DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and Hsph1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	211/785 - (26%)
Similarity:	336/785 - (42%)	Gaps:	182/785 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            :|:|:|:|:.:..:||......:.|.|....|.|||.::|... .|.:|:.||.|.:|::.||..
  Rat     2 SVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPK-NRTIGVAAKNQQITHANNTVS 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAE 179
            :.||..||.|:||.::|:..||||.:|...||...:.   ..:..::|..||.|.:|.|:|||||
  Rat    66 SFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAE 130

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-------D 237
            ..|..||.:.|::||::|.|::|::..||.||.|||.||::|:.||.||.||:.|.:       .
  Rat   131 NNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKP 195

  Fly   238 KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDN 302
            :::...|:|..:|.:|.....||..:|..|..|..|||::||..:|....||||....:|.:...
  Rat   196 RVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKI 260

  Fly   303 IAMQRLKEAAEKAKCELSSSQQTD--INLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQP 365
            .|:.||.:..||.| :|.||..||  :|:.....|    :.::.|:.||:.|.|..:|:::...|
  Rat   261 RALLRLHQECEKLK-KLMSSNSTDLPLNIECFMND----KDVSAKMNRSQFEELCAELLQKIEVP 320

  Fly   366 CQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL-- 428
            ....:....:...|:..:.:|||.||:|.|:..:...||:..|.::|.|||||.|.|:|..:|
  Rat   321 LHLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSP 385

  Fly   429 AGDVTDVLLLDVTPLSLGI------ETLGGVFTRLISRNTTIPTKKSQVF--------------- 472
            |..|.:..:.|..|..:.:      |...||. .:.|||...|..|...|
  Rat   386 AFKVREFSVTDAVPFPISLVWNHDSEETEGVH-EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDP 449

  Fly   473 ------------------STASDGQ-TQVEIKVHQGEREMANDNKLLGSFTL------VGIPPAP 512
                              |...||: ::|::||.....         |.||:      ..:|...
  Rat   450 QAVPYPEAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTH---------GIFTISTASMVEKVPTEE 505

  Fly   513 RGVPQIEVVF-----------DIDANGIVHVSAKDKGTGKEQQIVI---QSSGGLSKDEI---EN 560
            .....:|...           |:|.|    :...:...|.:.|:..   |:|......|:   ||
  Rat   506 EDGSSVEADMECPNQKPAESSDVDKN----IQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEEN 566

  Fly   561 MI--------KKAEEYATADKQK-------------------RELIE--IVNQGESIVHD----- 591
            .|        ||.::...|.|.|                   |:|:.  |..:|:.|:.|
  Rat   567 KIPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKE 631

  Fly   592 -------TETKMEEFKSQL--PAEE--CEKLKKEIADLRTLLANKETAD---------------- 629
                   .|..:.||:.:|  |.|:  ||:..::...|.|     ||.|
  Rat   632 RNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLT-----ETEDWLYEEGEDQAKQAYID 691

  Fly   630 -LEEVRKATSSL-------QQSSLKLFELA-----YKKMSAERESNAGAGSSDSSSSSDTSGEAK 681
             |||:.|..:.:       ::....|.||.     |.|::|:..     |..:..:..|.| |.|
  Rat   692 KLEELMKMGTPVKVRFQEAEERPRVLEELGQRLQHYAKIAADFR-----GKDEKYNHIDES-EMK 750

  Fly   682 KEEKN 686
            |.||:
  Rat   751 KVEKS 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	203/763 (27%)
		HSPA9-like_NBD	51..428	CDD:212683	133/386 (34%)
		Syntaphilin	<566..>642	CDD:291936	26/136 (19%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	133/387 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900