Protein Alignment Hsc70-5 and HSPA2

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 315/658 - (47%)
• Similarity: 425/658 - (64%)
• Gaps: 48/658 - (7%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            :|..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Human     4 RGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 67

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKET 177
            .:..||||||:|:|..|:.|:.:..::|| :..|...|.   ..:.|.:.|.:|.:.:|.||||.
Human    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVV-SEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEI 131

  Fly   178 AEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT----EDK 238
            |||||...|.:||:||||||||||||||||||.|.||||||:||||||||:|||:||.    .:|
Human   132 AEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEK 196

  Fly   239 IIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI 303
            .:.::||||||||:|||.|:.|:||||||.|||.||||||||.:|:.|..|||:....||..:..
Human   197 NVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKR 261

  Fly   304 AMQRLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPC 366
            |::||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|::|.
Human   262 AVRRLRTACERAKRTLSSSTQASIEIDSLYEGVD------FYTSITRARFEELNADLFRGTLEPV 320

  Fly   367 QKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG 430
            :|||.||::.|.:|.|::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|.|
Human   321 EKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIG 385

  Fly   431 D----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGER 491
            |    |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|:.|.::|::|||
Human   386 DKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER 450

  Fly   492 EMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSK 555
            .|..||.|||.|.|.||||||||||||||.||||||||::|:|.||.||||.:|.| ...|.|||
Human   451 AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSK 515

  Fly   556 DEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRT 620
            |:|:.|:::||.|.:.|:..|:.:...|..||..::.:..:|:          |||:.:|::
Human   516 DDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVED----------EKLRGKISE--- 567

  Fly   621 LLANKETADLEEVRKATSSLQQSSL-KLFELAYKKMSAERESN--------AGAGSSDSSSSSDT 676
               ..:...|::.::..:.|.::.: :..|..:|:...||..|        .|.|.......|..
Human   568 ---QDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGA 629

  Fly   677 SGEAKKEE 684
            ||....||
Human   630 SGGPTIEE 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	309/638 (48%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	308/634 (49%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		200/392 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		77/114 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		7/25 (28%)