DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and hyou1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_997868.1	Gene:	hyou1 / 327133	ZFINID:	ZDB-GENE-030131-5344	Length:	980	Species:	Danio rerio

Alignment Length:	770	Identity:	206/770 - (26%)
Similarity:	331/770 - (42%)	Gaps:	172/770 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVME-GKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            ||:.:|||:....:|::: |...:::.|.|..|.||..|.. |:.|||.|..|...||.|....:
Zfish    26 AVMSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCL-KENERLFGDGALGVAVKNPKVVY 89

  Fly   117 YATKRLIGRRFDDPEV------------KKDITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAF 169
            ...:.::|:..|:|:|            :||          ...|..:...::...|:|.::...
Zfish    90 RFLQSILGKTADNPQVAEYQKHFPEHQLQKD----------EKRGTVYFKFSEEMQYTPEELLGM 144

  Fly   170 ILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK 234
            ||...:..|:.:...|:|:||:|||||||.::|:|...|..||||.||::||:.||.||.||:.:
Zfish   145 ILNYSRTLAQDFAEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFR 209

  Fly   235 TED-----KIIAVYDLGGGTFDISILEIQ---------KGVFEVKSTNGDTLLGGEDFDNHIVNF 285
            .:|     :.|..||:|.|:...:|:..|         :...:::....|..|||.:.:..:.:.
Zfish   210 RKDINSTAQNIMFYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDH 274

  Fly   286 LVAEF--KKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTR 348
            |...|  :|.|..|:|.:..||.:|.:.|::.|..||::.:....:..|..|.    ....|:||
Zfish   275 LAKLFNEQKKSKKDVRDNLRAMAKLLKEAQRLKTVLSANAEHTAQIEGLMDDI----DFKAKVTR 335

  Fly   349 SKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQP-SRSVN 412
            |:.|:|..||..|...|.::||:.||:|..||.:|:||||.||:||||..:.:..|::. |:::|
Zfish   336 SEFEALCEDLFDRVPGPVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNIN 400

  Fly   413 PDEAVAVGAAVQGGVL--AGDVTDVLLLD--VTPLSL----------GIETLGGVFTRLISRNTT 463
            .|||.|:||..|...|  |..|...|:.|  |.|:.:          |:::|......|..|...
Zfish   401 ADEAAAMGAVYQAAALSKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAP 465

  Fly   464 IPTKKSQVFSTASDGQTQVEIKVHQGEREMAN--DNKLLGSFTLVGIPPAPRG------------ 514
            .|.:|...|:...|   .....::.|:....:  |.|:.||..|..:..:..|
Zfish   466 YPQRKVITFNRYID---DFVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSDAESK 527

  Fly   515 ---------------VPQIEVVFDI-----------------------------DANGIVHVSAK 535
                           :.::|.||:.                             .||....|:.:
Zfish   528 GIKAHFNMDESGVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDE 592

  Fly   536 DKGT---GKEQ-QIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKM 596
            ::.|   |||| |...|......|.|.|.. |:||..|...|:.:|..|  ||||:....||...
Zfish   593 EEVTPEAGKEQDQPEKQEETVQEKPETEEG-KEAEPQAEEQKEDKEKAE--NQGETESEKTEKPE 654

  Fly   597 E---------------EFKSQL----------------PAEECEKLKKEIADLRTLLANKETADL 630
            |               :.||::                .||:.|..||::.||       ...||
Zfish   655 EKTTDEEKEADMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDL-------TDRDL 712

  Fly   631 E--EVRKATSSLQ----QSSLKLFELAYKKMSAERESNAGAGS-SDSSSSSDTSG 678
            |  |..|..:||:    ::..||::..|:.:..|.|....:|. |.:||..|..|
Zfish   713 EKQEREKTLNSLEAFIFETQDKLYQDEYQAVVTEEEKEQISGRLSVASSWMDEEG 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	200/755 (26%)
		HSPA9-like_NBD	51..428	CDD:212683	127/404 (31%)
		Syntaphilin	<566..>642	CDD:291936	28/112 (25%)
hyou1	NP_997868.1	HSP70	27..705	CDD:278441	185/698 (27%)
		HYOU1-like_NBD	28..414	CDD:212672	125/400 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..682		29/126 (23%)
		PTPRCAP	<598..>648	CDD:292341	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..980
		Prevents secretion from ER. /evidence=ECO:0000255	977..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900