back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conv and Chadl

DIOPT Version :10

Sequence 1:	NP_610948.2	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_001419062.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	737	Species:	Rattus norvegicus

Alignment Length:	797	Identity:	185/797 - (23%)
Similarity:	308/797 - (38%)	Gaps:	175/797 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 NSLGIIRVTNGNLSDLPIETFQPLRKLKTLDLHGNQLENLKRNQFKNLRELEVLDISHNQIKKLE 238
            ||...:...:.||:::| :|...|  .:.|||.||.|:.:....|::|..|..||:.|.|::
  Rat    35 NSRRHVTCQHQNLTEVP-DTIPEL--TQRLDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQVE--- 93

  Fly   239 AQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANSFRGMRFLRRLFLSD 303
                                 :::.|.|.....|..|:|:.|:::.|...:..|:..||||.|..
  Rat    94 ---------------------QVAEGAFRGLGRLLFLNLASNRLSSLPQEALDGLGSLRRLELER 137

  Fly   304 NVLTDIGRGTFGSIARIGTIDLARNR---LKKIEFQMFTQMNYVELLDLAENNITKIEKNSFKDI 365
            |:|.::..||||::..:.|::||.|.   |..:.||...:..:::|
  Rat   138 NMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQL------------------- 183

  Fly   366 YQAIINVSHNALELIETAAFENCVNITVLDLSHNRLANFSRRSFDETTFATYFQLSYNNLTNLAQ 430
                   |||||.::...|......:..|.|.||.|......:..:.......:|.:|.||...:
  Rat   184 -------SHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGE 241

  Fly   431 IPIQNMTGLKVLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHN 495
            .....:.||:.|...:.|:..:....|.....|||:|:..|.::::  ...|....||.:.|..|
  Rat   242 EDGLALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTL--PPLQVPGQLRRLRLQGN 304

  Fly   496 SM---------------------------REIKSSTFGTL-PTLLEM--DLSHNELVSVVRGSLA 530
            .:                           |.::..|..|| |:.|..  |.:.:|......|..:
  Rat   305 PLWCACHARPLLEWLVRARVRSDGACRGPRRLRGETLDTLRPSDLRCPGDAAEDEDEDRPAGPRS 369

  Fly   531 KLTSLRQLYLNNNQLEKLFQLP-----ISLNELYFS---HNRLTNIPSGTWPVMNSLIYLDLSHN 587
            ...||.:        |..:..|     :.:.|...|   ...|..:|.| :|  |....|||..|
  Rat   370 PPRSLHE--------EARWATPCPPACVCVGETRHSACDGRGLQAVPRG-FP--NDTQLLDLRRN 423

  Fly   588 QLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVL 652
            .. .::...:|.||..:..|.||:.||::....|:|.:..|.||:|.||.::.|..:|....|.|
  Rat   424 HF-PSVPRAAFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNL 487

  Fly   653 FELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKT 717
            ..|.|..|:...|...|...|.:|.:|:|..|.:..|......|..:||.|.||.|.:|::   :
  Rat   488 GYLYLEHNRFLRIPGAALRALPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHITQV---S 549

  Fly   718 NGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYNLRNLNLSYNLMPILTYDITFGTKKLVRL 782
            .|.|.....||.|.|..|::           :.:|.....                 |...|..|
  Rat   550 PGALGPARELEKLHLDRNQL-----------RQVPTGALE-----------------GLPALKEL 586

  Fly   783 DVSHNQINDLRRGVISNF-TSLQSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFAN 846
            .:|.|....|..|..... .|||.|.::.::|..:.        |:..|.|.
  Rat   587 QLSRNPFRALHDGAFQPVGRSLQQLFLNSSDLEQIS--------PRAFSGLG------------- 630

  Fly   847 LVKVKSLKYVDLTNNSLEDVPASIVGSMRNGSQVL-LAGNPLHCGCNARPLKYFMLQQTIAGEDL 910
                |.|:.:.|..|.|:.:||.:   ..:|.::: |:|||.||.|...|     |.:.:.|.:|
  Rat   631 ----KGLQGLYLQQNQLQSLPAPM---WLSGLELIDLSGNPFHCDCQLLP-----LHRWLTGLNL 683

  Fly   911 K-SIYCGTPALIKDKQL 926
            : ...|.||..::.:::
  Rat   684 RVGATCATPPSVRGQKV 700

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.