Protein Alignment Hsc70-5 and HSPA14

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_057383.2
• Gene: HSPA14 / 51182
• HGNCID: 29526
• Length: 509
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 159/515 - (30%)
• Similarity: 269/515 - (52%)
• Gaps: 29/515 - (5%)

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            |.||:.||.|::|:||.:..:|.|:.|..|.|.||:.||:: :.|.:||:.||:..:.|.:||..
Human     2 AAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYS-ENEEIVGLAAKQSRIRNISNTVM 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG---KVYSPSQIGAFILMKMKETAE 179
            ..|:::||...||:.:|.|......|:: .||........|   |..:|..:...|..||||||.
Human    66 KVKQILGRSSSDPQAQKYIAESKCLVIE-KNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAH 129

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK---TEDKIIA 241
            :.|.:...:.|:|||..|.:.|:.|..:|.:.||.||||:|:||:||.||||:.:   |....|.
Human   130 SVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNIL 194

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            |:.|||.:..:|::|:..|::.|.|||.|..:||..|...:..:|.:||::....|:|.:..||.
Human   195 VFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMM 259

  Fly   307 RLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALS 371
            :|..:||.||..||:....:..|..|...    |..:..::|::.|.|...|..:.|:..:..|.
Human   260 KLTNSAEVAKHSLSTLGSANCFLDSLYEG----QDFDCNVSRARFELLCSPLFNKCIEAIRGLLD 320

  Fly   372 DAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPS----RSVNPDEAVAVGAAVQGGVLAGD- 431
            ....:..:|.:|:|.||.:|:||:|..:::||   |:    .|:.|||.:.:|||::.|:|.|.
Human   321 QNGFTADDINKVVLCGGSSRIPKLQQLIKDLF---PAVELLNSIPPDEVIPIGAAIEAGILIGKE 382

  Fly   432 ---VTDVLLLDVTP---LSLGIETLGGV-FTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQG 489
               |.|.|:::.:.   |..|::..|.. ||.|....|.:|.::..... |....:.|.:::::.
Human   383 NLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQ-APGSISSVCLELYES 446

  Fly   490 E-REMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQ 548
            : :..|.:........|..:.....|:..|..|..:..:|.:||:..|:.|||.:.|.|:
Human   447 DGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	159/515 (31%)
HSPA14	NP_057383.2	ASKHA_NBD_HSP70_HSPA14	2..378	CDD:466836	130/384 (34%)