DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8531 and DNAJC11

DIOPT Version :9

Sequence 1:	NP_610945.1	Gene:	CG8531 / 36584	FlyBaseID:	FBgn0033918	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_060668.2	Gene:	DNAJC11 / 55735	HGNCID:	25570	Length:	559	Species:	Homo sapiens

Alignment Length:	545	Identity:	240/545 - (44%)
Similarity:	354/545 - (64%)	Gaps:	15/545 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SDAELD-ENYYTFLNLPRDATAEQINTAYRKQSRMFHPDKHLDPDSKKMAEIMFNRTKRAYEVLS 71
            |:.||| |:||:.||:.|:|::|::..|||:...::|||||.||:.|..||.:||...:||||||
Human     6 SEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLS 70

  Fly    72 DPQQRAIYDSVGEKGLRTEGWEILHRTKTPDEIREEYERLAQAAAERRLQQRTNPRGNITINVNA 136
            |||.|||||..|::||..||||::.|.:||.|||||:|||.:...||||||||||:|.|::.|:|
Human    71 DPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDA 135

  Fly   137 TEIFAPYDD-------SEMPHVEIGSMSIAQSIEAPITRKDMIIMSGNLYSSNGNGSGGFVIAGR 194
            |::|..||:       |..|.:||..|.|:||||||:|..|..|:||:|.:.||||.|....|.|
Human   136 TDLFDRYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALR 200

  Fly   195 RLLN-KGWIELCAGAGN--GFLLGLKGGRTLSQKLTLNGGTNLNFRDQGVIPALFSTLAVQLDKH 256
            |:.: |||.||..|||:  |.|.|||..|.|:.:..:.....|.|..:|:.|.|.:.||..|||:
Human   201 RVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKN 265

  Fly   257 TMGSLTLNAGSQSSMSTQIDHSKETYSLSSSLVIGTPHVYFGLSYTRKMM-ENELKLKLAAKVGT 320
            |:|.|....|.||:|:|.|....:|...:.:|.:|.||.:..:||..|.. :::.::|.:.|.|.
Human   266 TVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGF 330

  Fly   321 FGFMGEYGVEKKVSKYSSVTATVSIGVPSGVILKFKILRSNQSYVFPIHLSDEIVPAAVFYASVT 385
            ||.:.|||.|:|:|::|.:.|.||:|||.||.||.|:.|::|:|.|||||:|:::|:|:|||:|.
Human   331 FGTVVEYGAERKISRHSVLGAAVSVGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAMFYATVG 395

  Fly   386 PVIAWFFIKRTVMDPMEAERKNIEVERTKRQNEQRLSAKRHEASAAVHLMQATYNRIMTEELARN 450
            |::.:|.:.|.::.|....:|..|:|:.:......:..|:.||.:||.|||.:..||:..|.:|.
Human   396 PLVVYFAMHRLIIKPYLRAQKEKELEKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRM 460

  Fly   451 GLIVTRAVYGCTLAGGRQFKPE--QSLDVTVAIQCMVKNGTLQLHDSSKSDLPGFYDPGIGEDKI 513
            |||:..|.|| .....:..|.|  :.:||||.:||:||:..|.|.::||:.|||||||.:||:|.
Human   461 GLIIVNAWYG-KFVNDKSRKSEKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKN 524

  Fly   514 LRIEYTYQNQFEVIHIKDNEALRLP 538
            |::.|.::.....:.:.|:||||:|
Human   525 LKVLYQFRGVLHQVMVLDSEALRIP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8531	NP_610945.1	DnaJ	15..>91	CDD:223560	39/75 (52%)
		DnaJ	15..80	CDD:278647	34/64 (53%)
		DUF3395	409..538	CDD:288708	51/130 (39%)
DNAJC11	NP_060668.2	DnaJ	14..79	CDD:278647	34/64 (53%)
DNAJC11	NP_060668.2	DUF3395	417..549	CDD:288708	51/132 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142055
Domainoid	1	1.000	271	1.000	Domainoid score	I1824
eggNOG	1	0.900	-	-		E2759_KOG0718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14558
Inparanoid	1	1.050	447	1.000	Inparanoid score	I1636
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55406
OrthoDB	1	1.010	-	-		D400850at33208
OrthoFinder	1	1.000	-	-		FOG0003651
OrthoInspector	1	1.000	-	-		oto89565
orthoMCL	1	0.900	-	-		OOG6_103676
Panther	1	1.100	-	-	LDO	PTHR44157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5111
SonicParanoid	1	1.000	-	-		X3531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800