Protein Alignment conv and tlr2

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_002933537.2
• Gene: tlr2 / 100485771
• XenbaseID: XB-GENE-481145
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 676
• Identity: 164/676 - (24%)
• Similarity: 267/676 - (39%)
• Gaps: 186/676 - (27%)

  Fly   162 LPKDLFAGQEIANSLGIIRVTNGNLSDLPIETFQPLRKLKTLDLHGNQLENLKRNQFKNLRELEV 226
            ||:|:......:|::.|:..|:          .||..:|:||.|..|.:..:....|:.|..||.
 Frog    48 LPRDVRGLNLSSNAIQIVTETD----------LQPYDQLQTLLLQYNAIHTINDGSFQPLGNLEE 102

  Fly   227 LDISHNQIKKLEAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVLHLSHNQIARLDANS-F 290
            ||:|:|                   |:||     ||...|.....||.|:|..||...|..|| |
 Frog   103 LDLSYN-------------------NLSH-----LSSAWFRNLYNLKHLNLLGNQYLTLGNNSLF 143

  Fly   291 RGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRL-----------KKIEFQMFTQMNYV 344
            ..:..||.|...:...:.|.:..|.|:.|:..:::...:|           |:|...:.| :|..
 Frog   144 ASLSSLRSLQFGNQDFSAIQKLHFESLERLNILEIKAAQLGLYEEGSLAAIKQINHAVLT-VNIQ 207

  Fly   345 ELLDLAENNITKIEKNSFKDI-------YQAIINVSHNALELIETAAFENCVNITVLDLSHNRLA 402
            .|..|..:.|..:.....||:       .:|::.::..:::.:   .|.||:   :.|.|.:||.
 Frog   208 NLRALLNDFIHSVTLLEMKDMQFGDAADVKAMVILNDTSIKYL---VFRNCI---ITDQSASRLL 266

  Fly   403 NFSRRSFDETTFATYFQLSYNNLTNL-----------AQIPIQNMTGLKVLNASYNSITEIPK-N 455
            ..             || :|.|:|:.           ...|:.......|..|..|.: .||| .
 Frog   267 EI-------------FQ-TYRNITDFILDDSTLYGTGTASPVIGDDPFSVTTAIINKL-HIPKFF 316

  Fly   456 CFPKLYELHTIDVSHNNISSIFNGVF-------QTLFSLRSIDLSHNSMRE--IKSSTF-----G 506
            .|..|..::.:..:..||:.|.:.||       ::..||:.:|||.|.:.:  :.||..     |
 Frog   317 LFSDLQGIYKLASNFKNIACIDSKVFLMPCAFSRSFSSLQYLDLSGNLLSDNLLASSACAFEGGG 381

  Fly   507 TLPTLLEMDLSHNELVSVVRGSLAKLTS-LRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPS 570
            ..|.|..:::|.|.|.|:.|  ||::|| |:  ||.|               |..|.|....:.:
 Frog   382 AWPILQTLNVSRNLLTSLRR--LAQITSGLK--YLTN---------------LDVSQNNFGELST 427

  Fly   571 GT--WPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHL 633
            .|  ||  .||.||::|.:|:                     :|....||        |||.|.:
 Frog   428 STCQWP--KSLKYLNISSSQM---------------------SNITCIPP--------TLQILDV 461

  Fly   634 ENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLL--QLLTLNLSSNGIQTLQNDIFVG 696
            .:|.:|....    |:|.|.||.:..|::..:.    ||:.  :|..|::..|.:    ||.:..
 Frog   462 SSNYLTVFTI----KMPNLTELYISNNRLSKLP----EGMYFPRLFMLSIDRNKL----NDFYQS 514

  Fly   697 LPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNR-ISFVTKKTFPSHQYI---PYNLRN 757
                 :||| |..||.||.:.|..   |.|.:.|...|:. |:.|   .:|. .||   |.::|.
 Frog   515 -----DLDL-FPQLTTLDGRDNNY---LCSCQFLSFMHSHTIALV---GWPD-DYICDSPSSVRG 566

  Fly   758 LNL-SYNLMPILTYDITFGTKKLVRL 782
            ..: ..||.|::.:.....|...:.|
 Frog   567 KRIQDANLPPLVCHKTLIVTLSCILL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380	3/12 (25%)
		leucine-rich repeat	176..199	CDD:275380	4/22 (18%)
		PPP1R42	191..359	CDD:455733	46/179 (26%)
		LRR_8	198..258	CDD:404697	16/59 (27%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	224..271	CDD:275380	12/46 (26%)
		leucine-rich repeat	272..295	CDD:275380	10/23 (43%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		leucine-rich repeat	322..343	CDD:275380	4/31 (13%)
		leucine-rich repeat	344..367	CDD:275380	5/29 (17%)
		LRR	346..718	CDD:443914	98/409 (24%)
		leucine-rich repeat	371..390	CDD:275380	3/18 (17%)
		leucine-rich repeat	391..414	CDD:275380	4/22 (18%)
		leucine-rich repeat	416..438	CDD:275380	6/32 (19%)
		leucine-rich repeat	439..462	CDD:275380	8/23 (35%)
		leucine-rich repeat	463..486	CDD:275380	5/29 (17%)
		leucine-rich repeat	487..510	CDD:275380	8/29 (28%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		leucine-rich repeat	535..554	CDD:275380	4/18 (22%)
		leucine-rich repeat	555..578	CDD:275380	6/24 (25%)
		leucine-rich repeat	579..603	CDD:275380	5/23 (22%)
		leucine-rich repeat	604..627	CDD:275380	3/22 (14%)
		leucine-rich repeat	628..649	CDD:275380	5/20 (25%)
		PPP1R42	631..849	CDD:455733	41/159 (26%)
		leucine-rich repeat	652..672	CDD:275380	4/19 (21%)
		leucine-rich repeat	700..726	CDD:275380	10/25 (40%)
		leucine-rich repeat	727..745	CDD:275380	4/18 (22%)
		leucine-rich repeat	779..802	CDD:275380	1/4 (25%)
		leucine-rich repeat	829..852	CDD:275380
tlr2	XP_002933537.2	LRR	<55..>224	CDD:443914	49/203 (24%)
		leucine-rich repeat	55..75	CDD:275378	5/29 (17%)
		LRR_8	75..133	CDD:404697	23/81 (28%)
		leucine-rich repeat	76..99	CDD:275378	7/22 (32%)
		leucine-rich repeat	100..123	CDD:275378	12/46 (26%)
		leucine-rich repeat	124..148	CDD:275378	10/23 (43%)
		leucine-rich repeat	149..162	CDD:275378	3/12 (25%)
		LRR	290..>541	CDD:443914	84/322 (26%)
		leucine-rich repeat	322..352	CDD:275378	5/29 (17%)
		leucine-rich repeat	355..382	CDD:275380	7/26 (27%)
		leucine-rich repeat	386..411	CDD:275380	11/28 (39%)
		leucine-rich repeat	412..435	CDD:275380	8/39 (21%)
		leucine-rich repeat	436..455	CDD:275380	8/47 (17%)
		leucine-rich repeat	456..475	CDD:275380	6/22 (27%)
		leucine-rich repeat	476..497	CDD:275380	6/24 (25%)
		leucine-rich repeat	498..521	CDD:275380	9/32 (28%)
		TIR	634..779	CDD:214587