Protein Alignment Hsc70-5 and LHS1

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_012850.1
• Gene: LHS1 / 853789
• SGDID: S000001556
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 655
• Identity: 152/655 - (23%)
• Similarity: 260/655 - (39%)
• Gaps: 125/655 - (19%)

  Fly    53 AVIGIDLGTTNSCLAVMEGKQA--KVIENAEGARTTPSHVA------FTKDG----ERLVGMPAK 105
            ||:|:|.|..| ..|::...||  :::...|..|...|.::      :.||.    ||:.|....
Yeast    21 AVLGVDYGQQN-IKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVG 84

  Fly   106 RQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSS--------TDGKVYS 162
            ..|.....||....|.|:|:..:|     :.|...|.  |...|...||:        .|...|.
Yeast    85 SLATRFPQNTLLHLKPLLGKSLED-----ETTVTLYS--KQHPGLEMVSTNRSTIAFLVDNVEYP 142

  Fly   163 PSQIGAFILMKMKETAEAYLNTP-------VKNAVVTVPAYFNDSQRQATKDAGQI-AGLNVLRV 219
            ..::.|..:.::...|.:.|...       |.....|:|.:|:..||:|..||..| .|:....:
Yeast   143 LEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYL 207

  Fly   220 INEPTAAALAYGMDKT-----EDKIIAVYDLGGGTFDISILEI-------QKGVFEVKSTNGDTL 272
            ::|..:.|:.:.:.:.     |.:...|||:|.|:...|:..|       |....|.:....:..
Yeast   208 VSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPH 272

  Fly   273 LGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI-----AMQRLKEAAEKAKCELSSSQQTDINLPYL 332
            |||..|...|.:.:..:| .::...||.|.:     |:.::.:||||||..||::.:..||:..|
Yeast   273 LGGAKFTMDIGSLIENKF-LETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESL 336

  Fly   333 TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKS---------EIGEVLLVGG 388
            ..|.    .....:||.:.|..:.|.:...::|    ::|| |:|.         ||..|:|.||
Yeast   337 INDI----DFRTSITRQEFEEFIADSLLDIVKP----INDA-VTKQFGGYGTNLPEINGVILAGG 392

  Fly   389 MTRMPKVQSTVQELFGRQP-SRSVNPDEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGI----- 447
            .:|:|.||..:.:|...:. .|:||.||: ||...|..|:...:......|:|...|:..
Yeast   393 SSRIPIVQDQLIKLVSEEKVLRNVNADES-AVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKL 456

  Fly   448 ---ETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQG----EREMANDNKLLGSFTL 505
               ..|..|||    |.:..|.|.|.:.:|.........|.:.:.    |....|...:..|::
Yeast   457 SNESELYDVFT----RGSAYPNKTSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYS- 516

  Fly   506 VGIPPAPRGVPQIEVVFDIDANGIVHV--------SAKDKGTGKEQQIVIQSSG---GLSKDEIE 559
              ......|| ...:.||:.::.:..:        |..|.|..|:    |::.|   ..:.:::|
Yeast   517 --SDKCSSGV-AYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQ----IKNKGSRLAFTSEDVE 574

  Fly   560 NMIKKA---------EEYATADKQKRELI---EIVNQGESIVHDTETKM--EEFKSQLPAEECEK 610
              ||:.         |.....|||.:|..   |.:|..||.::|....:  :|.....|..:.|:
Yeast   575 --IKRLSPSERSRLHEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGPKSQVEE 637

  Fly   611 LKKEI 615
            |.:.:
Yeast   638 LSEMV 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	152/655 (23%)
		HSPA9-like_NBD	51..428	CDD:212683	109/429 (25%)
		Syntaphilin	<566..>642	CDD:291936	14/55 (25%)
LHS1	NP_012850.1	HYOU1-like_NBD	23..430	CDD:212672	106/425 (25%)
		Smc	<581..737	CDD:224117	14/62 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900