DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and HSP70T-2

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_180771.1	Gene:	HSP70T-2 / 817771	AraportID:	AT2G32120	Length:	563	Species:	Arabidopsis thaliana

Alignment Length:	547	Identity:	161/547 - (29%)
Similarity:	270/547 - (49%)	Gaps:	83/547 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SGEVKGA--------VIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMP 103
            :||.|.:        .:|||:||:...:||..|.|..::.|....:...|.|.|..:      :|
plant    15 TGEEKSSSSPSLPEIALGIDIGTSQCSIAVWNGSQVHILRNTRNQKLIKSFVTFKDE------VP 73

  Fly   104 A---------KRQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKV----------VKASNG 149
            |         :::.:|.:|  .:..|||:||...||.|... .||.:.|          :.|...
plant    74 AGGVSNQLAHEQEMLTGAA--IFNMKRLVGRVDTDPVVHAS-KNLPFLVQTLDIGVRPFIAALVN 135

  Fly   150 DAWVSSTDGKVYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL 214
            :||.|:|      |.::.|..|::::..|||.|..||:|.|:|||..|:..|....:.|..:|||
plant   136 NAWRSTT------PEEVLAIFLVELRLMAEAQLKRPVRNVVLTVPVSFSRFQLTRFERACAMAGL 194

  Fly   215 NVLRVINEPTAAALAY----------GMDKTEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNG 269
            :|||::.||||.||.|          .|....:::..::::|.|..|:::.....||.::|:..|
plant   195 HVLRLMPEPTAIALLYAQQQQMTTHDNMGSGSERLAVIFNMGAGYCDVAVTATAGGVSQIKALAG 259

  Fly   270 DTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTM 334
            .. :||||...:.:..:....::.||:           |:.||:.|...|:..:...|.     :
plant   260 SP-IGGEDILQNTIRHIAPPNEEASGL-----------LRVAAQDAIHRLTDQENVQIE-----V 307

  Fly   335 DAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQK----ALSDAEVSKSEIGEVLLVGGMTRMPKV 395
            |......::..|.|.:.|    ::.::..:.|::    .|.||.|:..:|.::::|||.:.:|||
plant   308 DLGNGNKISKVLDRLEFE----EVNQKVFEECERLVVQCLRDARVNGGDIDDLIMVGGCSYIPKV 368

  Fly   396 QSTVQELFGR-QPSRSVNPDEAVAVGAAVQGGVLAG-----DVTDVLLLDVTPLSLGIETLGGVF 454
            ::.::.:..: :..:.|||.||...|||::|.|.:|     ...|:|.:..|||::|:...|..|
plant   369 RTIIKNVCKKDEIYKGVNPLEAAVRGAALEGAVTSGIHDPFGSLDLLTIQATPLAVGVRANGNKF 433

  Fly   455 TRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIE 519
            ..:|.|||.:|.:|...|:|..|.|.:..|.:::||.|...:|.|||.|.||||||||:|||:|.
plant   434 IPVIPRNTMVPARKDLFFTTVQDNQKEALIIIYEGEGETVEENHLLGYFKLVGIPPAPKGVPEIN 498

  Fly   520 VVFDIDANGIVHVSAKDKGTGKEQQIV 546
            |..||||:..:.|.|.....|....:|
plant   499 VCMDIDASNALRVFAAVLMPGSSSPVV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	159/543 (29%)
		HSPA9-like_NBD	51..428	CDD:212683	109/418 (26%)
		Syntaphilin	<566..>642	CDD:291936
HSP70T-2	NP_180771.1	HSP70_NBD	31..400	CDD:212667	107/404 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820