Protein Alignment Hsc70-5 and KAR2

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_012500.3
• Gene: KAR2 / 853418
• SGDID: S000003571
• Length: 682
• Species: Saccharomyces cerevisiae
• Alignment Length: 651
• Identity: 321/651 - (49%)
• Similarity: 426/651 - (65%)
• Gaps: 45/651 - (6%)

  Fly    52 GAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            |.|||||||||.||:|||:..:.:::.|.:|.|.|||:|||| |.|||:|..||.|...|..||.
Yeast    50 GTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFT-DDERLIGDAAKNQVAANPQNTI 113

  Fly   117 YATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG--KVYSPSQIGAFILMKMKETAE 179
            :..|||||.:::|..|:|||.:|.:.||......|...|..|  ||::|.:|...||.|||:.||
Yeast   114 FDIKRLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAE 178

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-DKIIAVY 243
            .||.|.|.:|||||||||||:|||||||||.||||||||::|||||||:|||:||:: :..|.||
Yeast   179 DYLGTKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDKEHQIIVY 243

  Fly   244 DLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRL 308
            ||||||||:|:|.|:.|||||::|:|||.|||||||..||..|:..|||..|||:..:|.|:.:|
Yeast   244 DLGGGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKL 308

  Fly   309 KEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDA 373
            |..|||||..|||...|.|.:... :|..   .::..|||:|.|.|..||.|:|::|.:|.|.|:
Yeast   309 KREAEKAKRALSSQMSTRIEIDSF-VDGI---DLSETLTRAKFEELNLDLFKKTLKPVEKVLQDS 369

  Fly   374 EVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD--VTDV 435
            .:.|.::.:::||||.||:||||..::..| |::.|:.:|||||||.|||||.|||:|:  |.|:
Yeast   370 GLEKKDVDDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDI 434

  Fly   436 LLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKLL 500
            :||||..|:|||||.|||.|.||.|||.|||||||:||||.|.|..|.|||::|||.|:.||.||
Yeast   435 VLLDVNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLL 499

  Fly   501 GSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENMIKK 564
            |.|.|.||||||||||||||.|.:|||||:.|||.||||||.:.|.| ...|.|:::||:.|:::
Yeast   500 GKFELTGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEE 564

  Fly   565 AEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTLL------- 622
            ||::|:.|...:..:|..|:.|:..|       ..|:|:..:..|||::|  |..|||
Yeast   565 AEKFASEDASIKAKVESRNKLENYAH-------SLKNQVNGDLGEKLEEE--DKETLLDAANDVL 620

  Fly   623 ----ANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKE 683
                .|.|||..|:..:...||.:.:..:....|             |.:|.|.::|...|.:.:
Yeast   621 EWLDDNFETAIAEDFDEKFESLSKVAYPITSKLY-------------GGADGSGAADYDDEDEDD 672

  Fly   684 E 684
            :
Yeast   673 D 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	316/631 (50%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	314/615 (51%)