLTAGAGGDPSLYDAPD 79

  Fly   204 DLHGNQLENLKRNQFK---NLRELEVLDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGT 265
            |.|......|.:.:..   |||.:. .:........:.|:|...|..|  ||....|.|.|...:
  Fly    80 DCHFMPAAGLDQPEIALTCNLRTVN-SEFDTTNFSVIPAEHTIALHIL--CNDEIMAKSRLEAQS 141

  Fly   266 FARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFL-SDNVL-----TDIGRGTFGSIARIGTID 324
            ||....|:.|.:.:.::.||......|:..||.|.| :.|:|     .:|....|....|:..:|
  Fly   142 FAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLD 206

  Fly   325 LARNRLKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHNALELIETA-----A 384
            |:.|.:..:...:|..::.:..|:::||.:..:.:..|:|..:...|.|..:....|:|     :
  Fly   207 LSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSS 271

  Fly   385 FENC-VNITVLDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNS 448
            ..:| :::..||:|||.........|..........::.|.::.:|...:..:..|::||.|.|.
  Fly   272 STSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK 336

  Fly   449 ITEIPKNCFPKLYE-LHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMRE--IKSSTFGTLPT 510
            |..:|...|.:..: :..:.:.:|:||.:...:|..|..|:::|||.|.:..  |..:||..|..
  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIR 401

  Fly   511 LLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPV 575
            |:.::||||:|..:.....:.|.:|:.|.|.:||||                    ||.:.|:..
  Fly   402 LVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLE--------------------NIAADTFAP 446

  Fly   576 MNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNN--- 637
            ||:|..|.||||:| ..|:..:..||.|:..|.|.||.:.....||....|.||.|:|..|.
  Fly   447 MNNLHTLLLSHNKL-KYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKT 510

  Fly   638 --------------------ITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLS 682
                                ||.:|.|||..|..|:.|.|.||.:::|:...|..|..|..|||:
  Fly   511 VPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLA 575

  Fly   683 SNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRI-SFVTKKTFP 746
            .|.|..::...|....|::.:.|..|.|    |..||:..::.||..|::|.||: ||
  Fly   576 RNRIAVVEPGAFEMTSSIQAVRLDGNEL----NDINGLFSNMPSLLWLNISDNRLESF------- 629

  Fly   747 SHQYIPYNLRNLNLSYNLMPILTYDITFGTK---KLVRLDVSHNQINDLRRGVISNFTSLQSLDM 808
            .:.::|..|:.|:|..|.:..|:.  .||..   ||..||||.||:..:....|.|  |::.|.:
  Fly   630 DYGHVPSTLQWLDLHKNRLSSLSN--RFGLDSELKLQTLDVSFNQLQRIGPSSIPN--SIELLFL 690

  Fly   809 SYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLEDVPASIVGS 873
            :.|.::.:  :...|....||:.:||..|:|      ..:.:|||:.:.:..:  ..:|...:|
  Fly   691 NDNLITTV--DPDTFMHKTNLTRVDLYANQI------TTLDIKSLRILPVWEH--RALPEFYIG- 744

  Fly   874 MRNGSQVLLAGNPLHCGCN---ARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLH 935
                      |||..|.||   .:.:.:...:|.....||::|||        |.|.:.:..|:.
  Fly   745 ----------GNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYC--------KLLNNRERAYIP 791

  Fly   936 CAEDEQEMYKGIDYEQLTDVRFREVKTNKAGMLTLCWYVSGFSDVSD-----------FHVYIRS 989
            ..|.|.:.:               :.|.|.....:| :...| |..|           ||  .::
  Fly   792 LIEAEPKHF---------------LCTYKTHCFAVC-HCCEF-DACDCEMTCPTNCTCFH--DQT 837

  Fly   990 SSNDVLHQSDYAYNNRTAQIPVEELSTLGEEKLRGAEICIVSRDSDGNTRKWFSGQCQQLPSLKR 1054
            .|.:::..|..||:....::|::.           :|:.|     |||.....:|  ......|.
  Fly   838 WSTNIVECSGAAYSEMPRRVPMDT-----------SELYI-----DGNNFVELAG--HSFLGRKN 884

  Fly  1055 PRTFFFGNFQVRGGVSRTSSSLPRCLL 1081
            ....:..|..|....:.|.|.|.|.|:
  Fly   885 LAVLYANNSNVAHIYNTTFSGLKRLLI 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380	3/17 (18%)
		leucine-rich repeat	176..199	CDD:275380	5/22 (23%)
		LRR_8	198..258	CDD:290566	15/77 (19%)
		leucine-rich repeat	200..223	CDD:275380	7/40 (18%)
		LRR_RI	201..545	CDD:238064	87/376 (23%)
		leucine-rich repeat	224..271	CDD:275380	11/46 (24%)
		LRR_8	245..306	CDD:290566	19/61 (31%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		LRR_8	296..354	CDD:290566	16/63 (25%)
		leucine-rich repeat	296..319	CDD:275380	8/28 (29%)
		LRR_8	322..401	CDD:290566	19/84 (23%)
		leucine-rich repeat	322..343	CDD:275380	4/20 (20%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	371..390	CDD:275380	5/24 (21%)
		leucine-rich repeat	391..414	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..438	CDD:275380	2/21 (10%)
		LRR_8	437..495	CDD:290566	17/58 (29%)
		leucine-rich repeat	439..462	CDD:275380	8/22 (36%)
		leucine-rich repeat	463..486	CDD:275380	5/22 (23%)
		LRR_RI	486..738	CDD:238064	86/277 (31%)
		LRR_8	486..545	CDD:290566	20/60 (33%)
		leucine-rich repeat	487..510	CDD:275380	9/24 (38%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		leucine-rich repeat	535..554	CDD:275380	7/18 (39%)
		LRR_8	554..614	CDD:290566	20/59 (34%)
		leucine-rich repeat	555..578	CDD:275380	4/22 (18%)
		leucine-rich repeat	579..603	CDD:275380	10/23 (43%)
		leucine-rich repeat	604..627	CDD:275380	6/22 (27%)
		LRR_8	626..710	CDD:290566	31/106 (29%)
		leucine-rich repeat	628..649	CDD:275380	11/43 (26%)
		leucine-rich repeat	652..672	CDD:275380	7/19 (37%)
		LRR_8	698..765	CDD:290566	20/67 (30%)
		leucine-rich repeat	700..726	CDD:275380	6/25 (24%)
		leucine-rich repeat	727..745	CDD:275380	7/18 (39%)
		LRR_8	777..839	CDD:290566	19/64 (30%)
		leucine-rich repeat	779..802	CDD:275380	9/22 (41%)
		leucine-rich repeat	829..852	CDD:275380	5/22 (23%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		LRR_8	171..236	CDD:290566	16/64 (25%)
		leucine-rich repeat	172..201	CDD:275380	8/28 (29%)
		leucine-rich repeat	202..278	CDD:275380	14/75 (19%)
		leucine-rich repeat	229..249	CDD:275380	5/19 (26%)
		LRR_RI	278..468	CDD:238064	57/210 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	301..386	CDD:290566	20/84 (24%)
		leucine-rich repeat	303..326	CDD:275380	2/22 (9%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	124/422 (29%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	76/249 (31%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	11/42 (26%)
		leucine-rich repeat	450..473	CDD:275380	10/23 (43%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..518	CDD:275380	5/19 (26%)
		leucine-rich repeat	521..544	CDD:275380	7/22 (32%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	7/22 (32%)
		leucine-rich repeat	593..615	CDD:275380	6/25 (24%)
		leucine-rich repeat	616..637	CDD:275380	8/27 (30%)
		leucine-rich repeat	638..662	CDD:275380	7/25 (28%)
		leucine-rich repeat	663..684	CDD:275380	9/22 (41%)
		leucine-rich repeat	685..708	CDD:275380	3/24 (13%)
		leucine-rich repeat	709..728	CDD:275380	7/24 (29%)
		LRR_8	883..943	CDD:290566	8/29 (28%)
		leucine-rich repeat	885..908	CDD:275380	5/22 (23%)
		leucine-rich repeat	909..932	CDD:275380	1/3 (33%)
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910