DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-5 and HSPA1B

DIOPT Version :9

Sequence 1:NP_001286414.1 Gene:Hsc70-5 / 36583 FlyBaseID:FBgn0001220 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_005337.2 Gene:HSPA1B / 3304 HGNCID:5233 Length:641 Species:Homo sapiens


Alignment Length:646 Identity:316/646 - (48%)
Similarity:425/646 - (65%) Gaps:26/646 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            |.|.||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Human     3 KAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGD---AWVS-STDGKVYSPSQIGAFILMKMKE 176
            .:..||||||:|.||.|:.|:.:..::|:  ::||   ..|| ..:.|.:.|.:|.:.:|.||||
Human    67 VFDAKRLIGRKFGDPVVQSDMKHWPFQVI--NDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKE 129

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKI 239
            .|||||..||.|||:||||||||||||||||||.||||||||:||||||||:|||:|:|  .::.
Human   130 IAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN 194

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|..|:||||:|.|||.||||||||.:||..|.|||:....||.::..|
Human   195 VLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRA 259

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..:.:..|  .:|      ....:||::.|.|..||.:.|::|.:
Human   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGID------FYTSITRARFEELCSDLFRSTLEPVE 318

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |||.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
Human   319 KALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGD 383

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.|||||:||.|||.|.||.||:|||||::|:|:|.||.|..|.|:|::|||.
Human   384 KSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERA 448

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:
Human   449 MTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKE 513

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLR 619
            |||.|:::||:|...|:.:||.:...|..||...:.::.:|:  .|.::...:.:|:..:..::.
Human   514 EIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVI 578

  Fly   620 TLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGA-GSSDSSSSSDTSGE 679
            :.|.....|:.:|.......|:|....:....|:..........|| |....|.|..|..|
Human   579 SWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-5NP_001286414.1 dnaK 51..666 CDD:234715 311/631 (49%)
HSPA9-like_NBD 51..428 CDD:212683 202/385 (52%)
Syntaphilin <566..>642 CDD:291936 15/77 (19%)
HSPA1BNP_005337.2 PTZ00009 1..611 CDD:240227 308/616 (50%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 205/391 (52%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 74/114 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..641 7/26 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D288077at2759
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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