DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and hspa13

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001082948.1	Gene:	hspa13 / 560481	ZFINID:	ZDB-GENE-070410-58	Length:	438	Species:	Danio rerio

Alignment Length:	392	Identity:	146/392 - (37%)
Similarity:	231/392 - (58%)	Gaps:	17/392 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAVME--GKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSA 113
            |..|||:|||||...:.|.:  ..:.::||:.:|.::.||.|:||..|. ..|...:..:..|..
Zfish    30 KPRVIGLDLGTTFCSVGVFQPGTGEIEIIEDDKGRKSIPSVVSFTLTGV-FAGHEGQELSDVNPQ 93

  Fly   114 NTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNG--DAWVSSTDGKVYSPSQIGAFILMKMKE 176
            ||.|..||.||:.||:..::|:.....:||: .:||  |..|::......:|..||:.:|:||::
Zfish    94 NTIYDAKRFIGKIFDEETLEKESARYPFKVI-FNNGSADFLVNTNSTFTVTPEFIGSRLLLKMRK 157

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDKIIA 241
            .||..|..||:.||::|||.|::.||..|..|..:|||:||||||||||||:|||:.|.|...:.
Zfish   158 MAEKQLGVPVEKAVISVPAEFDERQRNYTIRAANLAGLDVLRVINEPTAAAMAYGLHKAEVFNVL 222

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGI--DIRKDNIA 304
            |.||||||.|:|:|..|.|:|..::..|:..|||:||...::.:.....::..|:  .:::|
Zfish   223 VVDLGGGTLDVSLLNKQGGMFLTRAMAGNNQLGGQDFTQRLLQYTTERVRQQYGVPPTLKED--- 284

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLP-YLTM-DAAGPQHMNL----KLTRSKLESLVGDLIKRTI 363
            :..|::|.|.||..|:......:.:| ||.| .|:|.|...:    ||||...|.|..||.::.:
Zfish   285 IHLLRQAVEAAKLNLTQEPHVHLRVPLYLQMTGASGAQEEKVLFEEKLTRETFEELNADLFQKIL 349

  Fly   364 QPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL 428
            .|.:..|.:..:.|.|:.|::||||.||:|:::..:.:.||::|:.||:||.||..|.|:|.|::
Zfish   350 APIETVLVEGHLDKQEVDEIVLVGGSTRIPRIRQLISQYFGKEPNTSVDPDLAVVTGVAIQAGIM 414

  Fly   429 AG 430
            .|
Zfish   415 GG 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	146/392 (37%)
		HSPA9-like_NBD	51..428	CDD:212683	145/388 (37%)
		Syntaphilin	<566..>642	CDD:291936
hspa13	NP_001082948.1	HSPA13-like_NBD	23..430	CDD:212679	146/392 (37%)
hspa13	NP_001082948.1	PRK13930	32..409	CDD:237564	141/381 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910