DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and HSPA6

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_002146.2	Gene:	HSPA6 / 3310	HGNCID:	5239	Length:	643	Species:	Homo sapiens

Alignment Length:	633	Identity:	306/633 - (48%)
Similarity:	417/633 - (65%)	Gaps:	19/633 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119
            :|||||||.||:.|.:..:.:::.|.:|.|||||:|||| |.|||||..||.||..|..||.:..
Human     9 VGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFT-DTERLVGDAAKSQAALNPHNTVFDA 72

  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181
            ||||||:|.|..|:.|:.:..::|| :..|...|.   ..:.|.:.|.:|.:.:|.|||||||||
Human    73 KRLIGRKFADTTVQSDMKHWPFRVV-SEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAY 136

  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKIIAVYD 244
            |..|||:||:||||||||||||||||||.||||||||:||||||||:|||:|:  ..::.:.::|
Human   137 LGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFD 201

  Fly   245 LGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLK 309
            |||||||:|:|.|..||||||:|.|||.||||||||.:||..:.||::..|.|:..:..|::||:
Human   202 LGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266

  Fly   310 EAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAE 374
            .|.|:||..||||.|..:.:..|....    .....:||::.|.|..||.:.|::|.:|||.||:
Human   267 TACERAKRTLSSSTQATLEIDSLFEGV----DFYTSITRARFEELCSDLFRSTLEPVEKALRDAK 327

  Fly   375 VSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD----VTD 434
            :.|::|.:|:||||.||:||||..:|:.| |::.::|:|||||||.|||||..||.||    |.|
Human   328 LDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQD 392

  Fly   435 VLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKL 499
            :|||||.|||||:||.|||.|.||.||.|||||::|.|:|.||.|..|.|:|::|||.|..||.|
Human   393 LLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNL 457

  Fly   500 LGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENMIK 563
            ||.|.|.||||||||||||||.||||||||:.|:|.|:.|||..:|.| ...|.|||:|:|.|:.
Human   458 LGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVH 522

  Fly   564 KAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLRTLLANKE 626
            :||:|...|:.:|:.:...|..|:.|...:..::|  .:.::|.|:..|::.:..::...|.:.:
Human   523 EAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQ 587

  Fly   627 TADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSS 674
            .|:.||.......|:|....:|...|........|:.|..:.....|:
Human   588 LAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPST 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	305/623 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	195/378 (52%)
		Syntaphilin	<566..>642	CDD:291936	16/77 (21%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		199/384 (52%)
		HSP70	8..643	CDD:331774	306/633 (48%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		73/114 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..643		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820