DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment conv and CHADL

DIOPT Version :9

Sequence 1:NP_001286416.1 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster
Sequence 2:XP_011528235.1 Gene:CHADL / 150356 HGNCID:25165 Length:830 Species:Homo sapiens


Alignment Length:757 Identity:184/757 - (24%)
Similarity:273/757 - (36%) Gaps:204/757 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 RLYGPLFAHIKARMLIIEETPLATIEDYVFYGVNNTLEQLHLLRTNLSHVGLLGFGILGKAKELV 153
            |.:|.|...:..:..:::..|.|     .|.||.      ||...:|.|..:          |||
Human   126 RRHGGLTQRLDLQGNLLKVIPAA-----AFQGVP------HLTHLDLRHCEV----------ELV 169

  Fly   154 IDGHAFQQLPKDLFAGQEIANSLGIIRVTNGNLSDLPIETFQPLRKLKTLDLHGNQLENLKRNQF 218
            .:| ||:.|.:           |.::.:.:.:|.:||.|....|..|:.|:|.||.||.|:...|
Human   170 AEG-AFRGLGR-----------LLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTF 222

  Fly   219 KNLRELEVLDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIA 283
            ..|..|..|:::||.:..|.|.....|.::.|..:||||||.|:....|....|:.|.|.||::.
Human   223 GALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQ 287

  Fly   284 RLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKKIEFQMFTQMNYVELLD 348
            .|........|.|.||.|..|.||..|...          .||...|:::            |||
Human   288 ALPGPVLSQARGLARLELGHNPLTYAGEED----------GLALPGLREL------------LLD 330

  Fly   349 LAENNITKIEKNSFKDIYQAIINVSHNALELIETAAFENCVNITVLDLSHNRLANFS-------- 405
                                     ..||:.:...||.:|..:..|||..|:|....        
Human   331 -------------------------GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQL 370

  Fly   406 RRSFDETTFATYFQLSYNNL--------------------TNLAQIPIQNMTGLKVLNA------ 444
            ||          .:|..|.|                    ....|.| :.:.| :.|:|      
Human   371 RR----------LRLQGNPLWCGCQARPLLEWLARARVRSDGACQGP-RRLRG-EALDALRPWDL 423

  Fly   445 ---------------------------------SYNSITEIPKNCFPKLYELHTIDVSHNNISSI 476
                                             ...::...|:.|         :.|..:..||.
Human   424 RCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRAC---------VCVPESRHSSC 479

  Fly   477 FNGVFQTL-----FSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAKLTSLR 536
            .....|.:     ...:.:||..|....:..:.|..|..|:.:.|.|..:..:..|:||.|..|.
Human   480 EGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLI 544

  Fly   537 QLYLNNNQLEKLFQLPIS----LNELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGES 597
            .|||::|||..|....:.    |..||...||...:|......:.||..|.|..|.: |.|....
Human   545 YLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAV-DRLAPGD 608

  Fly   598 FTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQV 662
            ......::.:.|..|.|::....|:.....|:.|||:.|.:..:...|...||.|.||.|.||.:
Human   609 LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPL 673

  Fly   663 KDISKRAFEGL---LQLLTLNLSSNGIQTLQNDIFVGL-PSLRNLDLSFNSLTKLDNKTNGVLDD 723
            :.:...||:.:   ||.|.||  |:|::.:....|.|| |.|::|.|..|.|..|.     .|..
Human   674 RALRDGAFQPVGRSLQHLFLN--SSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP-----ALPS 731

  Fly   724 LLSLETLDLSHNRISFVTKKTFPSH---QYIPYN--LRNLNL 760
            |..||.:|||.|          |.|   |.:|.:  |..|||
Human   732 LSQLELIDLSSN----------PFHCDCQLLPLHRWLTGLNL 763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
convNP_001286416.1 leucine-rich repeat 125..148 CDD:275380 4/22 (18%)
leucine-rich repeat 150..175 CDD:275380 7/24 (29%)
leucine-rich repeat 176..199 CDD:275380 6/22 (27%)
LRR_8 198..258 CDD:290566 21/59 (36%)
leucine-rich repeat 200..223 CDD:275380 10/22 (45%)
LRR_RI 201..545 CDD:238064 89/415 (21%)
leucine-rich repeat 224..271 CDD:275380 16/46 (35%)
LRR_8 245..306 CDD:290566 22/60 (37%)
leucine-rich repeat 272..295 CDD:275380 6/22 (27%)
LRR_8 296..354 CDD:290566 14/57 (25%)
leucine-rich repeat 296..319 CDD:275380 8/22 (36%)
LRR_8 322..401 CDD:290566 15/78 (19%)
leucine-rich repeat 322..343 CDD:275380 3/20 (15%)
leucine-rich repeat 344..367 CDD:275380 3/22 (14%)
leucine-rich repeat 371..390 CDD:275380 5/18 (28%)
leucine-rich repeat 391..414 CDD:275380 7/30 (23%)
leucine-rich repeat 416..438 CDD:275380 5/41 (12%)
LRR_8 437..495 CDD:290566 11/101 (11%)
leucine-rich repeat 439..462 CDD:275380 4/61 (7%)
leucine-rich repeat 463..486 CDD:275380 4/27 (15%)
LRR_RI 486..738 CDD:238064 78/259 (30%)
LRR_8 486..545 CDD:290566 17/58 (29%)
leucine-rich repeat 487..510 CDD:275380 5/22 (23%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
leucine-rich repeat 535..554 CDD:275380 8/18 (44%)
LRR_8 554..614 CDD:290566 15/63 (24%)
leucine-rich repeat 555..578 CDD:275380 6/22 (27%)
leucine-rich repeat 579..603 CDD:275380 6/23 (26%)
leucine-rich repeat 604..627 CDD:275380 4/22 (18%)
LRR_8 626..710 CDD:290566 31/87 (36%)
leucine-rich repeat 628..649 CDD:275380 6/20 (30%)
leucine-rich repeat 652..672 CDD:275380 8/19 (42%)
LRR_8 698..765 CDD:290566 23/68 (34%)
leucine-rich repeat 700..726 CDD:275380 8/25 (32%)
leucine-rich repeat 727..745 CDD:275380 6/17 (35%)
LRR_8 777..839 CDD:290566
leucine-rich repeat 779..802 CDD:275380
leucine-rich repeat 829..852 CDD:275380
CHADLXP_011528235.1 leucine-rich repeat 132..155 CDD:275380 5/33 (15%)
LRR_RI <133..358 CDD:238064 78/304 (26%)
LRR_8 133..214 CDD:290566 27/113 (24%)
leucine-rich repeat 156..179 CDD:275380 10/33 (30%)
leucine-rich repeat 180..203 CDD:275380 6/22 (27%)
leucine-rich repeat 204..227 CDD:275380 10/22 (45%)
LRR_8 228..286 CDD:290566 21/57 (37%)
leucine-rich repeat 228..251 CDD:275380 7/22 (32%)
leucine-rich repeat 252..275 CDD:275380 9/22 (41%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
leucine-rich repeat 300..323 CDD:275380 10/32 (31%)
LRR_8 322..380 CDD:290566 18/104 (17%)
leucine-rich repeat 324..347 CDD:275380 9/59 (15%)
LRR_4 346..>380 CDD:289563 9/43 (21%)
LRRNT 463..497 CDD:214470 6/42 (14%)
leucine-rich repeat 478..494 CDD:275380 2/15 (13%)
LRR_RI 492..671 CDD:238064 49/179 (27%)
leucine-rich repeat 495..518 CDD:275380 5/22 (23%)
LRR_8 518..577 CDD:290566 19/58 (33%)
leucine-rich repeat 519..542 CDD:275380 7/22 (32%)
leucine-rich repeat 543..566 CDD:275380 8/22 (36%)
LRR_8 565..625 CDD:290566 15/60 (25%)
leucine-rich repeat 567..590 CDD:275380 6/22 (27%)
leucine-rich repeat 591..614 CDD:275380 6/23 (26%)
leucine-rich repeat 615..638 CDD:275380 4/22 (18%)
LRR_8 637..698 CDD:290566 22/62 (35%)
leucine-rich repeat 639..662 CDD:275380 7/22 (32%)
leucine-rich repeat 663..687 CDD:275380 8/23 (35%)
LRR_8 686..745 CDD:290566 25/75 (33%)
leucine-rich repeat 688..712 CDD:275380 10/25 (40%)
LRR_4 711..>744 CDD:289563 15/47 (32%)
LRRCT 743..791 CDD:214507 9/31 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121256at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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