Protein Alignment Hsc70-5 and HSPA12A

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 160/725 - (22%)
• Similarity: 258/725 - (35%)
• Gaps: 236/725 - (32%)

  Fly    12 ARQAG------VVPSHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLAVME 70
            ||..|      :.|||:         :....:.:|.|..:.      .|:.:|.|||:|..|...
Human    42 ARSLGDTGITPLSPSHI---------VNDTDSNVSEQQSFL------VVVAVDFGTTSSGYAYSF 91

  Fly    71 GKQAK---VIENAEGA------RTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRR 126
            .|:.:   |:...||.      :.||:.:..|.:        .|..:...:|..||       ..
Human    92 TKEPECIHVMRRWEGGDPGVSNQKTPTTILLTPE--------RKFHSFGYAARDFY-------HD 141

  Fly   127 FDDPEVKKDITNLSYKVVKASNGDAW----VSSTDGKVYSPSQIGAFILMKMKETA--------- 178
            .|..|.|:.:....:|:...:.||..    :::.:||.....:|.|:.|...||.|
Human   142 LDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKALEIFAYALQYFKEQALKELSDQAG 206

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL------NVLRVINEPTAAAL--------- 228
            ..:.|:.|: .|:||||.:....:|..:.|...|||      ..|.:..||.||::
Human   207 SEFENSDVR-WVITVPAIWKQPAKQFMRQAAYQAGLASPENSEQLIIALEPEAASIYCRKLRLHQ 270

  Fly   229 -----------------AYGMDKTE------------------------------DKIIAVYDLG 246
                             ..|...|:                              ||.:.| |.|
Human   271 MIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTFLVENVIGEIWSELEEGDKYVVV-DSG 334

  Fly   247 GGTFDISILEIQ------KGVFEVKSTNG-----------DTLL---GGEDFDNHIVNFLVAEFK 291
            |||.|:::.:|:      |.::  |:|.|           :.||   .||||        :.:||
Human   335 GGTVDLTVHQIRLPEGHLKELY--KATGGPYGSLGVDYEFEKLLYKIFGEDF--------IEQFK 389

  Fly   292 ---KDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMD------AAGPQHMNLKLT 347
               ..:.:|:.   ||.:..|.||...:     :...:|.||:..:|      ....:|   .|.
Human   390 IKRPAAWVDLM---IAFESRKRAAAPDR-----TNPLNITLPFSFIDYYKKFRGHSVEH---ALR 443

  Fly   348 RSKLE--------------SLVGDLIKRTIQPCQKALSDAEVSKSEIGEV---LLVGGMTRMPKV 395
            :|.::              ..:..|.|.||....:.|.|. ..|.|:..|   .||||....|.:
Human   444 KSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDL-FQKPEVSTVKFLFLVGGFAEAPLL 507

  Fly   396 QSTVQELFGRQPSRSVNPDEAVAVGAAV-QGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLIS 459
            |..||..||.| .|.:.|.:   ||..: :|.||.|....|:.:..:||:.|:    ||..|.:.
Human   508 QQAVQAAFGDQ-CRIIIPQD---VGLTILKGAVLFGLDPAVIKVRRSPLTYGV----GVLNRYVE 564

  Fly   460 RNTTIPTKKSQVFSTASDGQ---TQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVV 521
            ...  |.:|..|    .||.   |.|..|....::.:|....:..|:|    |..|   .|:.:|
Human   565 GKH--PPEKLLV----KDGTRWCTDVFDKFISADQSVALGELVKRSYT----PAKP---SQLVIV 616

  Fly   522 FDIDANGIVHVS-AKDKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQG 585
            .:|.::...:|| ..|.|..|...:.:..:|               ...||...:||:..::..|
Human   617 INIYSSEHDNVSFITDPGVKKCGTLRLDLTG---------------TSGTAVPARREIQTLMQFG 666

  Fly   586 ESIVHDTETK 595
                 |||.|
Human   667 -----DTEIK 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	152/680 (22%)
		HSPA9-like_NBD	51..428	CDD:212683	111/507 (22%)
		Syntaphilin	<566..>642	CDD:291936	9/30 (30%)
HSPA12A	NP_001317093.1	HSPA12A_like_NBD	74..540	CDD:212685	113/508 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900