DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa14

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_056580.2	Gene:	Hspa14 / 50497	MGIID:	1354164	Length:	509	Species:	Mus musculus

Alignment Length:	523	Identity:	152/523 - (29%)
Similarity:	270/523 - (51%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            |.||:.||.|::|:||.:..:|.|:.|..|.|.||:.||:: :.|::||:.||:..:.:.::|..
Mouse     2 AAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAIVAYS-EREQVVGLAAKQSRIRHVSSTVV 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG---KVYSPSQIGAFILMKMKETAE 179
            ..|:::||...||:.:|.|:.....|:: .||........|   |:.:|..:...|..||||||.
Mouse    66 KVKQILGRSSADPQAQKYISESKCLVIE-KNGKLRYEIDTGEETKLVNPEDVARLIFSKMKETAH 129

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK---TEDKIIA 241
            :.|.:...:.|||||..|.:.|:.|..:|...||.||||:|:||:||.||||:.:   |....:.
Mouse   130 SVLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDHPTGKSNVL 194

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            |:.|||.:..:|::|:..|::.|.|||....:||..|.:.:..:|.:||::....|:|.:..||.
Mouse   195 VFKLGGTSLSLSVMEVNSGMYRVLSTNTSDNIGGAHFTDTLAQYLASEFQRLFKHDVRGNARAMM 259

  Fly   307 RLKEAAEKAKCELSSSQQTDINLPYLTMDAAG--------PQHMNLKLTRSKLESLVGDLIKRTI 363
            :|..:||.||..||            |:.:|.        .|..:..::|::.|.|...|..:..
Mouse   260 KLMNSAEVAKHSLS------------TLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCT 312

  Fly   364 QPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPS----RSVNPDEAVAVGAAVQ 424
            :..::.|.....:..:|.:|:|.||.:|:||:|..:::||   |:    .|:.|||.:.:|||::
Mouse   313 EAIRELLRQTGFTADDINKVVLCGGSSRIPKLQQLIKDLF---PAVDLLNSIPPDEVIPIGAAIE 374

  Fly   425 GGVLAGDVT----DVLLLDVTP---LSLGIETLGG-VFTRLISRNTTIPTKKSQVFSTASDGQTQ 481
            .|:|.|..:    |.::::.:.   |..|::..|. .||.|....|.:|.::..... |....:.
Mouse   375 AGILVGKESTSGDDSVMIECSAKDILVKGVDESGADRFTVLFPSGTPLPARRQHTLQ-APGRVSS 438

  Fly   482 VEIKVHQGE-REMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQI 545
            |.:::::.| :..|.:........|..:.....|:..|..|..:..:|.:.|:..|:.|||.:.|
Mouse   439 VCLELYESEGKNSAKEEAKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQDTGKCEAI 503

  Fly   546 VIQ 548
            .::
Mouse   504 TVE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	152/523 (29%)
		HSPA9-like_NBD	51..428	CDD:212683	126/392 (32%)
		Syntaphilin	<566..>642	CDD:291936
Hspa14	NP_056580.2	HSPA14-like_NBD	2..376	CDD:212680	125/390 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900