DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Tlr3

DIOPT Version :9

Sequence 1:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001344245.1	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	905	Identity:	218/905 - (24%)
Similarity:	366/905 - (40%)	Gaps:	169/905 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 DLPIETFQPLRKLKTLDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLEAQHIADLTKLGWCN 252
            |||       ..:..|:|..|||..|....|....:|.:||...|.|.|||.:....|..|...|
Mouse    49 DLP-------SNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLN 106

  Fly   253 VSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSI 317
            :.||.||::|..||...:.|..|.|..|.|.::.:|.|:..:.|.:|.||.|.|:....||...:
Mouse   107 LQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQL 171

  Fly   318 ARIGTIDLARNR---LKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDI---YQAIINVSHNA 376
            ..:..:.||:|:   |:..|.: |...:.:..|||:.|.:.:.....|:.|   :..::|.:...
Mouse   172 ENLQELLLAKNKILALRSEELE-FLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLN 235

  Fly   377 LELIETAAFE-NCVNITVLDLSHNRLANFSRRSFD--ETTFATYFQLSYNNLTNLAQIPIQNMTG 438
            ..|.|...:| :..:|..|.|::|:|...|..:|.  :.|..|...||||||.::.......:..
Mouse   236 PHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPS 300

  Fly   439 LKVLNASYNSITEIPKNCFPKLYELHTIDV------------SHNNISSIFNGVFQTLFSLRSID 491
            |:.|:..||:|..:....|..|..|..:.:            ||.||...   .||.|..|..::
Mouse   301 LRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDF---SFQWLKYLEYLN 362

  Fly   492 LSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKLFQLP-ISL 555
            :..|::...||:||..|.:|..:.||..            .|||:.  |.|.....|...| ::|
Mouse   363 MDDNNIPSTKSNTFTGLVSLKYLSLSKT------------FTSLQT--LTNETFVSLAHSPLLTL 413

  Fly   556 NELYFSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKD 620
            |   .:.|.::.|.:||:..:..|..|||..|::...|:|:.:.||..:..:.|..|
Mouse   414 N---LTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYN-------- 467

  Fly   621 AVAVMSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVK--DISKRAFEGLLQLLTLNLSS 683
                    :||.|..        |:|..:|.|..|.|....:|  |||...|..|..|..|:||:
Mouse   468 --------KYLQLST--------SSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSN 516

  Fly   684 NGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKTN-----GVLDDLLSLETLDLSHNRISFVTKK 743
            |.|..:..|:..||.:|..||...|:|.:|..:.|     ..|..|..|..|:|..|.:..:...
Mouse   517 NNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVG 581

  Fly   744 TFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDM 808
            .|.:    .:.|:::||..                        |.:|.|...:..:.|||:||::
Mouse   582 VFKN----LFELKSINLGL------------------------NNLNKLEPFIFDDQTSLRSLNL 618

  Fly   809 SYNELSNLKSEEHIFDLP-QNLSWLDLSHNKIYHLPFANLVKVKS--LKYVDLTNNSLEDVPASI 870
            ..|.::::  |:.:|..| |||:.||:..|     ||....:..|  :.:::.|:.::.::
Mouse   619 QKNLITSV--EKDVFGPPFQNLNSLDMRFN-----PFDCTCESISWFVNWINQTHTNISEL---- 672

  Fly   871 VGSMRNGSQVLLAGNPLHCGCNARPLKYFMLQQTIAGEDLKSIYCGTPALIKDKQLISLDDEYLH 935
                   |...|...|.|  ....|||.|...........:.::..:.:::....|:.|   .:|
Mouse   673 -------STHYLCNTPHH--YYGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVL---LIH 725

  Fly   936 CAEDEQEMYKGIDYEQLTDVRFREVKTNKAGMLTLCWYVSGFSDVSDFHVYIRSSSNDVLHQSDY 1000
            ........|..:...::  :.|:|:.|.              ::..::..||..:..|    .|:
Mouse   726 IEGWRISFYWNVSVHRI--LGFKEIDTQ--------------AEQFEYTAYIIHAHKD----RDW 770

  Fly  1001 AYNNRTAQIPVEELSTLGEEKLRGAEICIVSRDSDGNTRKWFSGQCQQLPSLKRPRTFFF 1060
            .:         |..|.: ||:.:..:.|:..||.:...    .|....:.|:||.|...|
Mouse   771 VW---------EHFSPM-EEQDQSLKFCLEERDFEAGV----LGLEAIVNSIKRSRKIIF 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380	3/10 (30%)
		LRR_8	198..258	CDD:290566	20/59 (34%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		LRR_RI	201..545	CDD:238064	101/364 (28%)
		leucine-rich repeat	224..271	CDD:275380	18/46 (39%)
		LRR_8	245..306	CDD:290566	22/60 (37%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		LRR_8	296..354	CDD:290566	18/60 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/22 (36%)
		LRR_8	322..401	CDD:290566	20/85 (24%)
		leucine-rich repeat	322..343	CDD:275380	6/23 (26%)
		leucine-rich repeat	344..367	CDD:275380	6/25 (24%)
		leucine-rich repeat	371..390	CDD:275380	4/19 (21%)
		leucine-rich repeat	391..414	CDD:275380	7/24 (29%)
		leucine-rich repeat	416..438	CDD:275380	7/21 (33%)
		LRR_8	437..495	CDD:290566	16/69 (23%)
		leucine-rich repeat	439..462	CDD:275380	7/22 (32%)
		leucine-rich repeat	463..486	CDD:275380	8/34 (24%)
		LRR_RI	486..738	CDD:238064	71/259 (27%)
		LRR_8	486..545	CDD:290566	15/58 (26%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		leucine-rich repeat	535..554	CDD:275380	5/19 (26%)
		LRR_8	554..614	CDD:290566	17/59 (29%)
		leucine-rich repeat	555..578	CDD:275380	6/22 (27%)
		leucine-rich repeat	579..603	CDD:275380	9/23 (39%)
		leucine-rich repeat	604..627	CDD:275380	2/22 (9%)
		LRR_8	626..710	CDD:290566	28/85 (33%)
		leucine-rich repeat	628..649	CDD:275380	5/20 (25%)
		leucine-rich repeat	652..672	CDD:275380	8/21 (38%)
		LRR_8	698..765	CDD:290566	17/71 (24%)
		leucine-rich repeat	700..726	CDD:275380	9/30 (30%)
		leucine-rich repeat	727..745	CDD:275380	4/17 (24%)
		LRR_8	777..839	CDD:290566	18/62 (29%)
		leucine-rich repeat	779..802	CDD:275380	3/22 (14%)
		leucine-rich repeat	829..852	CDD:275380	6/22 (27%)
Tlr3	NP_001344245.1	leucine-rich repeat	37..53	CDD:275380	3/10 (30%)
		LRR 1	53..74		7/20 (35%)
		leucine-rich repeat	54..77	CDD:275380	7/22 (32%)
		PLN00113	70..>543	CDD:215061	142/517 (27%)
		LRR 2	77..98		8/20 (40%)
		leucine-rich repeat	78..101	CDD:275380	9/22 (41%)
		LRR 3	101..122		9/20 (45%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		LRR 5	149..170		8/20 (40%)
		leucine-rich repeat	150..199	CDD:275380	14/49 (29%)
		LRR 6	173..196		6/23 (26%)
		LRR 7	199..220		5/20 (25%)
		leucine-rich repeat	200..250	CDD:275380	10/49 (20%)
		LRR 8	250..271		7/20 (35%)
		leucine-rich repeat	251..276	CDD:275380	7/24 (29%)
		LRR 9	276..297		7/20 (35%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR 10	300..321		6/20 (30%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR 11	324..345		2/20 (10%)
		leucine-rich repeat	325..381	CDD:275380	15/58 (26%)
		LRR 12	357..378		6/20 (30%)
		LRR 13	381..401		8/33 (24%)
		leucine-rich repeat	382..433	CDD:275380	16/67 (24%)
		LRR 14	409..430		7/23 (30%)
		LRR 15	433..454		7/20 (35%)
		leucine-rich repeat	434..458	CDD:275380	9/23 (39%)
		LRR 16	458..479		7/44 (16%)
		leucine-rich repeat	459..482	CDD:275380	7/46 (15%)
		LRR 17	482..502		7/19 (37%)
		leucine-rich repeat	483..508	CDD:275380	9/24 (38%)
		PPP1R42	503..>649	CDD:411060	47/180 (26%)
		LRR 18	508..529		7/20 (35%)
		leucine-rich repeat	509..532	CDD:275380	9/22 (41%)
		LRR 19	532..553		7/20 (35%)
		leucine-rich repeat	533..564	CDD:275380	9/30 (30%)
		LRR 20	564..585		5/20 (25%)
		leucine-rich repeat	565..586	CDD:275380	5/24 (21%)
		LRR 21	588..609		6/44 (14%)
		leucine-rich repeat	589..610	CDD:275378	6/44 (14%)
		LRR 22	612..633		7/22 (32%)
		leucine-rich repeat	613..637	CDD:275380	7/25 (28%)
		LRRCT	646..698	CDD:214507	13/69 (19%)
		Tlr3_TMD	699..731	CDD:407816	3/34 (9%)
		TIR	756..901	CDD:214587	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I4143
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960