Protein Alignment conv and Igfals

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_001351825.1
• Gene: Igfals / 16005
• MGIID: 107973
• Length: 638
• Species: Mus musculus
• Alignment Length: 779
• Identity: 182/779 - (23%)
• Similarity: 282/779 - (36%)
• Gaps: 266/779 - (34%)

  Fly   185 NLSDL----PIETFQPLRKLKTLDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLEAQHIADL 245
            ||:.|    |:.|       :.|.|.||.|.::....|:||..|:.|::..:.::.||.|.:..|
Mouse    99 NLTQLPDSIPVST-------RALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGL 156

  Fly   246 TKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIG 310
            ..|...::..|.|..|:.|.|.....|..|.|.:|.:.||:...|||
Mouse   157 QNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRG------------------ 203

  Fly   311 RGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHN 375
                                                                             
Mouse   204 ----------------------------------------------------------------- 203

  Fly   376 ALELIETAAFENCVNITVLDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLK 440
                                |||                                        |.
Mouse   204 --------------------LSH----------------------------------------LW 208

  Fly   441 VLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTF 505
            .||..:||:..:|...|..|..||.:.::.|.::.:...:...|..||.:|||.|::|.:|::.|
Mouse   209 DLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVF 273

  Fly   506 GTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPS 570
            ..||                                            .|.:||...|.:|.:..
Mouse   274 IHLP--------------------------------------------RLQKLYLDRNLITAVAP 294

  Fly   571 GTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLEN 635
            ..:..|.:|.:||||||::...|. ::|.|||                        .|..|.|.:
Mouse   295 RAFLGMKALRWLDLSHNRVAGLLE-DTFPGLL------------------------GLHVLRLAH 334

  Fly   636 NNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSL 700
            |.||:|....|..|..|.||.|..|:::.:.::.||||.||..|.|:.|.|..::...|.||.::
Mouse   335 NAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNV 399

  Fly   701 RNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLM 765
            ..::||.|.|..|...   |...|..|.:|.|.|:.:..:...||....    .||.|.|..|.:
Mouse   400 AVMNLSGNCLRSLPEH---VFQGLGRLHSLHLEHSCLGRIRLHTFAGLS----GLRRLFLRDNSI 457

  Fly   766 PILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLS 830
            ..:......|..:|:.||::.||:..|.|.:......|:.|.:|.|:|:.| ||:.:..| |...
Mouse   458 SSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTML-SEDVLGPL-QRAF 520

  Fly   831 WLDLSHNKIYHLP----FANLVKVKSLKYVDLTNNSLED-VPASIVGSMRNGSQVL-LAGNPLHC 889
            |||||||:: ..|    |::|.:   |:|::|.||||:. ||       :.|.:.| |..||..|
Mouse   521 WLDLSHNRL-ETPAEGLFSSLGR---LRYLNLRNNSLQTFVP-------QPGLERLWLDANPWDC 574

  Fly   890 GCNARPLKYFMLQ---------QTIA-GEDLKSIY------CGTPALIKDKQLISLDDE-YLHC 936
            .|..:.|:.|.||         ||:. |:|.:.:|      |..||.:....|..:.:. ::||
Mouse   575 SCPLKALRDFALQNPGVVPRFVQTVCEGDDCQPVYTYNNITCAGPANVSGLDLRDISETLFVHC 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380	5/17 (29%)
		PPP1R42	191..359	CDD:455733	30/167 (18%)
		LRR_8	198..258	CDD:404697	16/59 (27%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..271	CDD:275380	12/46 (26%)
		leucine-rich repeat	272..295	CDD:275380	9/22 (41%)
		leucine-rich repeat	296..319	CDD:275380	0/22 (0%)
		leucine-rich repeat	322..343	CDD:275380	0/20 (0%)
		leucine-rich repeat	344..367	CDD:275380	0/22 (0%)
		LRR	346..718	CDD:443914	76/371 (20%)
		leucine-rich repeat	371..390	CDD:275380	0/18 (0%)
		leucine-rich repeat	391..414	CDD:275380	3/22 (14%)
		leucine-rich repeat	416..438	CDD:275380	0/21 (0%)
		leucine-rich repeat	439..462	CDD:275380	8/22 (36%)
		leucine-rich repeat	463..486	CDD:275380	4/22 (18%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	0/22 (0%)
		leucine-rich repeat	535..554	CDD:275380	0/18 (0%)
		leucine-rich repeat	555..578	CDD:275380	6/22 (27%)
		leucine-rich repeat	579..603	CDD:275380	11/23 (48%)
		leucine-rich repeat	604..627	CDD:275380	0/22 (0%)
		leucine-rich repeat	628..649	CDD:275380	8/20 (40%)
		PPP1R42	631..849	CDD:455733	72/221 (33%)
		leucine-rich repeat	652..672	CDD:275380	6/19 (32%)
		leucine-rich repeat	700..726	CDD:275380	7/25 (28%)
		leucine-rich repeat	727..745	CDD:275380	4/17 (24%)
		leucine-rich repeat	779..802	CDD:275380	7/22 (32%)
		leucine-rich repeat	829..852	CDD:275380	10/26 (38%)
Igfals	NP_001351825.1	LRR	88..457	CDD:443914	123/583 (21%)
		leucine-rich repeat	92..110	CDD:275380	4/10 (40%)
		leucine-rich repeat	114..134	CDD:275380	8/19 (42%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		leucine-rich repeat	183..206	CDD:275380	10/125 (8%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..278	CDD:275380	11/66 (17%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..326	CDD:275380	12/47 (26%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	6/26 (23%)
		LRR_8	445..505	CDD:404697	17/63 (27%)
		leucine-rich repeat	447..470	CDD:275380	6/22 (27%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		leucine-rich repeat	495..516	CDD:275380	8/21 (38%)
		leucine-rich repeat	519..542	CDD:275380	10/23 (43%)
		LRR_8	521..571	CDD:404697	22/60 (37%)
		leucine-rich repeat	543..561	CDD:275380	9/24 (38%)
		LRRCT	570..613	CDD:214507	13/42 (31%)