Protein Alignment Hsc70-5 and Hspa12b

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001381945.1
• Gene: Hspa12b / 311427
• RGDID: 1312004
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 735
• Identity: 152/735 - (20%)
• Similarity: 256/735 - (34%)
• Gaps: 238/735 - (32%)

  Fly     5 PKFLPRLARQAGVVPSHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLA-- 67
            |...||.....|:.|.             ..|.....::|.........|:.||.|||:|..|
  Rat    26 PPGSPRTQESCGIAPL-------------TPSQSPKPEVRAPQRASFSVVVAIDFGTTSSGYAFS 77

  Fly    68 -VMEGKQAKVIENAEGA------RTTPSHVAFTKDGERLVGMPAKRQAVTNS----ANTFYATKR 121
             ..:.:...::...||.      :.||:.:..|.:|            :.:|    |..:|...
  Rat    78 FATDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEG------------IFHSFGYTARDYYHDL- 129

  Fly   122 LIGRRFDDPEVKKD-------------ITNLSYKV-VKASNGDAWVSSTDGKVYSPSQ--IGAFI 170
                   |||..:|             .|:|:.|. ::|.||...::.   :|::.:.  .....
  Rat   130 -------DPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKKMLAL---EVFAHALRFFKEHA 184

  Fly   171 LMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL------NVLRVINEPTAAAL- 228
            |.:::|.:|..|.......|:||||.:....:|..::|..:|||      ..|.:..||.||::
  Rat   185 LQELREQSECMLEKDAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAASVY 249

  Fly   229 ----------------AYG---------------------------------------MDKTEDK 238
                            |.|                                       .:..|..
  Rat   250 CRKLRLHQLMDLSSRTAGGGRLGERRSIDSSFRHAREQLRRSRHSRTFLVESGVGELWSEMQEGD 314

  Fly   239 IIAVYDLGGGTFDISI--LEIQKGVFE--VKSTNG-----------DTLL---GGEDFDNHIVNF 285
            ...|.|.||||.|:::  ||...|..:  .|::.|           :.||   .||||
  Rat   315 RYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDF------- 372

  Fly   286 LVAEFKKD---SGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMN---- 343
             :|:||:.   :.:|:   .||.:..|..|...:     :...:|:||:..:|....|..:
  Rat   373 -IAKFKRQRPAAWVDL---TIAFEARKRTAGPHR-----AGALNISLPFSFIDFYRKQRGHNVET 428

  Fly   344 -----------------LKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTR 391
                             |:::...:..|....:...||..:..|:..||...::  :.||||...
  Rat   429 ALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEMLLAKPEVQGVKL--LFLVGGFAE 491

  Fly   392 MPKVQSTVQELFGRQPSRSVNPDEAVAVGAAV-QGGVLAGDVTDVLLLDVTPLSLGIETLGGVFT 455
            ...:|..|||..|.:..|.|.|.:   ||..: :|.||.|....|:.:..:||:.|:    ||..
  Rat   492 SAVLQHAVQEALGNRGLRVVVPHD---VGLTILKGAVLFGQAPGVVRVRRSPLTYGV----GVLN 549

  Fly   456 RLISRNTTIPTKKSQVFSTASDGQ---TQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQ 517
            |.:..:.  |.:|..|    .||:   |.|..:....|:.:|...::..|:.     ||..|  |
  Rat   550 RFVPGHH--PPEKLLV----RDGRRWCTDVFERFVAAEQSVALGEEVRRSYC-----PARPG--Q 601

  Fly   518 IEVVFDI------DANGIVHVSAKDKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKR 576
            ..|:.::      ||..|.     |.|        ::..|.||   :|...:.:.|.......:|
  Rat   602 RRVLINLYCCAAEDARFIT-----DPG--------VRKCGALS---LELEPEGSPENTGTSPSRR 650

  Fly   577 ELIEIVNQGESIVHDTETKM 596
            |:...:..|     |||.|:
  Rat   651 EIRAAMQFG-----DTEIKV 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	145/689 (21%)
		HSPA9-like_NBD	51..428	CDD:212683	103/510 (20%)
		Syntaphilin	<566..>642	CDD:291936	8/31 (26%)
Hspa12b	NP_001381945.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900