DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and ERD2

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_176036.1	Gene:	ERD2 / 842094	AraportID:	AT1G56410	Length:	617	Species:	Arabidopsis thaliana

Alignment Length:	610	Identity:	298/610 - (48%)
Similarity:	414/610 - (67%)	Gaps:	22/610 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTN 111
            :|:.:|..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|
plant     2 AGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMN 65

  Fly   112 SANTFYATKRLIGRRFDDPEVKKDITNLSYKVV--KASNGDAWVS-STDGKVYSPSQIGAFILMK 173
            ..||.:..||||||||.|..|:.|:....:||.  :|.....:|: ..:.|.::..:|.:.:|:|
plant    66 PVNTVFDAKRLIGRRFSDASVQSDMKFWPFKVTPGQADKPMIFVNYKGEEKQFAAEEISSMVLIK 130

  Fly   174 MKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDK 238
            |:|.|||||.:.:|||||||||||||||||||||||.||||||||:||||||||:|||:||....
plant   131 MREIAEAYLGSSIKNAVVTVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKKATS 195

  Fly   239 I----IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIR 299
            :    :.::||||||||:|:|.|::|:||||:|.|||.||||||||.:||..|.|||:.:..||.
plant   196 VGIKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDIS 260

  Fly   300 KDNIAMQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRT 362
            .|..|::||:.|.|:||..|||:.||.:.:..|  .:|...|      :||:|.|.:..||.::.
plant   261 GDARALRRLRTACERAKRTLSSTAQTTVEVDSLFEGIDFYSP------ITRAKFEEMNMDLFRKC 319

  Fly   363 IQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGG 426
            ::|..|.|.|:::.||.:.:|:||||.||:||||..:|:.| |::..:|:|||||||.|||||..
plant   320 MEPVMKCLRDSKMDKSMVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAA 384

  Fly   427 VLAGD----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVH 487
            :|:|:    |.|:||||||||||||||:|||.|.||.||||||.||.|.|:|..|.|..|.|:|:
plant   385 ILSGEGNEKVQDLLLLDVTPLSLGIETIGGVMTTLIQRNTTIPAKKEQEFTTTVDNQPDVLIQVY 449

  Fly   488 QGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSG 551
            :|||....||.:||.|.|.||||||||:||..|.||||:|||::|||:||.|||:.:|.| ...|
plant   450 EGERARTIDNNILGQFVLSGIPPAPRGIPQFTVCFDIDSNGILNVSAEDKATGKKNKITITNDKG 514

  Fly   552 GLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIA 616
            .||||:||.|:::||:|.:.|::.::.:|..|..|:..::....:.:...:|||.:.:|.:..|.
plant   515 RLSKDDIEKMVQEAEKYKSEDEEHKKKVEAKNGLENYAYNVGNTLRDMGEKLPAADKKKFEDSIE 579

  Fly   617 DLRTLLANKETADLEEVRKATSSLQ 641
            ::...|.:.:.|:.:|.......|:
plant   580 EVIQWLDDNQLAEADEFEHKMKELE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	297/606 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	196/386 (51%)
		Syntaphilin	<566..>642	CDD:291936	15/76 (20%)
ERD2	NP_176036.1	PTZ00009	5..617	CDD:240227	297/607 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820