DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and hsph1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_001919957.2	Gene:	hsph1 / 557824	ZFINID:	ZDB-GENE-120410-4	Length:	901	Species:	Danio rerio

Alignment Length:	742	Identity:	208/742 - (28%)
Similarity:	330/742 - (44%)	Gaps:	131/742 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VPKFLPRLARQAGVVPSHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLAV 68
            ||:  |::|....::...|:.|.:.....|   :.:|:.|...|.....||:|.|:|..|.|:||
Zfish    20 VPR--PKIAYALWIICPFMTDAYTHGFVCP---SDLSTLLAVPSRVRDMAVVGFDVGFQNCCIAV 79

  Fly    69 MEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVK 133
            ::....:.:.|....|.|||.::|... .|.:|..||.|.:||.::|.:..|||..|.:.|..|:
Zfish    80 VKSGGIETVSNEFTDRCTPSVISFGSK-NRAIGNAAKNQMITNPSSTVFHFKRLHSRLYHDKVVQ 143

  Fly   134 KDITNLSYKVVKASNGDAWVSSTDGKV------------YSPSQIGAFILMKMKETAEAYLNTPV 186
            .:..||.|.:|..:         ||||            :|..||.|.:|.|:|:.|||.|...|
Zfish   144 AEKANLPYDLVPLN---------DGKVGVQVMYLDQEHHFSIEQISAMLLTKLKDIAEANLQKKV 199

  Fly   187 KNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTED--------KIIAVY 243
            ...|:::|::|.||:|::..||.:|||||.|:::|:.||.||.||:.| ||        ||:|..
Zfish   200 LECVISIPSFFTDSERRSVLDAAKIAGLNCLKLMNDSTAVALNYGIYK-EDLPGSDENPKIVAFV 263

  Fly   244 DLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRL 308
            |||...|.:||....:|..:|.||..|..|||:|||..:|:...||||....:|::....|:.||
Zfish   264 DLGHSAFQVSICAFNRGKVKVLSTAFDPYLGGKDFDQRLVDHFCAEFKSKYMMDVKSKTRALLRL 328

  Fly   309 KEAAEKAKCELSSSQQTDINLPYLTM----DAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369
            .:..||.| :|.||..|:::|.....    |..|      ::.|:|.|.:..|||:|......||
Zfish   329 TQECEKLK-KLMSSNSTELSLNIECFIDDKDVCG------RMNRAKFEEMCADLIERVKFTLMKA 386

  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL--AGDV 432
            :..|.|...:|..|.:|||.||:|.|::.:...|.|..|.::|.|||||.|.|:|..:|  |..|
Zfish   387 VEQAGVRLQDISAVEIVGGATRIPAVKAQISSFFRRDVSTTLNADEAVARGCALQCAMLSPAFRV 451

  Fly   433 TDVLLLDVTPLSLGIE-----TLGGVFTRLISRNTTIPT--------------------KKSQVF 472
            .:..:.||.|..:.:.     ..|.....:.|||...|:                    |.|..|
Zfish   452 REFSITDVIPFPISLSWSSEADEGKSCHEIFSRNHPCPSAKMITFYRNKPFILEAFYSDKSSLPF 516

  Fly   473 STASDGQTQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDK 537
            ..|..|:.:|:....|..||.|                      :::|..:::.:|:|.||:
Zfish   517 PEAKIGEYKVQNIQPQENREKA----------------------KVKVKVEVNRSGVVSVSS--- 556

  Fly   538 GTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEF--- 599
                 ..:|::...  .:.||..:.:..:.:..:|..                |.:.|.||.
Zfish   557 -----AAVVLRVRS--DESEITEINEDVDSHDASDDT----------------DVQDKTEEVNIE 598

  Fly   600 ----KSQLPAEECEKLKKEIADLRTLLANKE-TADLEEVRKATSSLQQSSLKLFELAYKKMSAER 659
                |..||..:|..::||.....||..|.| .:.....:||...::...|.:.|...:::..:|
Zfish   599 LSVNKENLPTAQCPPMEKEQNQRETLSMNGEVNSHPPHAKKAKMKVKHVVLPMEETFNQQLPKDR 663

  Fly   660 ESNAGAGSSDSSSSSDTSGEAKKEEKN 686
            .| |.....:.....|...:.:...||
Zfish   664 LS-AYTEQENKMIQQDRQEKERNNAKN 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	195/673 (29%)
		HSPA9-like_NBD	51..428	CDD:212683	144/400 (36%)
		Syntaphilin	<566..>642	CDD:291936	17/83 (20%)
hsph1	XP_001919957.2	HSPH1_NBD	64..446	CDD:212689	144/399 (36%)
hsph1	XP_001919957.2	HSP70	65..761	CDD:278441	197/692 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900