Protein Alignment Hsc70-5 and Hspa12a

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_006527440.1
• Gene: Hspa12a / 73442
• MGIID: 1920692
• Length: 695
• Species: Mus musculus
• Alignment Length: 685
• Identity: 153/685 - (22%)
• Similarity: 248/685 - (36%)
• Gaps: 214/685 - (31%)

  Fly    54 VIGIDLGTTNSCLAVMEGKQAK---VIENAEGA------RTTPSHVAFTKDGERLVGMPAKRQAV 109
            |:.||.|||:|..|....|:.:   |:...||.      :.||:.:..|.:        .|..:.
Mouse    78 VVAIDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPE--------RKFHSF 134

  Fly   110 TNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAW----VSSTDGKVYSPSQIGAFI 170
            ..:|..||       ...|..|.|:.:....:|:...:.||..    :::.:||.....:|.|:.
Mouse   135 GYAARDFY-------HDLDPSEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFAYA 192

  Fly   171 LMKMKETA---------EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL------NVLRVI 220
            |...||.|         ..:.|:.|: .|:||||.:....:|..::|...|||      ..|.:.
Mouse   193 LQYFKEQALKELSDQAGSDFENSDVR-WVITVPAIWKQPAKQFMREAAYQAGLASPENSEQLIIA 256

  Fly   221 NEPTAAAL--------------------AYGMDKT------------------------------ 235
            .||.||::                    .|....|
Mouse   257 LEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRTFLVENVIGEI 321

  Fly   236 ------EDKIIAVYDLGGGTFDISILEIQ------KGVFEVKSTNG-----------DTLL---G 274
                  .||.:.| |.||||.|:::.:|:      |.::  |:|.|           :.||   .
Mouse   322 WSELEEGDKYVVV-DSGGGTVDLTVHQIRLPEGHLKELY--KATGGPYGSLGVDYEFEKLLCKIF 383

  Fly   275 GEDFDNHIVNFLVAEFK---KDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMD- 335
            ||||        :.:||   ..:.:|:.   ||.:..|.||...:     :...:|.||:..:|
Mouse   384 GEDF--------IEQFKIKRPAAWVDLM---IAFESRKRAAAPDR-----TNPLNITLPFSFIDY 432

  Fly   336 -----AAGPQHMNLKLTRSKLE--------------SLVGDLIKRTIQPCQKALSDAEVSKSEIG 381
                 ....:|   .|.:|.::              ..:..|.|.||....:.|.|. ..|.|:.
Mouse   433 YKKFRGHSVEH---ALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDL-FQKPEVS 493

  Fly   382 EV---LLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAV-QGGVLAGDVTDVLLLDVTP 442
            .|   .||||....|.:|..||..|| ...|.:.|.:   ||..: :|.||.|....|:.:..:|
Mouse   494 TVKFLFLVGGFAEAPLLQQAVQTAFG-DKCRIIIPQD---VGLTILKGAVLFGLDPAVIKVRRSP 554

  Fly   443 LSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQ---TQVEIKVHQGEREMANDNKLLGSFT 504
            |:.|:    ||..|.:....  |.:|..|    .||.   |.|..|....::.:|....:..|:|
Mouse   555 LTYGV----GVLNRYVEGKH--PPEKLLV----KDGTRWCTDVFDKFISADQSVALGELVKRSYT 609

  Fly   505 LVGIPPAPRGVPQIEVVFDIDANGIVHVS-AKDKGTGK--EQQIVIQSSGGLSKDEIENMIKKAE 566
                |..|   .|:.::.:|.::...:|| ..|.|..|  ..::.:..|||
Mouse   610 ----PAKP---SQLVIIINIYSSEHDNVSFITDPGVKKCGTLRLDLTGSGG-------------- 653

  Fly   567 EYATADKQKRELIEIVNQGESIVHDTETKMEEFKS 601
               ||...:||:..|:..|::.:..|...:...||
Mouse   654 ---TAVPARREIQTIMQFGDTEIKATAVDITTSKS 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	153/685 (22%)
		HSPA9-like_NBD	51..428	CDD:212683	111/504 (22%)
		Syntaphilin	<566..>642	CDD:291936	9/36 (25%)
Hspa12a	XP_006527440.1	HSPA12A_like_NBD	77..543	CDD:212685	113/507 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900