DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and Igfals

DIOPT Version :9

Sequence 1:NP_001286416.1 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_001351825.1 Gene:Igfals / 16005 MGIID:107973 Length:638 Species:Mus musculus


Alignment Length:779 Identity:182/779 - (23%)
Similarity:282/779 - (36%) Gaps:266/779 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 NLSDL----PIETFQPLRKLKTLDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLEAQHIADL 245
            ||:.|    |:.|       :.|.|.||.|.::....|:||..|:.|::..:.::.||.|.:..|
Mouse    99 NLTQLPDSIPVST-------RALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGL 156

  Fly   246 TKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIG 310
            ..|...::..|.|..|:.|.|.....|..|.|.:|.:.||:...|||                  
Mouse   157 QNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRG------------------ 203

  Fly   311 RGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDIYQAIINVSHN 375
                                                                             
Mouse   204 ----------------------------------------------------------------- 203

  Fly   376 ALELIETAAFENCVNITVLDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQIPIQNMTGLK 440
                                |||                                        |.
Mouse   204 --------------------LSH----------------------------------------LW 208

  Fly   441 VLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTF 505
            .||..:||:..:|...|..|..||.:.::.|.::.:...:...|..||.:|||.|::|.:|::.|
Mouse   209 DLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVF 273

  Fly   506 GTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPS 570
            ..||                                            .|.:||...|.:|.:..
Mouse   274 IHLP--------------------------------------------RLQKLYLDRNLITAVAP 294

  Fly   571 GTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLEN 635
            ..:..|.:|.:||||||::...|. ::|.|||                        .|..|.|.:
Mouse   295 RAFLGMKALRWLDLSHNRVAGLLE-DTFPGLL------------------------GLHVLRLAH 334

  Fly   636 NNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSL 700
            |.||:|....|..|..|.||.|..|:::.:.::.||||.||..|.|:.|.|..::...|.||.::
Mouse   335 NAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNV 399

  Fly   701 RNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLM 765
            ..::||.|.|..|...   |...|..|.:|.|.|:.:..:...||....    .||.|.|..|.:
Mouse   400 AVMNLSGNCLRSLPEH---VFQGLGRLHSLHLEHSCLGRIRLHTFAGLS----GLRRLFLRDNSI 457

  Fly   766 PILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLS 830
            ..:......|..:|:.||::.||:..|.|.:......|:.|.:|.|:|:.| ||:.:..| |...
Mouse   458 SSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTML-SEDVLGPL-QRAF 520

  Fly   831 WLDLSHNKIYHLP----FANLVKVKSLKYVDLTNNSLED-VPASIVGSMRNGSQVL-LAGNPLHC 889
            |||||||:: ..|    |::|.:   |:|::|.||||:. ||       :.|.:.| |..||..|
Mouse   521 WLDLSHNRL-ETPAEGLFSSLGR---LRYLNLRNNSLQTFVP-------QPGLERLWLDANPWDC 574

  Fly   890 GCNARPLKYFMLQ---------QTIA-GEDLKSIY------CGTPALIKDKQLISLDDE-YLHC 936
            .|..:.|:.|.||         ||:. |:|.:.:|      |..||.:....|..:.:. ::||
Mouse   575 SCPLKALRDFALQNPGVVPRFVQTVCEGDDCQPVYTYNNITCAGPANVSGLDLRDISETLFVHC 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_001286416.1 leucine-rich repeat 125..148 CDD:275380
leucine-rich repeat 150..175 CDD:275380
leucine-rich repeat 176..199 CDD:275380 5/17 (29%)
LRR_8 198..258 CDD:290566 16/59 (27%)
leucine-rich repeat 200..223 CDD:275380 8/22 (36%)
LRR_RI 201..545 CDD:238064 55/343 (16%)
leucine-rich repeat 224..271 CDD:275380 12/46 (26%)
LRR_8 245..306 CDD:290566 16/60 (27%)
leucine-rich repeat 272..295 CDD:275380 9/22 (41%)
LRR_8 296..354 CDD:290566 0/57 (0%)
leucine-rich repeat 296..319 CDD:275380 0/22 (0%)
LRR_8 322..401 CDD:290566 3/78 (4%)
leucine-rich repeat 322..343 CDD:275380 0/20 (0%)
leucine-rich repeat 344..367 CDD:275380 0/22 (0%)
leucine-rich repeat 371..390 CDD:275380 0/18 (0%)
leucine-rich repeat 391..414 CDD:275380 3/22 (14%)
leucine-rich repeat 416..438 CDD:275380 0/21 (0%)
LRR_8 437..495 CDD:290566 17/57 (30%)
leucine-rich repeat 439..462 CDD:275380 8/22 (36%)
leucine-rich repeat 463..486 CDD:275380 4/22 (18%)
LRR_RI 486..738 CDD:238064 67/251 (27%)
LRR_8 486..545 CDD:290566 11/58 (19%)
leucine-rich repeat 487..510 CDD:275380 10/22 (45%)
leucine-rich repeat 511..534 CDD:275380 0/22 (0%)
leucine-rich repeat 535..554 CDD:275380 0/18 (0%)
LRR_8 554..614 CDD:290566 18/59 (31%)
leucine-rich repeat 555..578 CDD:275380 6/22 (27%)
leucine-rich repeat 579..603 CDD:275380 11/23 (48%)
leucine-rich repeat 604..627 CDD:275380 0/22 (0%)
LRR_8 626..710 CDD:290566 30/83 (36%)
leucine-rich repeat 628..649 CDD:275380 8/20 (40%)
leucine-rich repeat 652..672 CDD:275380 6/19 (32%)
LRR_8 698..765 CDD:290566 18/66 (27%)
leucine-rich repeat 700..726 CDD:275380 7/25 (28%)
leucine-rich repeat 727..745 CDD:275380 4/17 (24%)
LRR_8 777..839 CDD:290566 24/61 (39%)
leucine-rich repeat 779..802 CDD:275380 7/22 (32%)
leucine-rich repeat 829..852 CDD:275380 10/26 (38%)
IgfalsNP_001351825.1 LRRNT 75..113 CDD:214470 5/20 (25%)
leucine-rich repeat 92..110 CDD:275380 4/10 (40%)
PLN00113 96..>558 CDD:331614 158/690 (23%)
leucine-rich repeat 114..134 CDD:275380 8/19 (42%)
leucine-rich repeat 135..158 CDD:275380 6/22 (27%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
leucine-rich repeat 183..206 CDD:275380 10/125 (8%)
leucine-rich repeat 207..230 CDD:275380 8/22 (36%)
leucine-rich repeat 231..254 CDD:275380 4/22 (18%)
leucine-rich repeat 255..278 CDD:275380 11/66 (17%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
leucine-rich repeat 303..326 CDD:275380 12/47 (26%)
leucine-rich repeat 327..350 CDD:275380 9/22 (41%)
leucine-rich repeat 351..374 CDD:275380 9/22 (41%)
leucine-rich repeat 375..396 CDD:275380 6/20 (30%)
leucine-rich repeat 423..446 CDD:275380 6/26 (23%)
leucine-rich repeat 447..470 CDD:275380 6/22 (27%)
leucine-rich repeat 471..494 CDD:275380 7/22 (32%)
leucine-rich repeat 495..516 CDD:275380 8/21 (38%)
leucine-rich repeat 519..542 CDD:275380 10/23 (43%)
leucine-rich repeat 543..561 CDD:275380 9/24 (38%)
TPKR_C2 570..613 CDD:326558 13/42 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42484
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4879
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.940

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