DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and HSPA2

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001374860.1	Gene:	HSPA2 / 3306	HGNCID:	5235	Length:	639	Species:	Homo sapiens

Alignment Length:	658	Identity:	315/658 - (47%)
Similarity:	425/658 - (64%)	Gaps:	48/658 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            :|..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Human     4 RGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 67

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKET 177
            .:..||||||:|:|..|:.|:.:..::|| :..|...|.   ..:.|.:.|.:|.:.:|.||||.
Human    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVV-SEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEI 131

  Fly   178 AEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT----EDK 238
            |||||...|.:||:||||||||||||||||||.|.||||||:||||||||:|||:||.    .:|
Human   132 AEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEK 196

  Fly   239 IIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI 303
            .:.::||||||||:|||.|:.|:||||||.|||.||||||||.:|:.|..|||:....||..:..
Human   197 NVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKR 261

  Fly   304 AMQRLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPC 366
            |::||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|::|.
Human   262 AVRRLRTACERAKRTLSSSTQASIEIDSLYEGVD------FYTSITRARFEELNADLFRGTLEPV 320

  Fly   367 QKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG 430
            :|||.||::.|.:|.|::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|.|
Human   321 EKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIG 385

  Fly   431 D----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGER 491
            |    |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|:.|.::|::|||
Human   386 DKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER 450

  Fly   492 EMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSK 555
            .|..||.|||.|.|.||||||||||||||.||||||||::|:|.||.||||.:|.| ...|.|||
Human   451 AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSK 515

  Fly   556 DEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRT 620
            |:|:.|:::||.|.:.|:..|:.:...|..||..::.:..:|:          |||:.:|::
Human   516 DDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVED----------EKLRGKISE--- 567

  Fly   621 LLANKETADLEEVRKATSSLQQSSL-KLFELAYKKMSAERESN--------AGAGSSDSSSSSDT 676
               ..:...|::.::..:.|.::.: :..|..:|:...||..|        .|.|.......|..
Human   568 ---QDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGA 629

  Fly   677 SGEAKKEE 684
            ||....||
Human   630 SGGPTIEE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	309/638 (48%)
		HSPA9-like_NBD	51..428	CDD:212683	197/386 (51%)
		Syntaphilin	<566..>642	CDD:291936	14/75 (19%)
HSPA2	NP_001374860.1	PTZ00009	2..615	CDD:240227	308/634 (49%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		200/392 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		77/114 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..639		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820