DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Lrt

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	153/613 - (24%)
Similarity:	247/613 - (40%)	Gaps:	99/613 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 LSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLP---- 552
            ::.:|.|:.|:....:||  |.:|      .:::......:|..|     |.:||....||
  Fly   103 VNKSSPRKRKAEQVSSLP--LPVD------DALMEWKCPNITGTR-----NAELECGCDLPHTLR 154

  Fly   553 --ISLNELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQ---LGDT--LNGESFTGLLVVQRLKLQ 610
              |.|:.:....:||...|       .|:..||.|...   |.|.  .:..|..||::      .
  Fly   155 CNIDLHGMMLLADRLRTSP-------YSISLLDCSLRNVTFLSDAKIFDNVSLHGLVI------S 206

  Fly   611 NNGISQPPKDA-VAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLL 674
            :..|.:..|.| :.:...||.|.|..|.:.::..:|...|..|..|:|..|::|.:....|.||.
  Fly   207 SGEIKRVHKSAFLGIRGPLQALGLPGNALMSVPWNALSTLSALERLDLANNKIKALGTADFVGLT 271

  Fly   675 QLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISF 739
            .|:.|.||:|.|.::....||.|..|..|.|..|.|......... |...|||..|||..|.::.
  Fly   272 SLVYLELSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYAQSLRS-LSQCLSLRQLDLQANNLNG 335

  Fly   740 -VTKKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSL 803
             ::::|.|..:    ||.:|||:.||:..:.........:||.|.:.||||:.|:........:|
  Fly   336 PLSEQTLPGMR----NLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGAL 396

  Fly   804 QSLDMSYNELSNLKSE--EHIFDLPQNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNNSLEDV 866
            .|||:|||.:..:.|.  :|:    ..|:.|||:||.:..|....:..:.||:.:.|..|.:..|
  Fly   397 DSLDLSYNGIVAISSASLQHL----SRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIV 457

  Fly   867 PASIVGSMRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDD 931
            ..:.:...|....:.:..|||.|.|:.||...: ||::.....| |..|.||..::...|:.:..
  Fly   458 ARNAMDGARELESLQMQENPLSCDCSIRPFAEW-LQESQLHSSL-SASCVTPPRLEGAPLLQVPV 520

  Fly   932 EYLHCAEDEQEMYKGIDYEQL----------------TDVRFREVKTNKAGMLTLCWYVSGFSDV 980
            |.|.|..|..|.......:.|                .::...|:..:....|.|.|.::  ...
  Fly   521 ETLSCDMDNVEKDNANIMQHLETLAKPNQTSPIKDLSEEIILHELHFSTDYGLILTWLLN--LSK 583

  Fly   981 SDF-----HVYIRSSSNDVL------H-QSDYAYNNRTAQIPVEELSTL--GEEKLRGAEICIV- 1030
            .|:     .||.....|::|      | :|.......|..:.|.:.|:|  ||    ....|:|
  Fly   584 KDYMCDAIFVYKEEHINEILIDNSPIHCESKVVNGQNTVSVIVPDSSSLEIGE----SYRFCLVM 644

  Fly  1031 ----SRDSDGNTRKWFSGQCQQLPSLKR 1054
                ..||:.|.      .|..:..|:|
  Fly   645 IQEQKPDSELNI------GCSNITRLER 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	10/52 (19%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380
		leucine-rich repeat	416..438	CDD:275380
		LRR_8	437..495	CDD:290566	0/2 (0%)
		leucine-rich repeat	439..462	CDD:275380
		leucine-rich repeat	463..486	CDD:275380
		LRR_RI	486..738	CDD:238064	68/257 (26%)
		LRR_8	486..545	CDD:290566	10/52 (19%)
		leucine-rich repeat	487..510	CDD:275380	4/17 (24%)
		leucine-rich repeat	511..534	CDD:275380	2/22 (9%)
		leucine-rich repeat	535..554	CDD:275380	6/24 (25%)
		LRR_8	554..614	CDD:290566	13/64 (20%)
		leucine-rich repeat	555..578	CDD:275380	4/22 (18%)
		leucine-rich repeat	579..603	CDD:275380	8/28 (29%)
		leucine-rich repeat	604..627	CDD:275380	3/23 (13%)
		LRR_8	626..710	CDD:290566	28/83 (34%)
		leucine-rich repeat	628..649	CDD:275380	6/20 (30%)
		leucine-rich repeat	652..672	CDD:275380	6/19 (32%)
		LRR_8	698..765	CDD:290566	21/67 (31%)
		leucine-rich repeat	700..726	CDD:275380	6/25 (24%)
		leucine-rich repeat	727..745	CDD:275380	5/18 (28%)
		LRR_8	777..839	CDD:290566	23/63 (37%)
		leucine-rich repeat	779..802	CDD:275380	8/22 (36%)
		leucine-rich repeat	829..852	CDD:275380	7/22 (32%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	54/196 (28%)
		leucine-rich repeat	179..199	CDD:275378	5/19 (26%)
		leucine-rich repeat	200..223	CDD:275380	5/28 (18%)
		leucine-rich repeat	225..248	CDD:275380	7/22 (32%)
		LRR_8	249..307	CDD:290566	21/57 (37%)
		leucine-rich repeat	249..272	CDD:275380	8/22 (36%)
		LRR_RI	<270..479	CDD:238064	64/217 (29%)
		leucine-rich repeat	273..296	CDD:275380	9/22 (41%)
		leucine-rich repeat	297..322	CDD:275380	6/25 (24%)
		LRR_8	322..382	CDD:290566	20/63 (32%)
		leucine-rich repeat	323..347	CDD:275380	7/27 (26%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		LRR_8	370..428	CDD:290566	21/61 (34%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	9/26 (35%)
		LRR_8	418..478	CDD:290566	14/59 (24%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRRCT	476..526	CDD:214507	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910