DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and HSPA14

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_057383.2	Gene:	HSPA14 / 51182	HGNCID:	29526	Length:	509	Species:	Homo sapiens

Alignment Length:	515	Identity:	159/515 - (30%)
Similarity:	269/515 - (52%)	Gaps:	29/515 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            |.||:.||.|::|:||.:..:|.|:.|..|.|.||:.||:: :.|.:||:.||:..:.|.:||..
Human     2 AAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYS-ENEEIVGLAAKQSRIRNISNTVM 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG---KVYSPSQIGAFILMKMKETAE 179
            ..|:::||...||:.:|.|......|:: .||........|   |..:|..:...|..||||||.
Human    66 KVKQILGRSSSDPQAQKYIAESKCLVIE-KNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAH 129

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK---TEDKIIA 241
            :.|.:...:.|:|||..|.:.|:.|..:|.:.||.||||:|:||:||.||||:.:   |....|.
Human   130 SVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNIL 194

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            |:.|||.:..:|::|:..|::.|.|||.|..:||..|...:..:|.:||::....|:|.:..||.
Human   195 VFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMM 259

  Fly   307 RLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALS 371
            :|..:||.||..||:....:..|..|...    |..:..::|::.|.|...|..:.|:..:..|.
Human   260 KLTNSAEVAKHSLSTLGSANCFLDSLYEG----QDFDCNVSRARFELLCSPLFNKCIEAIRGLLD 320

  Fly   372 DAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPS----RSVNPDEAVAVGAAVQGGVLAGD- 431
            ....:..:|.:|:|.||.:|:||:|..:::||   |:    .|:.|||.:.:|||::.|:|.|.
Human   321 QNGFTADDINKVVLCGGSSRIPKLQQLIKDLF---PAVELLNSIPPDEVIPIGAAIEAGILIGKE 382

  Fly   432 ---VTDVLLLDVTP---LSLGIETLGGV-FTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQG 489
               |.|.|:::.:.   |..|::..|.. ||.|....|.:|.::..... |....:.|.:::::.
Human   383 NLLVEDSLMIECSARDILVKGVDESGASRFTVLFPSGTPLPARRQHTLQ-APGSISSVCLELYES 446

  Fly   490 E-REMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQ 548
            : :..|.:........|..:.....|:..|..|..:..:|.:||:..|:.|||.:.|.|:
Human   447 DGKNSAKEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	159/515 (31%)
		HSPA9-like_NBD	51..428	CDD:212683	130/384 (34%)
		Syntaphilin	<566..>642	CDD:291936
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	129/382 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900