Protein Alignment Hsc70-5 and Hspa12a

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_017444569.1
• Gene: Hspa12a / 307997
• RGDID: 1305531
• Length: 691
• Species: Rattus norvegicus
• Alignment Length: 666
• Identity: 143/666 - (21%)
• Similarity: 233/666 - (34%)
• Gaps: 225/666 - (33%)

  Fly    54 VIGIDLGTTNSCLAVMEGKQAK---VIENAEGA------RTTPSHVAFTKDGERLVGMPAKRQAV 109
            |:.||.|||:|..|....|:.:   |:...||.      :.||:.:..|.:        .|..:.
  Rat    74 VVAIDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPE--------RKFHSF 130

  Fly   110 TNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAW----VSSTDGKVYSPSQIGAFI 170
            ..:|..||       ...|..|.|:.:....:|:...:.||..    :::.:||.....:|..:.
  Rat   131 GYAARDFY-------HDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFTYA 188

  Fly   171 LMKMKETA---------EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL------NVLRVI 220
            |...||.|         ..:.|:.|: .|:||||.:....:|..::|...|||      ..|.:.
  Rat   189 LQYFKEQALKELSDQAGSDFENSDVR-WVITVPAIWKQPAKQFMREAAYQAGLASPENSEQLIIA 252

  Fly   221 NEPTAAAL--------------------AYGMDKT------------------------------ 235
            .||.||::                    .|....|
  Rat   253 LEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRTFLVENVIGEI 317

  Fly   236 ------EDKIIAVYDLGGGTFDISILEIQ------KGVFEVKSTNG-----------DTLL---G 274
                  .||.:.| |.||||.|:::.:|:      |.::  |:|.|           :.||   .
  Rat   318 WSELEEGDKYVVV-DSGGGTVDLTVHQIRLPEGHLKELY--KATGGPYGSLGVDYEFEKLLCKIF 379

  Fly   275 GEDFDNHIVNFLVAEFK---KDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMD- 335
            ||||        :.:||   ..:.:|:.   ||.:..|.||...:     :...:|.||:..:|
  Rat   380 GEDF--------IEQFKIKRPAAWVDLM---IAFESRKRAAAPDR-----TNPLNITLPFSFIDY 428

  Fly   336 -----AAGPQHMNLKLTRSKLE--------------SLVGDLIKRTIQPCQKALSDAEVSKSEIG 381
                 ....:|   .|.:|.::              ..:..|.|.||....:.|.|. ..|.|:.
  Rat   429 YKKFRGHSVEH---ALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDL-FQKPEVS 489

  Fly   382 EV---LLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAV-QGGVLAGDVTDVLLLDVTP 442
            .|   .||||....|.:|..||..|| ...|.:.|.:   ||..: :|.||.|....|:.:..:|
  Rat   490 TVKFLFLVGGFAEAPLLQQAVQAAFG-DKCRIIIPQD---VGLTILKGAVLFGLDPAVIKVRRSP 550

  Fly   443 LSLGIETLG----------------------GVFTRLISRNTTIP----TKKSQVFSTASDGQTQ 481
            |:.|:..|.                      .||.:.||.:.::.    .|:|  ::.|...|..
  Rat   551 LTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRS--YTPAKPSQLV 613

  Fly   482 VEIKVHQGEREMANDN---------KLLGS--FTLVGIP----PAPRGVPQIEVVFDIDANGIVH 531
            :.|.::..|    ||:         |..|:  ..|.|..    ||.|.:..:....|.:    :.
  Rat   614 IIINIYSSE----NDDVSFITDPGVKKCGTLRLDLTGTSGAAVPARREIQTLMQFGDTE----IK 670

  Fly   532 VSAKDKGTGKEQQIVI 547
            .:|.|..|.|..::.|
  Rat   671 ATAVDIATSKSVKVGI 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	143/666 (21%)
		HSPA9-like_NBD	51..428	CDD:212683	110/504 (22%)
		Syntaphilin	<566..>642	CDD:291936
Hspa12a	XP_017444569.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900