Protein Alignment Hsc70-5 and HSPA1A

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_005336.3
• Gene: HSPA1A / 3303
• HGNCID: 5232
• Length: 641
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 316/646 - (48%)
• Similarity: 425/646 - (65%)
• Gaps: 26/646 - (4%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            |.|.||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Human     3 KAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGD---AWVS-STDGKVYSPSQIGAFILMKMKE 176
            .:..||||||:|.||.|:.|:.:..::|:  ::||   ..|| ..:.|.:.|.:|.:.:|.||||
Human    67 VFDAKRLIGRKFGDPVVQSDMKHWPFQVI--NDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKE 129

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKI 239
            .|||||..||.|||:||||||||||||||||||.||||||||:||||||||:|||:|:|  .::.
Human   130 IAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN 194

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|..|:||||:|.|||.||||||||.:||..|.|||:....||.::..|
Human   195 VLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRA 259

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..:.:..|  .:|      ....:||::.|.|..||.:.|::|.:
Human   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGID------FYTSITRARFEELCSDLFRSTLEPVE 318

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |||.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
Human   319 KALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGD 383

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.|||||:||.|||.|.||.||:|||||::|:|:|.||.|..|.|:|::|||.
Human   384 KSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERA 448

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:
Human   449 MTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKE 513

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLR 619
            |||.|:::||:|...|:.:||.:...|..||...:.::.:|:  .|.::...:.:|:..:..::.
Human   514 EIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVI 578

  Fly   620 TLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGA-GSSDSSSSSDTSGE 679
            :.|.....|:.:|.......|:|....:....|:..........|| |....|.|..|..|
Human   579 SWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEE 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	311/631 (49%)
HSPA1A	NP_005336.3	PTZ00009	1..611	CDD:240227	308/616 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		205/391 (52%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		74/114 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..641		7/26 (27%)