Protein Alignment Hsc70-5 and hsp70.3

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_571472.2
• Gene: hsp70.3 / 30671
• ZFINID: ZDB-GENE-110713-1
• Length: 643
• Species: Danio rerio
• Alignment Length: 646
• Identity: 324/646 - (50%)
• Similarity: 430/646 - (66%)
• Gaps: 26/646 - (4%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            ||..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Zfish     5 KGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPNNT 68

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGD----AWVSSTDGKVYSPSQIGAFILMKMKE 176
            .:..|||||||||||.|:.|:.:.|:|||  |:|.    |.....:.|.::|.:|.:.:|:||||
Zfish    69 VFDAKRLIGRRFDDPVVQSDMKHWSFKVV--SDGGKPKVAVEHKGENKTFNPEEISSMVLVKMKE 131

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMD--KTEDKI 239
            .|||||...|.|||:||||||||||||||||||.||||||||:||||||||:|||:|  |:.::.
Zfish   132 IAEAYLGQKVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGKSSERN 196

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|:.|:||||:|.|||.||||||||.:||..|.|||:....||.::..|
Zfish   197 VLIFDLGGGTFDVSILTIEDGIFEVKATAGDTHLGGEDFDNRMVNHFVEEFKRKHKKDISQNKRA 261

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|:.|.:
Zfish   262 LRRLRTACERAKRTLSSSSQASIEIDSLYEGID------FYTSITRARFEELCSDLFRGTLDPVE 320

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |||.||::.|::|.:::||||.||:||:|..:|:.| ||:.::|:|||||||.|||||..:|.||
Zfish   321 KALRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGRELNKSINPDEAVAYGAAVQAAILMGD 385

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.||||||||.|||.|.||.||||||||::|.|:|.||.|..|.|:|.:|||.
Zfish   386 TSGNVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYSDNQPGVLIQVFEGERA 450

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|||.||.|||:.:|.| ...|.|||:
Zfish   451 MTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAADKSTGKQNKITITNDKGRLSKE 515

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLR 619
            |||.|:::|::|...|..:||.|...|..||...:.:..:|:  .|.::..|:.:::.::..:..
Zfish   516 EIERMVQEADKYKAEDDLQREKISAKNSLESYAFNMKNSVEDDNLKGKISEEDKKRVIEKCNEAV 580

  Fly   620 TLLANKETADLEEVRKATSSLQQSSLKLFELAYK-KMSAERESNAGAGSSDSSSSSDTSGE 679
            :.|.|.:.||.||.......|::....:....|: .|.|........|:|.:|:...|..|
Zfish   581 SWLENNQLADKEEYEHQLKELEKVCNPVISKLYQGGMPAGGCGAQARGASGASAQGPTIEE 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	319/631 (51%)
		HSPA9-like_NBD	51..428	CDD:212683	205/385 (53%)
		Syntaphilin	<566..>642	CDD:291936	18/77 (23%)
hsp70.3	NP_571472.2	PTZ00009	5..643	CDD:240227	324/646 (50%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	203/383 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820