DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa14

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001004257.1	Gene:	Hspa14 / 307133	RGDID:	1303296	Length:	509	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	156/523 - (29%)
Similarity:	269/523 - (51%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            |.||:.||.|::|:||.:..:|.|:.|..|.|.||:.||:: :.|::||:.||:..:.|.::|..
  Rat     2 AAIGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAVVAYS-EREQVVGLAAKQSRIRNISSTVV 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG---KVYSPSQIGAFILMKMKETAE 179
            ..|:::||...||:.:|.|:.....|:: .||........|   |:.||..:...|..||||||.
  Rat    66 KVKQILGRSTADPQAQKYISESKCLVIE-KNGKLQYEIDTGEETKLVSPEDVARLIFSKMKETAH 129

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK---TEDKIIA 241
            :.|.:...:.|||||..|.:.|:.|..:|...||.||||:|:||:||.||||:.:   |....:.
  Rat   130 SVLGSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDCPTGKSNVL 194

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            |:.|||.:..:||:|:..|::.|.|||....:||..|.:.:..:|.:||::....|:|....||.
  Rat   195 VFKLGGTSLSLSIMEVNSGMYRVLSTNTSDNIGGVHFTDSLAQYLASEFQRLFKHDVRGSARAMM 259

  Fly   307 RLKEAAEKAKCELSSSQQTDINLPYLTMDAAG--------PQHMNLKLTRSKLESLVGDLIKRTI 363
            :|..:||.||..||            |:.:|.        .|..:..::|::.|.|...|..:.|
  Rat   260 KLMNSAEVAKHSLS------------TLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCI 312

  Fly   364 QPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPS----RSVNPDEAVAVGAAVQ 424
            :..:..|..:..:..:|.:|:|.||.:|:|::|..:::||   |:    .|:.|||.:.:|||::
  Rat   313 EAVRALLQQSGFTADDINKVVLCGGSSRIPRLQQLIKDLF---PAGDLLNSIPPDEVIPIGAAIE 374

  Fly   425 GGVLAGDVT----DVLLLDVTP---LSLGIETLG-GVFTRLISRNTTIPTKKSQVF-STASDGQT 480
            .|:|.|..:    |.:|::.:.   |..|::..| ..||.|....|.:|.::.... :..|....
  Rat   375 AGILVGKESTSGDDSVLIECSARDILVKGVDESGANRFTVLFPSGTPLPARRQHTLQAPGSISSV 439

  Fly   481 QVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQI 545
            .:|:...:|:..:..:.| .....|..:.....|:..|..|..:..:|.:.|:..|:.|||.:.|
  Rat   440 CLELYESEGKNSVKEETK-FAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQETGKCEAI 503

  Fly   546 VIQ 548
            .::
  Rat   504 TVE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	156/523 (30%)
		HSPA9-like_NBD	51..428	CDD:212683	129/392 (33%)
		Syntaphilin	<566..>642	CDD:291936
Hspa14	NP_001004257.1	HSPA14-like_NBD	2..376	CDD:212680	128/390 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900