DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and TSKU

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001305406.1	Gene:	TSKU / 25987	HGNCID:	28850	Length:	367	Species:	Homo sapiens

Alignment Length:	319	Identity:	84/319 - (26%)
Similarity:	130/319 - (40%)	Gaps:	78/319 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 LDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNSITEIPKNCFP 458
            ||||.|||                      .:.|.:.:.....|.|..|:.|:|.:|.|....|.
Human    77 LDLSSNRL----------------------EMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFS 119

  Fly   459 KLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTFGT--LPTLLEMDLSHNEL 521
            :|..|.::|:|||.::::....| |...|..::||||.:||:..|.|.|  ....|.:|||||.:
Human   120 RLRYLESLDLSHNGLTALPAESF-TSSPLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLI 183

  Fly   522 VSVV----RGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVMNSLIYL 582
            ..:|    |..|...|              :..|.::.|.|:...| |.::|         |.||
Human   184 HRLVPHPTRAGLPAPT--------------IQSLNLAWNRLHAVPN-LRDLP---------LRYL 224

  Fly   583 DLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFG 647
            .|..|.|. .:...:|.||..:..|.|                ::||       .:..|..|.|.
Human   225 SLDGNPLA-VIGPGAFAGLGGLTHLSL----------------ASLQ-------RLPELAPSGFR 265

  Fly   648 KLPVLFELNLYGN-QVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDL 705
            :||.|..|:|.|| ::.......|.||..|..|:||...:..|...:.:.||:|:::.:
Human   266 ELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSV 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	44/156 (28%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566	5/6 (83%)
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380	7/19 (37%)
		leucine-rich repeat	416..438	CDD:275380	1/21 (5%)
		LRR_8	437..495	CDD:290566	19/57 (33%)
		leucine-rich repeat	439..462	CDD:275380	8/22 (36%)
		leucine-rich repeat	463..486	CDD:275380	7/22 (32%)
		LRR_RI	486..738	CDD:238064	60/227 (26%)
		LRR_8	486..545	CDD:290566	20/64 (31%)
		leucine-rich repeat	487..510	CDD:275380	10/24 (42%)
		leucine-rich repeat	511..534	CDD:275380	9/26 (35%)
		leucine-rich repeat	535..554	CDD:275380	1/18 (6%)
		LRR_8	554..614	CDD:290566	16/59 (27%)
		leucine-rich repeat	555..578	CDD:275380	5/22 (23%)
		leucine-rich repeat	579..603	CDD:275380	9/23 (39%)
		leucine-rich repeat	604..627	CDD:275380	2/22 (9%)
		LRR_8	626..710	CDD:290566	23/81 (28%)
		leucine-rich repeat	628..649	CDD:275380	5/20 (25%)
		leucine-rich repeat	652..672	CDD:275380	6/20 (30%)
		LRR_8	698..765	CDD:290566	2/8 (25%)
		leucine-rich repeat	700..726	CDD:275380	1/6 (17%)
		leucine-rich repeat	727..745	CDD:275380
		LRR_8	777..839	CDD:290566
		leucine-rich repeat	779..802	CDD:275380
		leucine-rich repeat	829..852	CDD:275380
TSKU	NP_001305406.1	LRR_RI	52..305	CDD:238064	80/298 (27%)
		leucine-rich repeat	76..99	CDD:275380	8/43 (19%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	103..157	CDD:290566	19/54 (35%)
		leucine-rich repeat	124..145	CDD:275380	7/21 (33%)
		leucine-rich repeat	147..170	CDD:275380	10/22 (45%)
		leucine-rich repeat	171..197	CDD:275380	9/25 (36%)
		leucine-rich repeat	200..219	CDD:275380	5/19 (26%)
		LRR_8	221..279	CDD:290566	22/81 (27%)
		leucine-rich repeat	221..244	CDD:275380	9/23 (39%)
		leucine-rich repeat	245..269	CDD:275380	8/46 (17%)
		LRR_8	268..321	CDD:290566	17/52 (33%)
		leucine-rich repeat	270..294	CDD:275380	8/23 (35%)
		leucine-rich repeat	295..316	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100