DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and Nrros

DIOPT Version :10

Sequence 1:NP_610948.2 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_001020166.1 Gene:Nrros / 303875 RGDID:1310771 Length:692 Species:Rattus norvegicus


Alignment Length:676 Identity:164/676 - (24%)
Similarity:259/676 - (38%) Gaps:219/676 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 GILGKAKELVIDGHAFQQLPKDLFAGQEIANSLGIIRVTNGNLSDLPIETFQPLRKLKTLDLHGN 208
            |:...::.||:|                 ||.|.::  .|.:|...|        :|:.|.||..
  Rat    54 GLPAHSRMLVLD-----------------ANPLRVL--WNHSLQAYP--------RLEDLSLHSC 91

  Fly   209 QLENLKRNQFKNLRELEVLDISHNQIK---KLEAQHIADLTKLGWCNVSHNALSELSRGTFARN- 269
            .|:.:....|.....|:.|.::.|::.   |..|..:..|.:|...::|.|:|:|.......:| 
  Rat    92 HLDRISHWAFHEQGHLQNLVLADNRLSENYKESATALHTLLRLRRLDLSGNSLTEDMAALMLQNL 156

  Fly   270 SVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKKIE 334
            |.|:|:.|:.|.:.|||.:.|.|:..|..|.|..|.:.:|..|.|..:..:..::||.|.|..|.
  Rat   157 SSLEVVSLARNTLMRLDDSVFEGLERLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIV 221

  Fly   335 FQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHNALELI----ETAAFENCVNITVLD 395
            ....||:.:                          :|||:|.||..    |.||||    :.:||
  Rat   222 DFSLTQLRF--------------------------LNVSYNILEWFLAAREEAAFE----LEILD 256

  Fly   396 LSHNRL---------------------ANFSRRSFDETT---FATYFQLSYNNLTNLAQIPI--- 433
            ||||:|                     ..|.|..::.::   ....|.|...|:||:..:.:   
  Rat   257 LSHNQLLFFPLLPQCGKLHTLLLQDNSMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVSLWEE 321

  Fly   434 ---QNMTGLKVLNASYNSITEIP----------------KNCFPKLY--------ELHTIDVSHN 471
               .:::.|:.|:.|.|.:..:|                :||..||:        .|..:|:|.|
  Rat   322 FSSSDLSALRFLDMSQNQLRHLPDGFLKKTPSLSHLNLNQNCLTKLHIREHEPPGALTELDLSRN 386

  Fly   472 NISSIF--NGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNEL------------- 521
            .::.:.  .|:..:|.:||..:||.|.:..:.:..|.:..::..:|:|||::             
  Rat   387 QLAELHLAPGLTGSLKNLRVFNLSSNQLLGVPTGLFHSASSITTLDMSHNQISLCPQTVPLDWEE 451

  Fly   522 -VSVVRGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVMNSLIYLDLS 585
             .|.|  ....:.|||.|.|:...|:.|...|.                .||     ||.:||||
  Rat   452 PSSCV--DFRNMASLRSLSLDGCGLKALQDCPF----------------QGT-----SLTHLDLS 493

  Fly   586 HNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLEN----NNITTLERSAF 646
            .|           .|:|         || |..|..|||  .|||.|.|.|    :....::.|.|
  Rat   494 SN-----------WGIL---------NG-SVSPLSAVA--PTLQVLSLRNVGLGSGAAEMDFSGF 535

  Fly   647 GKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLT 711
            |.|.   ||:|.||.:....|                          |.|..:|:.|||..||||
  Rat   536 GNLR---ELDLSGNSLTSFPK--------------------------FKGSSALQTLDLRRNSLT 571

  Fly   712 KLDNKTNGVLDD--LLSLETLDLSHN 735
            .|..:   |:.:  |..|:|:.||.|
  Rat   572 ALPQR---VVSEQPLRGLQTIYLSQN 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_610948.2 leucine-rich repeat 125..148 CDD:275380 1/3 (33%)
leucine-rich repeat 150..175 CDD:275380 4/24 (17%)
leucine-rich repeat 176..199 CDD:275380 4/22 (18%)
PPP1R42 191..359 CDD:455733 42/171 (25%)
LRR_8 198..258 CDD:404697 15/62 (24%)
leucine-rich repeat 200..223 CDD:275380 6/22 (27%)
leucine-rich repeat 224..271 CDD:275380 12/50 (24%)
leucine-rich repeat 272..295 CDD:275380 9/22 (41%)
leucine-rich repeat 296..319 CDD:275380 7/22 (32%)
leucine-rich repeat 322..343 CDD:275380 7/20 (35%)
leucine-rich repeat 344..367 CDD:275380 0/22 (0%)
LRR 346..718 CDD:443914 105/449 (23%)
leucine-rich repeat 371..390 CDD:275380 11/22 (50%)
leucine-rich repeat 391..414 CDD:275380 9/46 (20%)
leucine-rich repeat 416..438 CDD:275380 5/27 (19%)
leucine-rich repeat 439..462 CDD:275380 9/46 (20%)
leucine-rich repeat 463..486 CDD:275380 6/24 (25%)
leucine-rich repeat 487..510 CDD:275380 6/22 (27%)
leucine-rich repeat 511..534 CDD:275380 6/36 (17%)
leucine-rich repeat 535..554 CDD:275380 7/18 (39%)
leucine-rich repeat 555..578 CDD:275380 2/22 (9%)
leucine-rich repeat 579..603 CDD:275380 7/23 (30%)
leucine-rich repeat 604..627 CDD:275380 7/22 (32%)
leucine-rich repeat 628..649 CDD:275380 8/24 (33%)
PPP1R42 631..849 CDD:455733 31/111 (28%)
leucine-rich repeat 652..672 CDD:275380 6/19 (32%)
leucine-rich repeat 700..726 CDD:275380 11/27 (41%)
leucine-rich repeat 727..745 CDD:275380 5/9 (56%)
leucine-rich repeat 779..802 CDD:275380
leucine-rich repeat 829..852 CDD:275380
NrrosNP_001020166.1 leucine-rich repeat 39..57 CDD:275380 1/2 (50%)
LRR 1. /evidence=ECO:0000255 58..79 8/39 (21%)
leucine-rich repeat 60..82 CDD:275380 9/48 (19%)
LRR 2. /evidence=ECO:0000255 82..103 6/20 (30%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
LRR 3. /evidence=ECO:0000255 106..127 5/20 (25%)
leucine-rich repeat 107..158 CDD:275380 12/50 (24%)
LRR 4. /evidence=ECO:0000255 133..155 5/21 (24%)
LRR <140..414 CDD:443914 74/303 (24%)
LRR 5. /evidence=ECO:0000255 158..179 8/20 (40%)
leucine-rich repeat 159..182 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000255 182..203 7/20 (35%)
leucine-rich repeat 183..206 CDD:275380 7/22 (32%)
LRR 7. /evidence=ECO:0000255 206..227 5/20 (25%)
leucine-rich repeat 207..251 CDD:275380 16/69 (23%)
LRR 8. /evidence=ECO:0000255 228..239 4/36 (11%)
LRR 9. /evidence=ECO:0000255 251..272 8/24 (33%)
leucine-rich repeat 252..273 CDD:275380 7/20 (35%)
LRR 10. /evidence=ECO:0000255 273..294 2/20 (10%)
leucine-rich repeat 274..329 CDD:275380 7/54 (13%)
LRR 293..>595 CDD:443914 92/380 (24%)
LRR 11. /evidence=ECO:0000255 329..350 5/20 (25%)
leucine-rich repeat 330..353 CDD:275380 5/22 (23%)
LRR 12. /evidence=ECO:0000255 353..374 4/20 (20%)
leucine-rich repeat 354..377 CDD:275380 4/22 (18%)
LRR 13. /evidence=ECO:0000255 377..398 5/20 (25%)
leucine-rich repeat 378..403 CDD:275380 6/24 (25%)
LRR 14. /evidence=ECO:0000255 403..424 6/20 (30%)
leucine-rich repeat 404..427 CDD:275380 6/22 (27%)
LRR 15. /evidence=ECO:0000255 427..448 4/20 (20%)
leucine-rich repeat 428..463 CDD:275380 6/36 (17%)
LRR 16. /evidence=ECO:0000255 463..484 8/36 (22%)
leucine-rich repeat 464..486 CDD:275380 9/42 (21%)
LRR 17. /evidence=ECO:0000255 486..507 13/41 (32%)
leucine-rich repeat 487..512 CDD:275380 15/47 (32%)
LRR 18. /evidence=ECO:0000255 512..533 6/20 (30%)
leucine-rich repeat 513..537 CDD:275380 7/23 (30%)
LRR 19. /evidence=ECO:0000255 537..558 9/49 (18%)
leucine-rich repeat 538..559 CDD:275380 9/49 (18%)
LRR 20. /evidence=ECO:0000255 559..580 10/23 (43%)
LRR 21. /evidence=ECO:0000255 585..605 5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

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