DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-5 and HSPA5

DIOPT Version :9

Sequence 1:NP_001286414.1 Gene:Hsc70-5 / 36583 FlyBaseID:FBgn0001220 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens


Alignment Length:646 Identity:319/646 - (49%)
Similarity:431/646 - (66%) Gaps:33/646 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 GAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            |.|:|||||||.||:.|.:..:.::|.|.:|.|.|||:||||.:||||:|..||.|..:|..||.
Human    28 GTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV 92

  Fly   117 YATKRLIGRRFDDPEVKKDITNLSYKVVKASNG---DAWVSSTDGKVYSPSQIGAFILMKMKETA 178
            :..||||||.::||.|::||..|.:|||:....   ...:.....|.::|.:|.|.:|.||||||
Human    93 FDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETA 157

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-DKIIAV 242
            ||||...|.:|||||||||||:|||||||||.||||||:|:||||||||:|||:||.| :|.|.|
Human   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILV 222

  Fly   243 YDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQR 307
            :||||||||:|:|.|..|||||.:|||||.|||||||..::...:..:||.:|.|:||||.|:|:
Human   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQK 287

  Fly   308 LKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKAL 370
            |:...||||..|||..|..|.:.  |...|      .:..|||:|.|.|..||.:.|::|.||.|
Human   288 LRREVEKAKRALSSQHQARIEIESFYEGED------FSETLTRAKFEELNMDLFRSTMKPVQKVL 346

  Fly   371 SDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG--DV 432
            .|:::.||:|.|::||||.||:||:|..|:|.| |::|||.:|||||||.|||||.|||:|  |.
Human   347 EDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDT 411

  Fly   433 TDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDN 497
            .|::||||.||:|||||:|||.|:||.|||.:||||||:||||||.|..|.|||::|||.:..||
Human   412 GDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDN 476

  Fly   498 KLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENM 561
            .|||:|.|.||||||||||||||.|:||.|||:.|:|:|||||.:.:|.| .....|:.:|||.|
Human   477 HLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERM 541

  Fly   562 IKKAEEYATADKQKRELIEIVNQGESIVHDTETKM---EEFKSQLPAEECEKLKKEIADLRTLLA 623
            :..||::|..||:.:|.|:..|:.||..:..:.::   |:...:|.:|:.|.::|.:.:....|.
Human   542 VNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLE 606

  Fly   624 NKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEE 684
            :.:.||:|:.:.....|::....:....|           |:.....:...||   |:|:|
Human   607 SHQDADIEDFKAKKKELEEIVQPIISKLY-----------GSAGPPPTGEEDT---AEKDE 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-5NP_001286414.1 dnaK 51..666 CDD:234715 314/626 (50%)
HSPA9-like_NBD 51..428 CDD:212683 206/382 (54%)
Syntaphilin <566..>642 CDD:291936 19/78 (24%)
HSPA5NP_005338.1 Required for interaction with KIAA1324. /evidence=ECO:0000269|PubMed:26045166 1..80 28/51 (55%)
HSP70 30..635 CDD:394970 311/610 (51%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 92/154 (60%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 4/9 (44%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 56/79 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 7/35 (20%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237853at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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