DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and hspa8

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	647	Identity:	317/647 - (48%)
Similarity:	424/647 - (65%)	Gaps:	31/647 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            ||..:|||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Zfish     3 KGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKET 177
            .:..||||||||||..|:.|:.:..:.|:. .|....|.   ..:.|.:.|.:|.:.:|.||||.
Zfish    67 VFDAKRLIGRRFDDGVVQSDMKHWPFNVIN-DNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEI 130

  Fly   178 AEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKII 240
            |||||...|.|||:||||||||||||||||||.|:||||||:||||||||:|||:||.  .::.:
Zfish   131 AEAYLGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195

  Fly   241 AVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAM 305
            .::||||||||:|||.|:.|:||||||.|||.||||||||.:||..:.|||:....||..:..|:
Zfish   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRAV 260

  Fly   306 QRLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQK 368
            :||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|:.|.:|
Zfish   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGID------FYTSITRARFEELNADLFRGTLDPVEK 319

  Fly   369 ALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD- 431
            ||.||::.|::|.:::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|:||
Zfish   320 ALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDK 384

  Fly   432 ---VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREM 493
               |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|..|.|:|::|||.|
Zfish   385 SENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAM 449

  Fly   494 ANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDE 557
            ..||.|||.|.|.||||||||||||||.||||||||::|||.||.||||.:|.| ...|.|||::
Zfish   450 TKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKED 514

  Fly   558 IENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLRT 620
            ||.|:::||:|...|..:|:.:...|..||...:.::.:|:  .|.::..|:.:|:..:..::..
Zfish   515 IERMVQEAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDKQKILDKCNEVIG 579

  Fly   621 LLANKETADLEEVRKATSSLQQSS----LKLFELAYKKMSAERESN----AGAGSSDSSSSS 674
            .|...:||:.||.......|::..    .||::.|........|..    .|||::....||
Zfish   580 WLDKNQTAEREEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPEGMPGGFPGAGAAPGGGSS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	313/637 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	197/384 (51%)
		Syntaphilin	<566..>642	CDD:291936	17/77 (22%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	310/618 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		200/390 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910