DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and AgaP_AGAP007682

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_001237047.2	Gene:	AgaP_AGAP007682 / 4576741	VectorBaseID:	AGAP007682	Length:	1169	Species:	Anopheles gambiae

Alignment Length:	672	Identity:	212/672 - (31%)
Similarity:	323/672 - (48%)	Gaps:	104/672 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119
            ||||.||:.|.:.:....:.::|.|..|....||.||||:.| ||||..|..||.|:.||.....
Mosquito    30 IGIDFGTSFSSVGIYRNGKFEIIANECGNHRIPSVVAFTEKG-RLVGEEALAQADTDPANCVIEV 93

  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAFILMKMKETAEAYLNT 184
            ||::||.                  |...|.......:.|.|.|.:|...||..::..||..|..
Mosquito    94 KRILGRH------------------KKEGGLQVQFKGETKCYQPEEICGIILAHLRSMAERQLGE 140

  Fly   185 PVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKIIAVYDLGG 247
            ||..|||.|||.|:|.||||..||..||||:|||:||||||||::.|::|  ..::.:.|...||
Mosquito   141 PVTCAVVAVPAQFSDGQRQAVLDAATIAGLSVLRLINEPTAAAISIGINKKLIGEQYVLVCSFGG 205

  Fly   248 GTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAA 312
            |..|:||:.|..|||:||:::|||.|||.|.|..:|::.|.|.:....:||.:|.|||::|::..
Mosquito   206 GFLDVSIVTIYNGVFQVKASSGDTRLGGVDIDKRLVDYFVKELQDTQSLDITRDCIAMRKLRKTC 270

  Fly   313 EKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSK 377
            |:||..||.:.|..:.:.    |......::..||:..::.|..||.:|.|...:.||..|...:
Mosquito   271 EQAKRTLSYTSQVTVEID----DLLDGHKLSSTLTKDNVDELCKDLFERVILHVETALRRARKDR 331

  Fly   378 SEIGEVLLVGGMTRMPKVQSTVQELFGRQP-SRSVNPDEAVAVGAAVQGGVLAGD----VTDVLL 437
            ..:.|::|||..:|:|:||..:.|.|.|:. |.|||.||||.||.|:..|:|:||    :.|:|.
Mosquito   332 FAMHEIMLVGESSRIPRVQIMLSEFFDRRSLSSSVNSDEAVVVGTAIAAGILSGDKSCAIQDLLW 396

  Fly   438 LDVTPLSLGI--ETL-------GGVFTR----LISRNTTIPTK---KSQVFSTASDGQTQVEIKV 486
            .|:.|.|:|:  |.|       ||....    |||||:|:|.|   :.:.|....        ::
Mosquito   397 WDLVPRSIGMISEELDIDGGDGGGDVGEPPRILISRNSTLPLKVRHRVKNFRNVH--------RL 453

  Fly   487 HQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAK---------DKG---- 538
            ::||..:.:||..||...|.|  ....|:..:.:.|::|.||::||..:         |||
Mosquito   454 YEGESAIVSDNITLGRLQLEG--SFGEGLEDVGLSFNVDLNGVLHVMVEGNIELKATLDKGRLER 516

  Fly   539 ------TGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKME 597
                  ..:.::::::...|..:.| :...|:.:..|..|:|..|     .:.|:....|....:
Mosquito   517 YEIDRIVYEHKRLILEMERGQEEQE-QRKRKETDHSAVIDRQGEE-----QEAEADDGGTVGTWD 575

  Fly   598 EFKSQLPAEECEKLKKEIADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESN 662
            .|...|..........|:.....|:..|.          .:..:|..:.:..||:.      :||
Mosquito   576 RFSEWLHCICVVTFDLELGQAMELIYPKH----------VTLTEQEKMNICYLAFP------DSN 624

  Fly   663 AGA-GSSD------SSSSSDTS 677
            :|. |.|.      .||.|:.|
Mosquito   625 SGCMGDSQFHIRLRVSSGSENS 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	206/653 (32%)
		HSPA9-like_NBD	51..428	CDD:212683	146/375 (39%)
		Syntaphilin	<566..>642	CDD:291936	11/75 (15%)
AgaP_AGAP007682	XP_001237047.2	prok_dnaK	29..568	CDD:274091	194/576 (34%)
		NBD_sugar-kinase_HSP70_actin	29..384	CDD:302596	146/376 (39%)
		DENN	691..>850	CDD:299760
		SPA	799..902	CDD:285780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820