DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and SSZ1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_011931.2	Gene:	SSZ1 / 856461	SGDID:	S000001106	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	548	Identity:	150/548 - (27%)
Similarity:	255/548 - (46%)	Gaps:	82/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VIGIDLGTTNSCLAVMEGK-QAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            ||||..|.|:|.:|.:..| ...||.|.:|.|..||.:::..:.| ..|..|.:|.:.|..||..
Yeast     5 VIGITFGNTSSSIAYINPKNDVDVIANPDGERAIPSALSYVGEDE-YHGGQALQQLIRNPKNTII 68

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKV-------------YSPSQIGAF 169
            ..:..||..||    |.|::       |.:|| |.....||||             .:..::.:.
Yeast    69 NFRDFIGLPFD----KCDVS-------KCANG-APAVEVDGKVGFVISRGEGKEEKLTVDEVVSR 121

  Fly   170 ILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYG--M 232
            .|.::|..||.|:.:.||.||:|||..|::.|:.|.|.:....||.:::.||||:||.||:.  .
Yeast   122 HLNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQF 186

  Fly   233 DKTEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGID 297
            ...:|..:.|.|.||...|.:::.::.|:|.:.:|..|..|||::.|..:|.:..:||:|....:
Yeast   187 PFEKDVNVVVADFGGIRSDAAVIAVRNGIFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQAN 251

  Fly   298 IRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRT 362
            .||:..::.:||..:...|..||::....|::..|   |.|..: :..:.|.:.|.:...:..:.
Yeast   252 PRKNARSLAKLKANSSITKKTLSNATSATISIDSL---ADGFDY-HASINRMRYELVANKVFAQF 312

  Fly   363 IQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQ-------ELFGRQ-PSRSVNPDEAVAV 419
            .......::.||:...:|..|||.||::..||:.:.::       |:.|.| .:.|.||:|..|.
Yeast   313 SSFVDSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAAS 377

  Fly   420 GAAVQGGVLAGDVTDVLLLDVTPL---------SLGIETLGGVFTRLISRNTTIPTKKSQVFSTA 475
            |||:|..:::....|.|...:.|:         .:|:....|.|..::...|:.|.:|......|
Yeast   378 GAALQARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFPVQKKLTLKQA 442

  Fly   476 S--------DGQTQVEIKV-----------HQGEREMAND------NKL--LGSFTL-VGIPPAP 512
            .        :|...:|.|.           ...|.|.::|      .||  ||:..: :||..|
Yeast   443 KGDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNA- 506

  Fly   513 RGVPQIEVVFDIDANGIVHVSAKDKGTG 540
            .||   |::|:|:.:|.:.|:|:|..||
Yeast   507 NGV---EIIFNINKDGALRVTARDLKTG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	150/548 (27%)
		HSPA9-like_NBD	51..428	CDD:212683	116/397 (29%)
		Syntaphilin	<566..>642	CDD:291936
SSZ1	NP_011931.2	ScSsz1p_like_NBD	4..384	CDD:212674	116/395 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900