DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and CG7182

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	135/529 - (25%)
Similarity:	229/529 - (43%)	Gaps:	95/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GIDLGTTNSCLAVM--EGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAK-------RQAVTN 111
            ||.:|.:..|:|.:  :|| |:||.|.:|.|.:.:.:.:....|...|:.||       ||||.:
  Fly     6 GIKIGNSTLCIAHVRADGK-AEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAH 69

  Fly   112 SANTFYATKRLIGRR-----------FDDPEVKKDITNLSYKVVK-ASNGDAWVSSTDGKVYSPS 164
            |.......:.|...:           ||..|:   :..:.:.|.. ..:.|..|.:.|...|
  Fly    70 SFQLLQPKEELTEEKLSSALREIPCDFDKEEL---VFRMEHTVPSDREDQDDRVVTKDLSAY--- 128

  Fly   165 QIGAFILMKMKETAEAY----LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTA 225
            |:...:|....|.|..|    ...|:  ||:::|:|:..|..:...||.|.||.:|.::|.||||
  Fly   129 QVTVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTA 191

  Fly   226 AALAY--GMDKTED-KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLV 287
            |.|.|  |.::||. :.:.....||...||:...:|.|:|...:|.|...:||..|...:|.|:.
  Fly   192 AVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQFIC 256

  Fly   288 AEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLE 352
            .||::...:|..:...::.:::.||...|..|::...|.:.:..| ||..   ..|.:::|::.|
  Fly   257 EEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSL-MDGV---DYNAQMSRARFE 317

  Fly   353 SLVGDLIKRTIQPCQKALSDAEVSK---SEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNP 413
            ||:..:|...||...:.:..|:...   |:|.:::|:|...::||:|:.|...| ..:...|.:.
  Fly   318 SLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSA 382

  Fly   414 DEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGIE-----TLGGVF----------TRLISRNTT 463
            ||.||:|.|.|.         |.|:|.....|..|     ....:|          ..::.|.:.
  Fly   383 DEVVAIGCARQA---------VCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLGRGSV 438

  Fly   464 IPTKKSQVFSTASDGQTQVEIKVHQGEREMAND-NKLLGSF--------TLVGIPPA--PR-GVP 516
            :|.|              :.|.:.|.|....:| :|...||        .|..:|.:  |. |:.
  Fly   439 LPAK--------------IRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIPEDGLY 489

  Fly   517 QIEVVFDID 525
            |:||..|:|
  Fly   490 QLEVEVDVD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	135/529 (26%)
		HSPA9-like_NBD	51..428	CDD:212683	110/403 (27%)
		Syntaphilin	<566..>642	CDD:291936
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	109/400 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930