DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and ECM10

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_010884.1	Gene:	ECM10 / 856682	SGDID:	S000000756	Length:	644	Species:	Saccharomyces cerevisiae

Alignment Length:	631	Identity:	384/631 - (60%)
Similarity:	495/631 - (78%)	Gaps:	4/631 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERL 99
            |.|.:....|::|.::..||||||||||||.:|:||||..::||||||:|||||.||||||||||
Yeast    10 AHNILRILTRFQSTKIPDAVIGIDLGTTNSAVAIMEGKVPRIIENAEGSRTTPSVVAFTKDGERL 74

  Fly   100 VGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKVYSPS 164
            ||.|||||:|.||.||.:||||||||||:|.||::||..:.:|:||.|||||||.:.: :.|||:
Yeast    75 VGEPAKRQSVINSENTLFATKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWVEARN-RTYSPA 138

  Fly   165 QIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALA 229
            |||.|||.||||||||||...||||||||||||||:|||||||||||.|||||||:|||||||||
Yeast   139 QIGGFILNKMKETAEAYLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALA 203

  Fly   230 YGMDKTEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDS 294
            ||:||:|.|:|||:||||||||||||:|..|:||||||||||.|||||||.:::..:::.|||::
Yeast   204 YGLDKSEPKVIAVFDLGGGTFDISILDIDNGIFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKET 268

  Fly   295 GIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLI 359
            |||:..|.:|:||::|||||||.||||:..|:||||::|.|||||:|:.:..:|.:||::...||
Yeast   269 GIDLSNDRMAVQRIREAAEKAKIELSSTLSTEINLPFITADAAGPKHIRMPFSRVQLENITAPLI 333

  Fly   360 KRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQ 424
            .||:.|.:|||.||.::.|:|.:|||||||:|||||..||::|||:..|::||||||||:|||:|
Yeast   334 DRTVDPVKKALKDARITASDISDVLLVGGMSRMPKVADTVKKLFGKDASKAVNPDEAVALGAAIQ 398

  Fly   425 GGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQG 489
            ..||:|:||||||||||||||||||||||||:||.||:|||.||||:||||:.|||.||:||.||
Yeast   399 AAVLSGEVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEVKVFQG 463

  Fly   490 EREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQSSGGLS 554
            |||:..||||:|:|||.||||||:|.|||||.||||||||::|||||..:.|:..|.:..:.|||
Yeast   464 ERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITVAGASGLS 528

  Fly   555 KDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLR 619
            ..||:.|:.:||.|...|:.:|..||..|:.:.:.:|||..::||:.:|...:.::||.:|:.||
Yeast   529 DTEIDRMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKEFEGKLDKTDSQRLKDQISSLR 593

  Fly   620 TLLANKETADL---EEVRKATSSLQQSSLKLFELAYKKMSAERESN 662
            .|::..:..|.   ::|.....:|:.||:||||..||........|
Yeast   594 ELVSRSQAGDEVNDDDVGTKIDNLRTSSMKLFEQLYKNSDNPETKN 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	380/615 (62%)
		HSPA9-like_NBD	51..428	CDD:212683	253/376 (67%)
		Syntaphilin	<566..>642	CDD:291936	22/78 (28%)
ECM10	NP_010884.1	dnaK	29..644	CDD:234715	379/612 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344911
Domainoid	1	1.000	775	1.000	Domainoid score	I6
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	799	1.000	Inparanoid score	I59
Isobase	1	0.950	-	0	Normalized mean entropy	S115
OMA	1	1.010	-	-		QHG61239
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm46608
orthoMCL	1	0.900	-	-		OOG6_100423
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1906
TreeFam	1	0.960	-	-
	14	13.710