Protein Alignment conv and LRRTM3

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_821079.3
• Gene: LRRTM3 / 347731
• HGNCID: 19410
• Length: 581
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 102/396 - (25%)
• Similarity: 170/396 - (42%)
• Gaps: 80/396 - (20%)

  Fly   558 LYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKL-QNNGISQPPKDA 621
            :|....:|..|||.   :....:.|.|.:|.|               |:||. |..|::|
Human    45 VYCESQKLQEIPSS---ISAGCLGLSLRYNSL---------------QKLKYNQFKGLNQ----- 86

  Fly   622 VAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGI 686
                  |.:|:|::|:|:                        :|.:.||.|:.:|..|.||||.|
Human    87 ------LTWLYLDHNHIS------------------------NIDENAFNGIRRLKELILSSNRI 121

  Fly   687 QTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYI 751
            ....|:.|..:.:|||||||:|.|..|.::....|..||||.   |..|.:..:..:.|...:
Human   122 SYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLH---LRSNSLRTIPVRIFQDCR-- 181

  Fly   752 PYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNL 816
              ||..|:|.||.:..|..::..|..:|..|.:.|||.:.|...:.....|||:|.:.:|::|
Human   182 --NLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKIS-- 242

  Fly   817 KSEEHIFDLPQNLSW-------LDLSHNKIYHLPFANLVK-VKSLKYVDLTNNSLEDVPASIVGS 873
                   .:.|.:||       ||||.|:|......::.: |.:|:.::|.:|.|..:...|:.|
Human   243 -------VIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDS 300

  Fly   874 MRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLHCAE 938
            ..:.:.:.||||...|..|...|..::  ::..|....:|.|.:|..::...:|.....|..|.:
Human   301 WISLNDISLAGNIWECSRNICSLVNWL--KSFKGLRENTIICASPKELQGVNVIDAVKNYSICGK 363

  Fly   939 DEQEMY 944
            ...|.:
Human   364 STTERF 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		PPP1R42	191..359	CDD:455733
		LRR_8	198..258	CDD:404697
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	224..271	CDD:275380
		leucine-rich repeat	272..295	CDD:275380
		leucine-rich repeat	296..319	CDD:275380
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		LRR	346..718	CDD:443914	43/160 (27%)
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380
		leucine-rich repeat	416..438	CDD:275380
		leucine-rich repeat	439..462	CDD:275380
		leucine-rich repeat	463..486	CDD:275380
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..554	CDD:275380
		leucine-rich repeat	555..578	CDD:275380	5/19 (26%)
		leucine-rich repeat	579..603	CDD:275380	4/23 (17%)
		leucine-rich repeat	604..627	CDD:275380	6/23 (26%)
		leucine-rich repeat	628..649	CDD:275380	5/20 (25%)
		PPP1R42	631..849	CDD:455733	64/224 (29%)
		leucine-rich repeat	652..672	CDD:275380	3/19 (16%)
		leucine-rich repeat	700..726	CDD:275380	12/25 (48%)
		leucine-rich repeat	727..745	CDD:275380	3/17 (18%)
		leucine-rich repeat	779..802	CDD:275380	6/22 (27%)
		leucine-rich repeat	829..852	CDD:275380	9/30 (30%)
LRRTM3	NP_821079.3	LRRNT	33..61	CDD:214470	5/18 (28%)
		LRR	59..339	CDD:443914	90/347 (26%)
		LRR 1	63..83		8/34 (24%)
		leucine-rich repeat	66..86	CDD:275380	9/34 (26%)
		LRR 2	86..107		9/55 (16%)
		leucine-rich repeat	87..110	CDD:275380	9/46 (20%)
		LRR 3	110..131		9/20 (45%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		LRR 4	134..155		10/20 (50%)
		leucine-rich repeat	135..158	CDD:275380	11/22 (50%)
		LRR 5	158..179		7/23 (30%)
		leucine-rich repeat	159..182	CDD:275380	7/29 (24%)
		LRR 6	182..203		7/20 (35%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR 7	206..226		6/19 (32%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		LRR 8	230..251		8/29 (28%)
		leucine-rich repeat	231..254	CDD:275380	8/31 (26%)
		LRR 9	254..275		6/20 (30%)
		leucine-rich repeat	255..279	CDD:275380	7/23 (30%)
		LRR 10	279..300		5/20 (25%)
		leucine-rich repeat	280..300	CDD:275380	5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..408