Protein Alignment conv and LRRC70

DIOPT Version :10

• Sequence 1: NP_610948.2
• Gene: conv / 36588
• FlyBaseID: FBgn0261269
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_852607.3
• Gene: LRRC70 / 100130733
• HGNCID: 35155
• Length: 622
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 125/482 - (25%)
• Similarity: 224/482 - (46%)
• Gaps: 70/482 - (14%)

  Fly   434 QNMTGLKVLNASYNSITEIPKNCFPKLYELHTIDVSHNNISSIFNGVFQTLFSLRSIDLSHNSMR 498
            |..|| :.:|.....::.|||| ||:              |::|            :.|:.|::.
Human    37 QLCTG-RQINCRNLGLSSIPKN-FPE--------------STVF------------LYLTGNNIS 73

  Fly   499 EIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAKLTSLRQLYLNNNQLEKL----FQLPISLNELY 559
            .|..|....|.:|:.:.|.::.::.|...:..:|..|..|:||||.:::|    |:..::|..||
Human    74 YINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLY 138

  Fly   560 FSHNRLTNIPSGTWPVMNSLIYLDLSHNQLGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAV 624
            ..:|:::.:|.|.:..:.|:.||:|..|:| ..|...:|.|::.::.|.|.||.|.:..:.....
Human   139 LQYNQVSFVPRGVFNDLVSVQYLNLQRNRL-TVLGSGTFVGMVALRILDLSNNNILRISESGFQH 202

  Fly   625 MSTLQYLHLENNNITTLERSAFGKLPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTL 689
            :..|..|:|.:||:|.:..:||..|..|..|:|..|.::.|...||:||..|..|.|.::.|:.:
Human   203 LENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNV 267

  Fly   690 QNDIFVGLPSLRNLDLSFNSLTKLDNKTNGVLDDLLSLETLDLSHNRISFVTKKTFPSHQYIPYN 754
            ..|.|.|:.:|::|.||.|.|..|::.|..:|.:|:.|:   |..|||..:...||   :.:..:
Human   268 TRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLK---LDRNRIISIDNDTF---ENMGAS 326

  Fly   755 LRNLNLSYNLMPILTYDITFGTKKLVRLDVSHN------QINDLRRGVIS----------NFTSL 803
            |:.||||:|.:..|...:......|:.|..:.|      ::..||..:.|          |..|:
Human   327 LKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSM 391

  Fly   804 QSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFANLV---KVKS----LKYVDLTNN 861
            :...:.|..::|..:.    .:..:.:|..:....|:|...|.::   ||.:    |:..:..|.
Human   392 RGRALRYINITNCVTS----SINVSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETENI 452

  Fly   862 SL-EDVPASIVGSMRNGSQVLLAGNPL 887
            :. |.:|.|..|..   .|....||||
Human   453 TFWERIPTSPAGRF---FQENAFGNPL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conv	NP_610948.2	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		PPP1R42	191..359	CDD:455733
		LRR_8	198..258	CDD:404697
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	224..271	CDD:275380
		leucine-rich repeat	272..295	CDD:275380
		leucine-rich repeat	296..319	CDD:275380
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		LRR	346..718	CDD:443914	81/287 (28%)
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380
		leucine-rich repeat	416..438	CDD:275380	1/3 (33%)
		leucine-rich repeat	439..462	CDD:275380	7/22 (32%)
		leucine-rich repeat	463..486	CDD:275380	2/22 (9%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		leucine-rich repeat	535..554	CDD:275380	8/22 (36%)
		leucine-rich repeat	555..578	CDD:275380	6/22 (27%)
		leucine-rich repeat	579..603	CDD:275380	8/23 (35%)
		leucine-rich repeat	604..627	CDD:275380	5/22 (23%)
		leucine-rich repeat	628..649	CDD:275380	8/20 (40%)
		PPP1R42	631..849	CDD:455733	62/236 (26%)
		leucine-rich repeat	652..672	CDD:275380	7/19 (37%)
		leucine-rich repeat	700..726	CDD:275380	10/25 (40%)
		leucine-rich repeat	727..745	CDD:275380	5/17 (29%)
		leucine-rich repeat	779..802	CDD:275380	7/38 (18%)
		leucine-rich repeat	829..852	CDD:275380	6/25 (24%)
LRRC70	NP_852607.3	LRRNT	31..59	CDD:396168	8/23 (35%)
		LRR	49..>383	CDD:443914	100/367 (27%)
		LRR 1	61..82		6/32 (19%)
		leucine-rich repeat	65..85	CDD:275380	5/19 (26%)
		LRR 2	85..106		3/20 (15%)
		leucine-rich repeat	86..109	CDD:275380	4/22 (18%)
		LRR 3	109..130		8/20 (40%)
		leucine-rich repeat	110..133	CDD:275380	8/22 (36%)
		LRR 4	133..154		6/20 (30%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	157..178		8/21 (38%)
		leucine-rich repeat	158..181	CDD:275380	8/23 (35%)
		LRR 6	181..202		5/20 (25%)
		leucine-rich repeat	182..205	CDD:275380	5/22 (23%)
		LRR 7	205..226		8/20 (40%)
		leucine-rich repeat	206..229	CDD:275380	9/22 (41%)
		LRR 8	229..250		7/20 (35%)
		leucine-rich repeat	230..253	CDD:275380	9/22 (41%)
		LRR 9	253..274		6/20 (30%)
		leucine-rich repeat	254..277	CDD:275380	7/22 (32%)
		LRR 10	277..298		8/20 (40%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		LRR 11	301..322		8/26 (31%)
		leucine-rich repeat	302..326	CDD:275380	8/29 (28%)
		LRR 12	326..347		7/20 (35%)
		leucine-rich repeat	327..348	CDD:275380	7/20 (35%)