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Protein Alignment conv and IGFALS

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001139478.1	Gene:	IGFALS / 3483	HGNCID:	5468	Length:	643	Species:	Homo sapiens

Alignment Length:	767	Identity:	184/767 - (23%)
Similarity:	282/767 - (36%)	Gaps:	251/767 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 KTLDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGT 265
            :.|.|.||.|.::....|:||..|..|::...|:..||.|.:..|..|...::..|.|..|:.||
Human   115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGT 179

  Fly   266 FARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRL 330
            ||....|..|.||:|:::||:...|.|:                     ||
Human   180 FAHTPALASLGLSNNRLSRLEDGLFEGL---------------------GS-------------- 209

  Fly   331 KKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHNALELIETAAFENCVNITVLD 395
                           |.||                     |:..|:|.::..|||....::..|.
Human   210 ---------------LWDL---------------------NLGWNSLAVLPDAAFRGLGSLRELV 238

  Fly   396 LSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNSITEIPKNCFPKL 460
            |:.||||              |.|
Human   239 LAGNRLA--------------YLQ----------------------------------------- 248

  Fly   461 YELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVV 525
                         .::|:|    |..||.:|||.|::|.||::.|..||.|.::.|..|.:.:|.
Human   249 -------------PALFSG----LAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVA 296

  Fly   526 RGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLG 590
            .|:...|.:||                                            :||||||::.
Human   297 PGAFLGLKALR--------------------------------------------WLDLSHNRVA 317

  Fly   591 DTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLFEL 655
            ..|. ::|.|||                        .|:.|.|.:|.|.:|....|..|..|.||
Human   318 GLLE-DTFPGLL------------------------GLRVLRLSHNAIASLRPRTFKDLHFLEEL 357

  Fly   656 NLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGV 720
            .|..|:::.:::|:||||.||..|.|..|.:|.::...|:||.::..::||.|.|..|..:   |
Human   358 QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQ---V 419

  Fly   721 LDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVS 785
            ...|..|.:|.|..:.:..:...||....    .||.|.|..|.:..:.....:|..:|:.||::
Human   420 FRGLGKLHSLHLEGSCLGRIRPHTFTGLS----GLRRLFLKDNGLVGIEEQSLWGLAELLELDLT 480

  Fly   786 HNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFANLVKV 850
            .||:..|...:......|:.|.:|.|.|:.|.::  .....|...|||:|||::..||.:.|..:
Human   481 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPL 543

  Fly   851 KSLKYVDLTNNSLEDVPASIVGSMRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIA--------- 906
            ..|:|:.|.||||........|..|    :.|.|||..|||..:.|:.|.||...|
Human   544 GRLRYLSLRNNSLRTFTPQPPGLER----LWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 604

  Fly   907 -GEDLKSIYCGTPALIKDKQLISLDDEYLHCAEDEQEMYKGIDYEQLTDVRF 957
             |:|     |..||...:.         :.||...:.:  |:|...|::..|
Human   605 EGDD-----CQPPAYTYNN---------ITCASPPEVV--GLDLRDLSEAHF 640

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.