DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and hspa4b

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_956151.1	Gene:	hspa4b / 334086	ZFINID:	ZDB-GENE-030131-6018	Length:	840	Species:	Danio rerio

Alignment Length:	660	Identity:	180/660 - (27%)
Similarity:	304/660 - (46%)	Gaps:	94/660 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            :|:|.|:|..|..:||......:.:.|....|.||:.|:| ....|.:|..||.|.|||..||.:
Zfish     2 SVVGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSF-GPRNRSIGAAAKSQMVTNCKNTVH 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAE 179
            ..||..||.|.||.|:....:|.|.:.:..:|...:.   ..:.||:|..|:.|.:|.|:|||||
Zfish    66 GFKRFHGRAFSDPFVQNLKPSLVYDLAQMPSGTTGLKVMYMEEEKVFSIEQVTAMLLTKLKETAE 130

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-------D 237
            :.|..||.:.|::||.::.|::|::..||.||||||.||::||.||.|||||:.|.:       .
Zfish   131 SALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYGIYKQDLPAPEEKP 195

  Fly   238 KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDN 302
            :.:...|:|...:.:|:....||..::.:|..|..:||:.||..:|.:...||.....:|.:...
Zfish   196 RNVVFVDIGHSGYQVSVCAFNKGKLKILATAFDPEMGGKYFDERLVKYFCEEFVVKYKLDAKTKP 260

  Fly   303 IAMQRLKEAAEKAKCELSSSQQTD--INLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQP 365
            .|:.||.:..||.| :|.|:..:|  :|:.....|.    .::.:|.|::.|.:..|::.|...|
Zfish   261 RALIRLFQECEKLK-KLMSANSSDLPLNIECFMNDV----DVSSRLNRAQFEEMCADILARVEPP 320

  Fly   366 CQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL-- 428
            .:..|..|.:.|.:|..|.:|||.:|||.::..:.:.||::||.::|.|||||.|.|:|..:|
Zfish   321 LRSLLEQAHLKKDDIHAVEIVGGASRMPAIKERISKFFGKEPSTTLNADEAVARGCALQCAILSP 385

  Fly   429 AGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEI--------- 484
            |..|.:..:.:|.|..:.::.                      .|.|.||.:..|:
Zfish   386 AFKVREFSITEVVPFPISLKW----------------------NSAAEDGVSDCEVFPKNHAAPF 428

  Fly   485 -KV--------------HQGEREMANDNKLLGSFTLVGIPPAPRG-VPQIEVVFDIDANGIVHVS 533
             ||              :...:|:...:..:|.:.:..:.|...| ..:::|...::.:||..||
Zfish   429 SKVLTFYRREPFTLDAYYNSPKELPYPDPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVS 493

  Fly   534 AK-----DKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESI--VHD 591
            :.     .|...:|:.:..:.|   ::.|.||.::..:|.....:.::|      .||..  ..:
Zfish   494 SASLVEVQKSEEEEESMETEQS---TEKENENKMQVDQEEQKTPETEQE------NGEKKPGTEE 549

  Fly   592 TETKMEEFKSQLPAEECEKLKKEIADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKM- 655
            .||..||.|.:..:::..:.||.....:.|       ||.........|....|.||..:..||
Zfish   550 METSAEEGKQEKKSDQPPQAKKPKVKTKVL-------DLPIENNPQWQLANDMLNLFVESEGKMI 607

  Fly   656 ---SAERESN 662
               ..|:|.|
Zfish   608 MQDKLEKERN 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	180/660 (27%)
		HSPA9-like_NBD	51..428	CDD:212683	130/386 (34%)
		Syntaphilin	<566..>642	CDD:291936	15/77 (19%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	130/387 (34%)
hspa4b	NP_956151.1	HSP70	3..693	CDD:278441	180/659 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900