Protein Alignment Hsc70-5 and HSPA6

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_002146.2
• Gene: HSPA6 / 3310
• HGNCID: 5239
• Length: 643
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 306/633 - (48%)
• Similarity: 417/633 - (65%)
• Gaps: 19/633 - (3%)

  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119
            :|||||||.||:.|.:..:.:::.|.:|.|||||:|||| |.|||||..||.||..|..||.:..
Human     9 VGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFT-DTERLVGDAAKSQAALNPHNTVFDA 72

  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181
            ||||||:|.|..|:.|:.:..::|| :..|...|.   ..:.|.:.|.:|.:.:|.|||||||||
Human    73 KRLIGRKFADTTVQSDMKHWPFRVV-SEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAY 136

  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKIIAVYD 244
            |..|||:||:||||||||||||||||||.||||||||:||||||||:|||:|:  ..::.:.::|
Human   137 LGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFD 201

  Fly   245 LGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLK 309
            |||||||:|:|.|..||||||:|.|||.||||||||.:||..:.||::..|.|:..:..|::||:
Human   202 LGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266

  Fly   310 EAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAE 374
            .|.|:||..||||.|..:.:..|....    .....:||::.|.|..||.:.|::|.:|||.||:
Human   267 TACERAKRTLSSSTQATLEIDSLFEGV----DFYTSITRARFEELCSDLFRSTLEPVEKALRDAK 327

  Fly   375 VSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD----VTD 434
            :.|::|.:|:||||.||:||||..:|:.| |::.::|:|||||||.|||||..||.||    |.|
Human   328 LDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQD 392

  Fly   435 VLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKL 499
            :|||||.|||||:||.|||.|.||.||.|||||::|.|:|.||.|..|.|:|::|||.|..||.|
Human   393 LLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNL 457

  Fly   500 LGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENMIK 563
            ||.|.|.||||||||||||||.||||||||:.|:|.|:.|||..:|.| ...|.|||:|:|.|:.
Human   458 LGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVH 522

  Fly   564 KAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLRTLLANKE 626
            :||:|...|:.:|:.:...|..|:.|...:..::|  .:.::|.|:..|::.:..::...|.:.:
Human   523 EAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQ 587

  Fly   627 TADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSS 674
            .|:.||.......|:|....:|...|........|:.|..:.....|:
Human   588 LAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPST 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	305/623 (49%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		199/384 (52%)
		PTZ00009	8..643	CDD:240227	306/633 (48%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		73/114 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..643		3/20 (15%)