DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and AgaP_AGAP004583

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_001688624.2	Gene:	AgaP_AGAP004583 / 5667608	VectorBaseID:	AGAP004583	Length:	420	Species:	Anopheles gambiae

Alignment Length:	423	Identity:	229/423 - (54%)
Similarity:	300/423 - (70%)	Gaps:	15/423 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            :.||||||||.||:.|.:..:.::|.|.:|.|||||:|||: |.|||:|..||.|...|..||.:
Mosquito     3 SAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFS-DTERLIGDAAKNQVAMNPTNTVF 66

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG--KVYSPSQIGAFILMKMKETAEA 180
            ..|||||||:|||:::.||.:..:|||.............|  |.::|.::.:.:|.||||||||
Mosquito    67 DAKRLIGRRYDDPKIQADIKHWPFKVVNDCGKPKIQVEFKGERKTFAPEEVSSMVLTKMKETAEA 131

  Fly   181 YLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIAVY 243
            ||...|||||:||||||||||||||||||.||||||:|:||||||||||||:||.  .::.:.::
Mosquito   132 YLGHSVKNAVITVPAYFNDSQRQATKDAGAIAGLNVMRIINEPTAAALAYGLDKNLKGERNVLIF 196

  Fly   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQR 307
            ||||||||:|||.|.:| :|||::|.|||.||||||||.:|...|.|||:....|:.|:..|::|
Mosquito   197 DLGGGTFDVSILTIDEGSLFEVRATAGDTHLGGEDFDNRMVGHFVEEFKRKFKKDVSKNARALRR 261

  Fly   308 LKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSD 372
            |:.|.|:||..||||.:..|.:..| ||  |..:.. |::|::.|.|..||.:.|:||.:|||||
Mosquito   262 LRTACERAKRTLSSSTEATIEIDAL-MD--GIDYYT-KISRARFEELCSDLFRSTLQPVEKALSD 322

  Fly   373 AEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD----V 432
            |::.||.|.:::||||.||:|||||.:|..| |:..:.|:|||||||.|||||..:|:||    :
Mosquito   323 AKMDKSSIHDIVLVGGSTRIPKVQSLLQNFFCGKSLNLSINPDEAVAYGAAVQAAILSGDKDEKI 387

  Fly   433 TDVLLLDVTPLSLGIETLGGVFTRLISRNTTIP 465
            .||||:||.||||||||.|||.|:||.||:.||
Mosquito   388 QDVLLVDVAPLSLGIETAGGVMTKLIERNSRIP 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	229/423 (54%)
		HSPA9-like_NBD	51..428	CDD:212683	202/380 (53%)
		Syntaphilin	<566..>642	CDD:291936
AgaP_AGAP004583	XP_001688624.2	PRK13930	1..373	CDD:237564	198/374 (53%)
AgaP_AGAP004583	XP_001688624.2	HSPA1-2_6-8-like_NBD	4..380	CDD:212675	202/380 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820